Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model
Open accessAbstract
Aberrant tau protein accumulation drives neurofibrillary tangle (NFT) formation in several neurodegenerative diseases. Currently, efforts to elucidate pathogenic mechanisms and assess the efficacy of therapeutic targets are limited by constraints of existing models of tauopathy. In order to generate a more versatile mouse model of tauopathy, somatic brain transgenesis was utilized to deliver adeno-associated virus serotype 1 (AAV1) encoding human mutant P301L-tau compared with GFP control. At 6 months of age, we observed widespread human tau expression with concomitant accumulation of hyperphosphorylated and abnormally folded proteinase K resistant tau. However, no overt neuronal loss was observed, though significant abnormalities were noted in the postsynaptic scaffolding protein PSD95. Neurofibrillary pathology was also detected with Gallyas silver stain and Thioflavin-S, and electron microscopy revealed the deposition of closely packed filaments. In addition to classic markers of tauopathy, significant neuroinflammation and extensive gliosis were detected in AAV1-Tau(P301L) mice. This model also recapitulates the behavioral phenotype characteristic of mouse models of tauopathy, including abnormalities in exploration, anxiety, and learning and memory. These findings indicate that biochemical and neuropathological hallmarks of tauopathies are accurately conserved and are independent of cell death in this novel AAV-based model of tauopathy, which offers exceptional versatility and speed in comparison with existing transgenic models. Therefore, we anticipate this approach will facilitate the identification and validation of genetic modifiers of disease, as well as accelerate preclinical assessment of potential therapeutic targets.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microgliosis, astrogliosis and inflammatory markers like IL-β, TNF-α and IL-6 have been shown to increase in response to tau pathology.
“Furthermore, microgliosis, astrogliosis and inflammatory markers like IL-β, TNF-α and IL-6 have been shown increase in response to tau pathology [171].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [171]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 1× · see citing works
“4), denoting argyrophilic lesions (20) and the adoptionof β-pleated sheet structure (21), respectively.”
BackgroundAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · see citing works
Self-citationA Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409 · see citing works
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works
Self-citationNeuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295 · see citing works
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works
Self-citationGenome-wide association study reveals genetic risk underlying Parkinson's disease
Simón‐Sánchez, J., Schulte, C., Brás, J., Sharma, M., Gibbs, J. R., Berg, D., Paisán‐Ruiz, C., Lichtner, P., Scholz, S. W., Hernandez, D. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.487 · Cited by 1,916 · see citing works
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · see citing works
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380 · see citing works
Tau is a candidate gene for chromosome 17 frontotemporal dementia
Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · see citing works
Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371 · see citing works
Self-citationGoldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X.-L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003716 · Cited by 958 · see citing works
Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
Petrucelli, L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh083 · Cited by 735 · see citing works
Self-citationKitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697 · see citing works
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Bhaskar, K., Konerth, M., Kokiko-Cochran, O. N., Cardona, A., Ransohoff, R. M., & Lamb, B. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.023 · Cited by 639 · see citing works
Maphis, N., Xu, G., Kokiko-Cochran, O. N., Jiang, S., Cardona, A., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Brain · doi:10.1093/brain/awv081 · Cited by 595 · see citing works
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
Andorfer, C., Acker, C. M., Kress, Y., Hof, P. R., Duff, K., & Davies, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4637-04.2005 · Cited by 511 · cited 1× · see citing works
“loss in our AAV-based model is in agreement with reports in other tau models, including the rTg4510 and humanized tau mousemodels (50,51), although future studieswill need to assess whether neuronal loss is observed in the AAV1-Tau model beyond 6 months of age.”
ResultInterleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices
Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works
C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
Chew, J., Gendron, T. F., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes‐Casey, M., Lee, C. W., Jansen‐West, K. R., Kurti, A., Murray, M. E., et al. (2015) · Science · doi:10.1126/science.aaa9344 · Cited by 410 · see citing works
Self-citationSpires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H., & Hyman, B. T. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050840 · Cited by 401 · see citing works
Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400 · see citing works
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-151 · Cited by 400 · see citing works
Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies
Ishizawa, T., Mattila, P. M., Davies, P., Wang, D., & Dickson, D. W. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.389 · Cited by 391 · see citing works
Self-citationCripps, D., Thomas, S. N., Jeng, Y., Yang, F., Davies, P., & Yang, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512786200 · Cited by 312 · see citing works
Conformational change as one of the earliest alterations of tau in Alzheimer's disease
Weaver, C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00157-3 · Cited by 310 · see citing works
Tatebayashi, Y., Miyasaka, T., Chui, D., Akagi, T., Mishima, K., Iwasaki, K., Fujiwara, M., Tanemura, K., Murayama, M., Ishiguro, K., et al. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.202205599 · Cited by 279 · see citing works
