Sirlin, Claude B.

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

Loomba, R., Seguritan, V., Li, W., Long, T., Klitgord, N., Bhatt, A., Dulai, P. S., Caussy, C., Bettencourt, R., Highlander, S. K., et al. (2017) · Cell Metabolism

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 1,123

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 771

Decoding global gene expression programs in liver cancer by noninvasive imaging

Segal, E., Sirlin, C. B., Ooi, C., Adler, A. S., Gollub, J., Chen, X., Chan, B. K., Matcuk, G. R., Barry, C. T., Chang, H. Y., et al. (2007) · Nature Biotechnology

Radiomics and Machine Learning in Medical ImagingMedical Imaging Techniques and Applications

Cited by 629

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials: Hepatology

Noureddin, M., Lam, J., Peterson, M. R., Middleton, M., Hamilton, G., Le, T.-A., Bettencourt, R., Changchien, C., Brenner, D. A., Sirlin, C., et al. (2013) · Hepatology

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 550

A Gut Microbiome Signature for Cirrhosis Due to Nonalcoholic Fatty Liver Disease

Caussy, C., Tripathi, A., Humphrey, G., Bassirian, S., Singh, S., Faulkner, C., Bettencourt, R., Rizo, E., Richards, L., Xu, Z. Z., et al. (2019) · Nature Communications

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 338

A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes

Ajmera, V., Cepin, S., Tesfai, K., Hofflich, H., Cadman, K., Lopez, S., Madamba, E., Bettencourt, R., Richards, L., Behling, C., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 327

Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

Schwimmer, J. B., Johnson, J. S., Angeles, J. E., Behling, C., Belt, P. H., Borecki, I., Bross, C., Durelle, J., Goyal, N. P., Hamilton, G., et al. (2019) · Gastroenterology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 298

Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis

Stine, J. G., Munaganuru, N., Barnard, A., Wang, J. L., Kaulback, K., Argo, C. K., Singh, S., Fowler, K. J., Sirlin, C. B., & Loomba, R. (2021) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 283

Diagnostic accuracy of noninvasive fibrosis models to detect change in fibrosis stage

Siddiqui, M. S., Yamada, G., Vuppalanchi, R., Van Natta, M., Loomba, R., Guy, C., Brandman, D., Tonascia, J., Chalasani, N., Neuschwander-Tetri, B., et al. (2019) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 272

Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

Lawitz, E. J., Coste, A., Poordad, F., Alkhouri, N., Loo, N., McColgan, B. J., Tarrant, J. M., Nguyen, T., Han, L., Chung, C., et al. (2018) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection

Cited by 217

Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: analysis of data from a phase II trial of selonsertib

Jayakumar, S., Middleton, M. S., Lawitz, E. J., Mantry, P. S., Caldwell, S. H., Arnold, H., Mae Diehl, A., Ghalib, R., Elkhashab, M., Abdelmalek, M. F., et al. (2019) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentUltrasound Imaging and Elastography

Cited by 208

Link between gut‐microbiome derived metabolite and shared gene‐effects with hepatic steatosis and fibrosis in NAFLD

Caussy, C., Hsu, C., Lo, M., Liu, A., Bettencourt, R., Ajmera, V. H., Bassirian, S., Hooker, J., Sy, E., Richards, L., et al. (2018) · Hepatology

Liver Disease Diagnosis and TreatmentGut microbiota and health

Cited by 205

Fibrosis progression rate in biopsy-proven nonalcoholic fatty liver disease among people with diabetes versus people without diabetes: a multicenter study

Huang, D. Q., Wilson, L. A., Behling, C., Kleiner, D. E., Kowdley, K. V., Dasarathy, S., Amangurbanova, M., Terrault, N. A., Diehl, A. M., Chalasani, N., et al. (2023) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 190

Effect of Weight Loss on Magnetic Resonance Imaging Estimation of Liver Fat and Volume in Patients With Nonalcoholic Steatohepatitis

Patel, N. S., Doycheva, I., Peterson, M. R., Hooker, J., Kisselva, T., Schnabl, B., Seki, E., Sirlin, C. B., & Loomba, R. (2015) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 173

Radiogenomic Analysis to Identify Imaging Phenotypes Associated with Drug Response Gene Expression Programs in Hepatocellular Carcinoma

Kuo, M. D., Gollub, J., Sirlin, C. B., Ooi, C., & Chen, X. (2007) · Journal of Vascular and Interventional Radiology

Radiomics and Machine Learning in Medical ImagingHepatocellular Carcinoma Treatment and Prognosis

Cited by 168

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Iwaisako, K., Haimerl, M., Paik, Y.-H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R. T., Downes, M., Evans, R. M., et al. (2012) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 157

Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease

Tamaki, N., Munaganuru, N., Jung, J., Yonan, A. Q., Loomba, R. R., Bettencourt, R., Ajmera, V., Valasek, M. A., Behling, C., Sirlin, C. B., et al. (2022) · Gut

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 130

Non-Invasive Biomarkers of Nonalcoholic Steatohepatitis: the FNIH NIMBLE project

Sanyal, A. J., Shankar, S. S., Calle, R. A., Samir, A. E., Sirlin, C. B., Sherlock, S. P., Loomba, R., Fowler, K. J., Dehn, C. A., Heymann, H., et al. (2022) · Nature Medicine

Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Cited by 56

Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis

Qadri, S., Vartiainen, E., Lahelma, M., Porthan, K., Tang, A., Idilman, I. S., Runge, J. H., Juuti, A., Penttilä, A. K., Dabek, J., et al. (2024) · JHEP Reports

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 55

MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH

Loomba, R., Amangurbanova, M., Bettencourt, R., Madamba, E., Siddiqi, H., Richards, L., Behling, C., Sirlin, C. B., Gottwald, M. D., Feng, S., et al. (2024) · Gut

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 43

Impact of Reference Standard on CT, MRI, and Contrast-enhanced US LI-RADS Diagnosis of Hepatocellular Carcinoma: A Meta-Analysis

van der Pol, C. B., McInnes, M. D. F., Salameh, J.-P., Chernyak, V., Tang, A., Bashir, M. R., for the LI-RADS IPD Group, Allen, B. C., Burke, L. M. B., Choi, J.-Y., et al. (2022) · Radiology

Hepatocellular Carcinoma Treatment and PrognosisRadiomics and Machine Learning in Medical Imaging

Cited by 38

Monitoring Fatty Liver Disease with MRI Following Bariatric Surgery: A Prospective, Dual-Center Study

Pooler, B. D., Wiens, C. N., McMillan, A., Artz, N. S., Schlein, A., Covarrubias, Y., Hooker, J., Schwimmer, J. B., Funk, L. M., Campos, G. M., et al. (2019) · Radiology

Bariatric Surgery and OutcomesLiver Disease Diagnosis and Treatment

Cited by 37