Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients
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Background: This study examined the prevalence of single‐ and multiple‐type childhood trauma exposure (CTE) among alcoholic patients undergoing inpatient detoxification and treatment. The relationships between various types of CTE and lifetime psychiatric comorbidities and suicide attempts were also explored. Methods: A total of 196 alcoholic inpatients were assessed by Structured Clinical Interview for DSM‐IV Axis I Disorders and C hildhood T rauma Q uestionnaire (CTQ) for CTE history. Results: The overall prevalence of CTE in the entire sample was high (55.1%). Specifically, the prevalence of emotional abuse was 21.4%, physical abuse 31.1%, sexual abuse 24.0%, emotional neglect 20.4%, and physical neglect 19.9%. Regarding multiple types of CTE, 31.7 and 18.9% reported at least 2 and at least 3 CTE types, respectively. Strikingly, among those with at least 1 positive CTQ category, more than half reported 2 or more CTE types. A history of emotional abuse increased the risk of mood disorder, in particular major depressive disorder, as well as posttraumatic stress disorder (PTSD). Physical abuse contributed to the prediction of suicide attempts, while sexual abuse was associated with a diagnosis of anxiety disorder, PTSD, and multiple comobidities (e.g., anxiety and mood disorder). The number of reported CTE types or the total score of the CTQ predicted an increased risk of having single or multiple psychiatric comorbidities as well as suicide attempts. Conclusions: We observed high rates of a broad range of CTE types and a trend for CTE‐specific enhancement of risk for various psychiatric outcomes among alcoholic inpatients. Of note, a dose–response relationship between number of CTE types and risk of psychiatric comorbidities as well as suicide attempts was found. We suggest a wide range of CTE should be included when exploring the effects of CTE or developing prevention and treatment strategies among alcoholic subjects.
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The severity of physical and psychological consequences may be associated with the number of experienced ELS/CT events.
“The severity of physical and psychological consequences may be also associated with the number of experienced ELS/CT events (13, 17, 43, 44).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [43]
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- Authors
- Huang, M., Schwandt, M. L., Ramchandani, V. A., George, D. T., & Heilig, M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Heilig, Markus
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2012-03-15
- Volume
- 36
- Issue
- 6
- Pages
- 1099-1107
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC3370064
- OpenAlex
- W2095589920
- Semantic Scholar
- 5ab034337a4b077c638636e474611c83f7778ef9
- Cited by
- 116
- References
- 51
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 2
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (ZIAAA000487)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Safety Research › Child Welfare and Adoption
- Keywords
- childhood trauma, psychiatric comorbidity, alcoholism, inpatient detoxification, suicide attempts, emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, major depressive disorder, post-traumatic stress disorder, anxiety disorders, mood disorders, dose-response relationship
- MeSH terms
- Adult, Alcoholism, Anxiety Disorders, Mental Disorders, Major Depressive Disorder, Female, Humans, Inpatients, Male, Middle Aged, Stress Disorders, Post-Traumatic, Suicide, Attempted, Comorbidity, Adult Survivors of Child Abuse
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