Cited by 609Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

Opal, Steven M., Scannon, Patrick J., Vincent, Jean‐Louis, White, Mark, Carroll, Stephen F., Palardy, John E., Parejo, Nicolas A., Pribble, John P. +1 more·1999·The Journal of Infectious Diseases

Abstract

Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. Endotoxin levels were significantly greater than control levels (n=33; mean +/- SD, 5.1+/-7.3 pg/mL) in 78.3% of patients. Median endotoxin levels in patients with sepsis were 300 pg/mL (25%-75% interquartile range, 110-726 pg/mL). LBP levels were elevated in 97% of patients compared with normal control values of 4.1+/-1.65 microgram/mL. Median LBP levels in patients with sepsis were 31.2 microgram/mL (interquartile range, 22.5-47.7 microgram/mL). Median endotoxin levels at study entry were more highly elevated (515 vs. 230 pg/mL; P<.01), and LBP levels were less highly elevated (28.0 vs. 33.2 microgram/mL; P<.05) in nonsurvivors than survivors over the 28-day study period. No correlation was found between endotoxin and LBP levels. The quantitative level of both endotoxin and LBP may have prognostic significance in patients with severe sepsis.

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Crossref · 10.1086/315093

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  • In sepsis, blood endotoxin levels can be very high, up to 500 pg/ml.

    “blood endotoxin levels can be very high (up to 500 pg/ml [13])”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [13]

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Authors
Opal, S. M., Scannon, P. J., Vincent, J., White, M., Carroll, S. F., Palardy, J. E., Parejo, N. A., Pribble, J. P., & Lemke, J. H.
Affiliations
  • Brown University (US)
  • XOMA (United States) (US)
  • Université Libre de Bruxelles (BE)
  • University of Iowa (US)
Corresponding author
Opal, Steven M.
Venue
The Journal of Infectious Diseases
Published
1999-11
Volume
180
Issue
5
Pages
1584-1589
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2147383865
Cited by
609
References
39
Citations by year
2026: 12 · 2025: 26 · 2024: 26 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 35 · 2019: 33 · 2018: 12 · 2017: 26 · 2016: 30 · 2015: 32 · 2014: 17 · 2013: 34 · 2012: 21
FWCI
9.60
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
lipopolysaccharide, lipopolysaccharide-binding protein, endotoxin, severe sepsis, septic shock, prognostic factors, mortality prediction, plasma endotoxin levels
MeSH terms
Lipopolysaccharide-Binding Protein, Acute-Phase Proteins, Adult, Aged, Carrier Proteins, Endotoxins, Female, Humans, Lipopolysaccharides, Male, Membrane Glycoproteins, Middle Aged, Prognosis, Shock, Septic, Fungemia, Bacteremia

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