Heilig, Markus

A key role for corticotropin-releasing factor in alcohol dependence

Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 503

1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial

Kakko, J., Svanborg, K. D., Kreek, M. J., & Heilig, M. (2003) · The Lancet

Opioid Use Disorder TreatmentSubstance Abuse Treatment and Outcomes

Cited by 466

REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

Heilig, M., Egli, M., Crabbe, J. C., & Becker, H. C. (2010) · Addiction Biology

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 435

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats

Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 319

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

Sommer, W. H., Rimondini, R., Hansson, A. C., Hipskind, P. A., Gehlert, D. R., Barr, C. S., & Heilig, M. A. (2008) · Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 309

Time to connect: bringing social context into addiction neuroscience

Heilig, M., Epstein, D. H., Nader, M. A., & Shaham, Y. (2016) · Nature Reviews Neuroscience

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 298

A molecular mechanism for choosing alcohol over an alternative reward

Augier, E., Barbier, E., Dulman, R. S., Licheri, V., Augier, G., Domi, E., Barchiesi, R., Farris, S., Nätt, D., Mayfield, R. D., et al. (2018) · Science

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 241

Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions

Möller, C., Wiklund, L., Sommer, W., Thorsell, A., & Heilig, M. (1997) · Brain Research

Neurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Cited by 229

Improving translation of animal models of addiction and relapse by reverse translation

Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 212

Variation at the mu-opioid receptor gene ( OPRM1 ) influences attachment behavior in infant primates

Barr, C. S., Schwandt, M. L., Lindell, S. G., Higley, J. D., Maestripieri, D., Goldman, D., Suomi, S. J., & Heilig, M. (2008) · Proceedings of the National Academy of Sciences

Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

Cited by 191

Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism

Heilig, M., Zachrisson, O., Thorsell, A., Ehnvall, A., Mottagui-Tabar, S., Sjögren, M., Åsberg, M., Ekman, R., Wahlestedt, C., & Ågren, H. (2004) · Journal of Psychiatric Research

Neuropeptides and Animal PhysiologyStress Responses and Cortisol

Cited by 177

Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia

Karlsson, R.-M., Tanaka, K., Saksida, L. M., Bussey, T. J., Heilig, M., & Holmes, A. (2009) · Neuropsychopharmacology

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 165

The CRF1 antagonist verucerfont in anxious alcohol-dependent women: translation of neuroendocrine, but not of anti-craving effects

Schwandt, M. L., Cortes, C. R., Kwako, L. E., George, D. T., Momenan, R., Sinha, R., Grigoriadis, D. E., Pich, E. M., Leggio, L., & Heilig, M. (2016) · Neuropsychopharmacology

Substance Abuse Treatment and OutcomesStress Responses and Cortisol

Cited by 159

The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence

Suchankova, P., Yan, J., Schwandt, M. L., Stangl, B. L., Caparelli, E. C., Momenan, R., Jerlhag, E., Engel, J. A., Hodgkinson, C. A., Egli, M., et al. (2015) · Translational Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 146

Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-Dependent Individuals: A Randomized Controlled Experimental Medicine Study

Umhau, J. C., Momenan, R., Schwandt, M. L., Singley, E., Lifshitz, M., Doty, L., Adams, L. J., Vengeliene, V., Spanagel, R., Zhang, Y., et al. (2010) · Archives of General Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 144

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: Preclinical safety experiments and a phase 1b human laboratory study

Lee, M. R., Tapocik, J. D., Ghareeb, M., Schwandt, M. L., Dias, A. A., Le, A. N., Cobbina, E., Farinelli, L. A., Bouhlal, S., Farokhnia, M., et al. (2020) · Molecular Psychiatry

Regulation of Appetite and ObesityAlcohol Consumption and Health Effects

Cited by 129

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat

Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., et al. (2008) · Biological Psychiatry

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 120

Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S. (2010) · Neuroscience & Biobehavioral Reviews

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 117

Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients

Huang, M., Schwandt, M. L., Ramchandani, V. A., George, D. T., & Heilig, M. (2012) · Alcoholism: Clinical and Experimental Research

Child Abuse and TraumaPosttraumatic Stress Disorder Research

Cited by 116

Repetitive Transcranial Magnetic Stimulation in Alcohol Dependence: A Randomized, Double-Blind, Sham-Controlled Proof-of-Concept Trial Targeting the Medial Prefrontal and Anterior Cingulate Cortices

Harel, M., Perini, I., Kämpe, R., Alyagon, U., Shalev, H., Besser, I., Sommer, W. H., Heilig, M., & Zangen, A. (2022) · Biological Psychiatry

Transcranial Magnetic Stimulation StudiesSubstance Abuse Treatment and Outcomes

Cited by 115

Association of a Functional Polymorphism in the μ-Opioid Receptor Gene With Alcohol Response and Consumption in Male Rhesus Macaques

Barr, C. S., Schwandt, M., Lindell, S. G., Chen, S. A., Goldman, D., Suomi, S. J., Higley, J. D., & Heilig, M. (2007) · Archives of General Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 105

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model

Skinbjerg, M., Liow, J.-S., Seneca, N., Hong, J., Lu, S., Thorsell, A., Heilig, M., Pike, V. W., Halldin, C., Sibley, D. R., et al. (2010) · NeuroImage

Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Cited by 86

Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats

Cippitelli, A., Damadzic, R., Singley, E., Thorsell, A., Ciccocioppo, R., Eskay, R. L., & Heilig, M. (2012) · Pharmacology Biochemistry and Behavior

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 84

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats

Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

Cited by 79