The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development.
Abstract
The epsilon 4 allele of apolipoprotein E (apoE) is an important risk factor for Alzheimer's disease. A major neuronal receptor for apoE within the brain is the low-density lipoprotein receptor-related protein (LRP). Using primary cultured hippocampal neurons, we examined the role of LRP in early neuronal development. LRP, as well as a 39-kDa protein that regulates its activity, is localized abundantly in developing neurons. Both the 39-kDa protein and an anti-LRP antibody inhibited neurite outgrowth of primary hippocampal neurons cultured in either serum-containing medium or on cortical astrocyte monolayers in serum-free medium. It is noteworthy that microtubule-associated protein-2 immunoreactive process outgrowth was decreased significantly in hippocampal neurons cultured on cortical astrocytes derived from apoE-deficient mice and was not diminished further following incubation with LRP inhibitors. Thus, these results suggest that LRP can influence aspects of neuronal process development and that apoE-containing lipoproteins may be one of the major LRP ligands that can contribute to this process.
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The stimulation of neurite outgrowth by apoE is, in part, mediated by LRP1.
“The stimulation of neurite outgrowth by apoE is, in part, mediated by LRP1 (Fagan et al., 1996; Holtzman et al., 1995; Narita et al., 1997; Nathan et al., 2002).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Narita et al., 1997
The stimulation of neurite outgrowth by apoE may be mediated by LRP1 or other apoE receptors.
“The stimulation of neurite outgrowth by apoE may be mediated by LRP1 (Fagan et al., 1996; Holtzman et al., 1995; Narita et al., 1997; Nathan et al., 2002) or other apoE receptors (DeMattos et al., 1998; Puttfarcken et al., 1997).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Narita et al., 1997
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- Authors
- Narita, M., Bu, G., Holtzman, D. M., & Schwartz, A. L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Narita, Masaaki
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1997-02
- Volume
- 68
- Issue
- 2
- Pages
- 587-595
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2031315682
- Cited by
- 96
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2021: 2 · 2020: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Institute on Aging (AG/NS13956)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- low density lipoprotein receptor-related protein, apolipoprotein E, APOE ε4, Alzheimer's disease, hippocampal neurons, neurite outgrowth, neuronal development, cortical astrocytes, MAP2, ApoE-deficient mice, lipoprotein receptors
- MeSH terms
- Animals, Antibodies, Apolipoproteins, Astrocytes, Blood Proteins, Carrier Proteins, Cell Division, Cells, Cultured, Fetus, Glycoproteins, Hippocampus, Ligands, Mice, Inbred C57BL, Mice, Mutant Strains, Neurons, Rabbits, Receptors, Immunologic, Receptors, LDL, Subcellular Fractions, Neurites, Receptors, Lipoprotein, Molecular Chaperones, Low Density Lipoprotein Receptor-Related Protein-1, LDL-Receptor Related Protein-Associated Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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