The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Open accessAbstract
Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism. Here, we show that TP53 limits erastin-induced ferroptosis by blocking dipeptidyl-peptidase-4 (DPP4) activity in a transcription-independent manner. Loss of TP53 prevents nuclear accumulation of DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis. These findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.
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p53 appears to inhibit ferroptosis in colorectal cancer cells, at least in part by inhibiting DPP4 activity in a transcription-independent manner.
“p53 appears to inhibit ferroptosis in colorectal cancer cells, at least in part by inhibiting DPP4 activity in a transcription-independent manner [584].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [584]
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- Authors
- Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R., Kroemer, G., & Tang, D.
- Affiliations
- Central South University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- University of Pittsburgh (US)
- Jilin University (CN)
- Karolinska University Hospital (SE)
- Corresponding author
- Kroemer, Guido
- Tang, Daolin
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 20
- Issue
- 7
- Pages
- 1692-1704
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2745520112
- Cited by
- 952
- References
- 59
- Citations by year
- 2026: 74 · 2025: 119 · 2024: 130 · 2023: 159 · 2022: 181 · 2021: 141 · 2020: 65 · 2019: 47 · 2018: 30 · 2017: 5
- FWCI
- 33.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH (R01GM115366, R01CA160417, R01CA181450)
- Natural Science Foundation of Guangdong Province (2016A030308011)
- American Cancer Society (RSG-16-014-01-CDD)
- National Natural Science Foundation of China (31671435, 81400132, 8177100253)
- National Funds of Developing Local Colleges and Universities (B16056001)
- Department of Science and Technology of Guangdong Province (2016B030229008)
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
- University of Pittsburgh Cancer Institute (P30CA047904)
- Ligue contre le Cancer
- Agence National de la Recherche (ANR)
- E-Rare-2, the ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Cancéropôle Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Médicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumière
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- p53, ferroptosis, dipeptidyl peptidase IV, erastin, lipid peroxidation, nuclear accumulation, plasma membrane, lipid metabolism, colorectal cancer, precision medicine
- MeSH terms
- Vildagliptin, Adamantane, Animals, Antineoplastic Agents, Cell Membrane, Cell Nucleus, Humans, Injections, Subcutaneous, Iron, Mice, Nude, Nitriles, Piperazines, Pyrrolidines, Colorectal Neoplasms, Lipid Peroxidation, Signal Transduction, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Apoptosis, Dipeptidyl Peptidase 4, Caco-2 Cells, Xenograft Model Antitumor Assays, RNA, Small Interfering, HCT116 Cells, Cell Line, Tumor, Mice, Dipeptidyl-Peptidase IV Inhibitors
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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