Lotze, Michael T.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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The Beclin 1 network regulates autophagy and apoptosis

Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 2,485

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

Rosenberg, S. A., Packard, B. S., Aebersold, P. M., Solomon, D., Topalian, S. L., Toy, S. T., Simon, P., Lotze, M. T., Yang, J. C., Seipp, C. A., et al. (1988) · New England Journal of Medicine

Immunotherapy and Immune ResponsesCutaneous Melanoma Detection and Management

Cited by 2,389

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy

Ferroptosis and cancer prognosisAutophagy in Disease and Therapy

Cited by 2,332

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine

Advanced Glycation End Products researchOrgan Transplantation Techniques and Outcomes

Cited by 1,113

HMGB1 in health and disease

Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 956

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports

Ferroptosis and cancer prognosisCancer-related Molecular Pathways

Cited by 952

Endogenous HMGB1 regulates autophagy

Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology

Autophagy in Disease and TherapyAdvanced Glycation End Products research

Cited by 951

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

Rubartelli, A., & Lotze, M. T. (2007) · Trends in Immunology

Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 614

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

Zhu, S., Zhang, Q., Sun, X., Zeh, H. J., Lotze, M. T., Kang, R., & Tang, D. (2017) · Cancer Research

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 576

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

Tang, D., Kang, R., Cheh, C.-W., Livesey, K. M., Liang, X., Schapiro, N. E., Benschop, R., Sparvero, L. J., Amoscato, A. A., Tracey, K. J., et al. (2010) · Oncogene

Advanced Glycation End Products researchCell death mechanisms and regulation

Cited by 461

Masquerader: High Mobility Group Box-1 and Cancer

Ellerman, J. E., Brown, C. K., de Vera, M., Zeh, H. J., Billiar, T., Rubartelli, A., & Lotze, M. T. (2007) · Clinical Cancer Research

Advanced Glycation End Products researchS100 Proteins and Annexins

Cited by 355

Programmed Necrosis Induced by Asbestos in Human Mesothelial Cells Causes High-Mobility Group Box 1 Protein Release and Resultant Inflammation

Yang, H., Rivera, Z., Jube, S., Nasu, M., Bertino, P., Goparaju, C., Franzoso, G., Lotze, M. T., Krausz, T., Pass, H. I., et al. (2010) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesCell death mechanisms and regulation

Cited by 281

Safety and biologic response of pre-operative autophagy inhibition in combination with gemcitabine in patients with pancreatic adenocarcinoma

Boone, B. A., Bahary, N., Zureikat, A. H., Moser, A. J., Normolle, D. P., Wu, W.-C., Singhi, A. D., Bao, P., Bartlett, D. L., Liotta, L. A., et al. (2015) · Annals of Surgical Oncology

Pancreatic and Hepatic Oncology ResearchAutophagy in Disease and Therapy

Cited by 234

A randomized Phase II preoperative study of autophagy inhibition with high-dose hydroxychloroquine and gemcitabine/nab-paclitaxel in pancreatic cancer patients

Zeh, H. J., Bahary, N., Boone, B. A., Singhi, A. D., Miller-Ocuin, J. L., Normolle, D. P., Zureikat, A. H., Hogg, M. E., Bartlett, D. L., Lee, K. K., et al. (2020) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchAutophagy in Disease and Therapy

Cited by 233

The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia

Kang, R., Loux, T., Tang, D., Schapiro, N. E., Vernon, P., Livesey, K. M., Krasinskas, A., Lotze, M. T., & Zeh, H. J. (2012) · Proceedings of the National Academy of Sciences

Advanced Glycation End Products researchPancreatic and Hepatic Oncology Research

Cited by 163

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’

Huang, J., Xie, Y., Sun, X., Zeh, H. J., Kang, R., Lotze, M. T., & Tang, D. (2015) · Ageing Research Reviews

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 144

Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury

Izuishi, K., Tsung, A., Jeyabalan, G., Critchlow, N. D., Li, J., Tracey, K. J., Demarco, R. A., Lotze, M. T., Fink, M. P., Geller, D. A., et al. (2006) · The Journal of Immunology

Advanced Glycation End Products researchOrgan Transplantation Techniques and Outcomes

Cited by 116

Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression

Diniz, B. S., Sibille, E., Ding, Y., Tseng, G., Aizenstein, H. J., Lotrich, F., Becker, J. T., Lopez, O. L., Lotze, M. T., Klunk, W. E., et al. (2015) · Molecular Psychiatry

Dementia and Cognitive Impairment ResearchTreatment of Major Depression

Cited by 116

A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States

Tang, D., Billiar, T. R., & Lotze, M. T. (2012) · Molecular Medicine

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 112

Second‐generation tetracycline‐regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness

Agha‐Mohammadi, S., O'Malley, M., Etemad, A., Wang, Z., Xiao, X., & Lotze, M. T. (2004) · The Journal of Gene Medicine

Virus-based gene therapy researchBacterial Genetics and Biotechnology

Cited by 110

Effect of Chronic Treatment with the Glucocorticoid Antagonist RU 486 in Man: Toxicity, Immunological, and Hormonal Aspects

LAUE, L., LOTZE, M. T., CHROUSOS, G. P., BARNES, K., LORIAUX, D. L., & FLEISHER, T. A. (1990) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 77

SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma

Fei, N., Wen, S., Ramanathan, R., Hogg, M. E., Zureikat, A. H., Lotze, M. T., Bahary, N., Singhi, A. D., Zeh, H. J., & Boone, B. A. (2021) · Clinical and Translational Science

Pancreatic and Hepatic Oncology ResearchAutophagy in Disease and Therapy

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