Opal, Steven M.

The third international consensus definitions for sepsis and septic shock (Sepsis-3).

Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 28,250

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock

Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine

Sepsis Diagnosis and TreatmentAntibiotics Pharmacokinetics and Efficacy

Cited by 9,694

Anti-Inflammatory Cytokines

Opal, S. M., & DePalo, V. A. (2000) · Chest

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 1,752

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Seymour, C. W., Kennedy, J. N., Wang, S., Chang, C.-C. H., Elliott, C. F., Xu, Z., Berry, S., Clermont, G., Cooper, G., Gomez, H., et al. (2019) · JAMA

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 1,567

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial*

Shakoory, B., Carcillo, J. A., Chatham, W. W., Amdur, R. L., Zhao, H., Dinarello, C. A., Cron, R. Q., & Opal, S. M. (2016) · Critical Care Medicine

Sepsis Diagnosis and TreatmentAutoimmune and Inflammatory Disorders Research

Cited by 867

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial

Opal, S. M., Laterre, P.-F., Francois, B., LaRosa, S. P., Angus, D. C., Mira, J.-P., Wittebole, X., Dugernier, T., Perrotin, D., Tidswell, M., et al. (2013) · JAMA

Sepsis Diagnosis and TreatmentImmune Response and Inflammation

Cited by 812

Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

Opal, S. M., Scannon, P. J., Vincent, J., White, M., Carroll, S. F., Palardy, J. E., Parejo, N. A., Pribble, J. P., & Lemke, J. H. (1999) · The Journal of Infectious Diseases

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 609

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial

Laterre, P.-F., Berry, S. M., Blemings, A., Carlsen, J. E., François, B., Graves, T., Jacobsen, K., Lewis, R. J., Opal, S. M., Perner, A., et al. (2019) · JAMA

Sepsis Diagnosis and TreatmentHemodynamic Monitoring and Therapy

Cited by 147

Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases

Rello, J., van Engelen, T. S. R., Alp, E., Calandra, T., Cattoir, V., Kern, W. V., Netea, M. G., Nseir, S., Opal, S. M., van de Veerdonk, F. L., et al. (2018) · Clinical Microbiology and Infection

Sepsis Diagnosis and TreatmentBacterial Identification and Susceptibility Testing

Cited by 143

Interleukin-10 potential benefits and possible risks in clinical infectious diseases

Opal, S. M., Wherry, J. C., & Grint, P. (1998) · Clinical Infectious Diseases

Cytokine Signaling Pathways and InteractionsImmune Response and Inflammation

Cited by 114

Clinical Characteristics, Management Strategies, and Cost Implications of a Statewide Outbreak of Enterovirus Meningitis

Rice, S. K., Heinl, R. E., Thornton, L. L., & Opal, S. M. (1995) · Clinical Infectious Diseases

Viral Infections and Immunology ResearchInfectious Encephalopathies and Encephalitis

Cited by 72