Cited by 614Immune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced Glycation End Products research

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

Rubartelli, Anna, Lotze, Michael T.·2007·Trends in Immunology

Abstract

Immune responses are initiated and perpetuated by molecules derived from microorganisms pathogen-associated molecular-pattern molecules or from the damage or death of host cells [damage-associated molecular-pattern (DAMP) molecules]. Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that, when released outside the cell following tissue injury, move from a reducing to an oxidizing milieu resulting in their functional denaturation. Here, we discuss the consequences of DAMP oxidation on the outcome of acute inflammation. We also suggest that, outside the cell, DAMPs might adopt novel conformations or alter the redox of the extracellular environment to more closely mimic the internal one, thereby avoiding oxidation-mediated inactivation and promoting pathology. We propose that chronic inflammation associated with autoimmunity, chronic viral infection and cancer is probably mediated by persistent release and function of DAMPs, promoting and promoted by a disordered redox environment.

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Crossref · 10.1016/j.it.2007.08.004

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Authors
Rubartelli, A., & Lotze, M. T.
Affiliations
UPMC Hillman Cancer Center (US)
Corresponding author
Rubartelli, Anna
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2007-10
Volume
28
Issue
10
Pages
429-436
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2104414795
Cited by
614
References
67
Citations by year
2026: 8 · 2025: 18 · 2024: 26 · 2023: 25 · 2022: 28 · 2021: 32 · 2020: 35 · 2019: 38 · 2018: 33 · 2017: 43 · 2016: 19 · 2015: 54 · 2014: 42 · 2013: 50 · 2012: 39
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pennsylvania Department of Health
  • National Cancer Institute (P01CA101944)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords
damage-associated molecular patterns, redox conditions, acute inflammation, chronic inflammation, autoimmunity, chronic viral infection, cancer, protein denaturation, tissue damage, innate immunity
MeSH terms
Humans, Immunity, Innate, Inflammation, Neoplasms, Oxidation-Reduction, Proteins, Cytokines, Inflammation Mediators

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