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Cited by 114Cytokine Signaling Pathways and InteractionsImmune Response and InflammationRheumatoid Arthritis Research and Therapies

Interleukin-10 potential benefits and possible risks in clinical infectious diseases

Opal, Steven M., Wherry, Janice C., Grint, Paul·1998·Clinical Infectious Diseases
DOI 10.1086/515032
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Abstract

Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2-type cytokine that upregulates humoral immune responses and attenuates cell-mediated immune reactions. This cytokine has a number of immunomodulatory properties that might be clinically useful in a variety of inflammatory and infectious disease states. Clinical trials with human recombinant IL-10 are already in progress. Carefully selected patients with inflammatory conditions may benefit from IL- 10 therapy if concomitant infectious diseases are recognized and treated appropriately.

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Authors
Opal, S. M., Wherry, J. C., & Grint, P.
Affiliations
  • Brown University (US)
  • Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author
Opal, Steven M.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1998-12-01
Volume
27
Issue
6
Pages
1497-1507
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/515032
OpenAlex
W1985344660
Cited by
114
References
94
Citations by year
2025: 2 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
IL-10, anti-inflammatory cytokines, immunomodulation, inflammatory cytokines, Th2 cytokines, humoral immune response, cell-mediated immunity, inflammatory diseases, infectious diseases, clinical trials
MeSH terms
Adjuvants, Immunologic, Animals, Anti-Inflammatory Agents, Non-Steroidal, Communicable Diseases, Humans, Interleukin-10, Receptors, Interleukin, Endotoxemia, Mice, Receptors, Interleukin-10

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