Bu, Guojun

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Chen, K., Martens, Y. A., Meneses, A., Ryu, D. H., Lu, W., Raulin, A. C., Li, F., Zhao, J., Chen, Y., Jin, Y., et al. (2022) · Molecular Neurodegeneration

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 115

Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer’s disease

Shinohara, M., Fujioka, S., Murray, M. E., Wojtas, A., Baker, M., Rovelet-Lecrux, A., Rademakers, R., Das, P., Parisi, J. E., Graff-Radford, N. R., et al. (2014) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 115

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch‐Daiello, J. L., Han, X., Fryer, J. D., et al. (2016) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 111

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C.-C., Atagi, Y., Chen, X.-F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S. S., Rosenberry, T. L., et al. (2016) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 110

APOE3 -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia

Liu, C.-C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A.-C., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 108

Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures

LaDu, M. J., Shah, J. A., Reardon, C. A., Getz, G. S., Bu, G., Hu, J., Guo, L., & Van Eldik, L. J. (2000) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 103

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Zhao, Y., Tseng, I.-C., Heyser, C. J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, P. E., et al. (2015) · Neuron

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 98

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development.

Narita, M., Bu, G., Holtzman, D. M., & Schwartz, A. L. (1997) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 96

TYROBP genetic variants in early-onset Alzheimer's disease

Pottier, C., Ravenscroft, T. A., Brown, P. H., Finch, N. A., Baker, M., Parsons, M., Asmann, Y. W., Ren, Y., Christopher, E., Levitch, D., et al. (2016) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 94

Prosaposin is a regulator of progranulin levels and oligomerization

Nicholson, A. M., Finch, N. A., Almeida, M., Perkerson, R. B., van Blitterswijk, M., Wojtas, A., Cenik, B., Rotondo, S., Inskeep, V., Almasy, L., et al. (2016) · Nature Communications

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 91

Lipoproteins in the Central Nervous System: From Biology to Pathobiology

Raulin, A.-C., Martens, Y. A., & Bu, G. (2022) · Annual Review of Biochemistry

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatments

Cited by 89

ApoE (Apolipoprotein E) in brain pericytes regulates endothelial function in an isoform-dependent manner by modulating basement membrane components

Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T., & Bu, G. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 89

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Chadarevian, J. P., Hasselmann, J., Lahian, A., Capocchi, J. K., Escobar, A., Lim, T. E., Le, L., Tu, C., Nguyen, J., Kiani Shabestari, S., et al. (2024) · Neuron

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 83

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Cook, C., Kang, S. S., Carlomagno, Y., Lin, W.-L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., et al. (2015) · Human Molecular Genetics

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 82

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease

Medway, C. W., Abdul-Hay, S., Mims, T., Ma, L., Bisceglio, G., Zou, F., Pankratz, S., Sando, S. B., Aasly, J. O., Barcikowska, M., et al. (2014) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 82

APOE2 is associated with longevity independent of Alzheimer’s disease

Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, G. W., et al. (2020) · eLife

Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

Cited by 82

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., et al. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 82

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

Wang, X., Huang, T., Zhao, Y., Zheng, Q., Thompson, R. C., Bu, G., Zhang, Y.-W., Hong, W., & Xu, H. (2014) · Cell Reports

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 77

ApoER2 is Endocytosed by a Clathrin‐Mediated Process Involving the Adaptor Protein Dab2 Independent of its Rafts' Association

Cuitino, L., Matute, R., Retamal, C., Bu, G., Inestrosa, N. C., & Marzolo, M. (2005) · Traffic

Cellular transport and secretionCaveolin-1 and cellular processes

Cited by 72

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling

Wang, W., Li, Y., Ma, F., Sheng, X., Chen, K., Zhuo, R., Wang, C., Zheng, H., Zhang, Y.-W., Bu, G., et al. (2023) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 71

Vascular ApoE4 impairs behavior by modulating gliovascular function

Yamazaki, Y., Liu, C.-C., Yamazaki, A., Shue, F., Martens, Y. A., Chen, Y., Qiao, W., Kurti, A., Oue, H., Ren, Y., et al. (2021) · Neuron

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 71

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

Fuentealba, R. A., Barría, M. I., Lee, J., Cam, J., Araya, C., Escudero, C. A., Inestrosa, N. C., Bronfman, F. C., Bu, G., & Marzolo, M.-P. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 70

Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y-dependent Sorting Motifs in Different Pathways

Donoso, M., Cancino, J., Lee, J., van Kerkhof, P., Retamal, C., Bu, G., Gonzalez, A., Cáceres, A., & Marzolo, M.-P. (2009) · Molecular Biology of the Cell

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 69

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

Jin, Y., Li, F., Sonoustoun, B., Kondru, N. C., Martens, Y. A., Qiao, W., Heckman, M. G., Ikezu, T. C., Li, Z., Burgess, J. D., et al. (2022) · Acta Neuropathologica

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 69