Concurrence of α-synuclein and tau brain pathology in the Contursi kindred
Duda, J. E., Giasson, B. I., Mabon, M. E., Miller, D. C., Golbe, L. I., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0563-3 · Cited by 274 · see citing works
Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
Jellinger, K. A., & Attems, J. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0347-5 · Cited by 265 · see citing works
Takeuchi, H., Iba, M., Inoue, H., Higuchi, M., Takao, K., Tsukita, K., Karatsu, Y., Iwamoto, Y., Miyakawa, T., Suhara, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021050 · Cited by 247 · see citing works
Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau
Tanemura, K., Murayama, M., Akagi, T., Hashikawa, T., Tominaga, T., Ichikawa, M., Yamaguchi, H., & Takashima, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00133.2002 · Cited by 243 · see citing works
Coppola, G., Chinnathambi, S., Lee, J. J., Dombroski, B. A., Baker, M. C., Soto-Ortolaza, A. I., Lee, S. E., Klein, E., Huang, A. Y., Sears, R., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds161 · Cited by 240 · see citing works
Self-citationAkt and CHIP coregulate tau degradation through coordinated interactions
Dickey, C. A., Koren, J., Zhang, Y.-J., Xu, Y.-F., Jinwal, U. K., Birnbaum, M. J., Monks, B., Sun, M., Cheng, J. Q., Patterson, C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709180105 · Cited by 226 · see citing works
Self-citationShao, C. Y., Mirra, S. S., Sait, H. B. R., Sacktor, T. C., & Sigurdsson, E. M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0843-x · Cited by 219 · see citing works
Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment
Forlenza, O. V., Diniz, B. S., Talib, L. L., Mendonça, V. A., Ojopi, E. P. B., Gattaz, W. F., & Teixeira, A. L. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000255051 · Cited by 218 · see citing works
Microglia in neurodegeneration: Molecular aspects
Gebicke‐Haerter, P. J. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1120 · Cited by 212 · see citing works
Wills, J., Jones, J. M., Haggerty, T., Duka, V., Joyce, J. N., & Sidhu, A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.06.017 · Cited by 211 · see citing works
Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease
Galimberti, D., Fenoglio, C., Lovati, C., Venturelli, E., Guidi, I., Corrà, B., Scalabrini, D., Clerici, F., Mariani, C., Bresolin, N., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.007 · Cited by 209 · see citing works
Ishizawa, K., & Dickson, D. W. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.6.647 · Cited by 209 · see citing works
Self-citationCapsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
Chakrabarty, P., Rosario, A. M., Cruz, P. E., Siemienski, Z. B., Ceballos‐Diaz, C., Crosby, K. W., Jansen, K. R., Borchelt, D., Kim, J., Jankowsky, J. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067680 · Cited by 201 · see citing works
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
Rocher, A. B., Crimins, J. L., Amatrudo, J. M., Kinson, M. S., Todd-Brown, M. A., Lewis, J., & Luebke, J. I. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.029 · Cited by 187 · see citing works
Kotzbauer, P. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.007 · Cited by 176 · see citing works
Gerhard, A., Trender‐Gerhard, I., Turkheimer, F., Quinn, N. P., Bhatia, K. P., & Brooks, D. J. (2006) · Movement Disorders · doi:10.1002/mds.20668 · Cited by 171 · see citing works
Cacabelos, R., Barquero, M. S., Garcia, P. E., Alvarez, X. A., & de Seijas, E. V. (1991) · PubMed · Cited by 148 · see citing works
Yen, S. H., Dickson, D. W., Crowe, A., Butler, M., & Shelanski, M. L. (1987) · PubMed Central · Cited by 147 · see citing works
Self-citationMuntané, G., Dalfó, E., Martı́nez, A., & Ferrer, I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.030 · Cited by 143 · see citing works
Dumont, M., Stack, C., Elipenahli, C., Jainuddin, S., Gerges, M., Starkova, N. N., Yang, L., Starkov, A. A., & Beal, F. M. (2011) · The FASEB Journal · doi:10.1096/fj.11-186650 · Cited by 139 · see citing works
Crimins, J. L., Rocher, A. B., & Luebke, J. I. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1038-9 · Cited by 137 · see citing works
Gascón, S., Sobrado, M., Roda, J. M., Rodríguez‐Peña, A., & Díaz‐Guerra, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002017 · Cited by 129 · see citing works
Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles
Galloway, P. G., Grundke, I., Iqbal, K., & Perry, G. L. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198811000-00008 · Cited by 129 · see citing works
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
Cook, C. N., Gendron, T. F., Scheffel, K., Carlomagno, Y., Dunmore, J. H., Deture, M. A., & Petrucelli, L. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds125 · Cited by 129 · see citing works
Self-citationPickering-Brown, S. M., Richardson, A. M. T., Snowden, J. S., McDonagh, A. M., Burns, A. S., Braude, W., Baker, M., Liu, W. ‐., Yen, S. H., Hardy, J., et al. (2002) · Brain · doi:10.1093/brain/awf069 · Cited by 124 · see citing works
Wes, P. D., Easton, A. E., Corradi, J., Barten, D. M., Devidze, N., DeCarr, L. B., Truong, A. B., He, A., Barrezueta, N. X., Polson, C. T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106050 · Cited by 105 · see citing works
Lin, W.-L., Lewis, J. M., Yen, S.-H. C., Hutton, M. L., & Dickson, D. W. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63812-6 · Cited by 100 · see citing works
Self-citationRao, M. V., McBrayer, M. K., Campbell, J., Kumar, A., Hashim, A. T., Sershen, H. W., Stavrides, P. H., Ohno, M., Hutton, M., & Nixon, R. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1132-14.2014 · Cited by 99 · see citing works
Early behavioural markers of disease in P301S tau transgenic mice
Scattoni, M. L., Gasparini, L., Alleva, E., Goedert, M., Calamandrei, G., & Spillantini, M. G. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.002 · Cited by 98 · see citing works
Mutations in progranulin explain atypical phenotypes with variants in MAPT
Pickering-Brown, S. M., Baker, M., Gass, J. M., Boeve, B. F., Loy, C. T., Brooks, W. S., Mackenzie, I. R., Martins, R. N., Kwok, J. B., Halliday, G. M., et al. (2006) · Brain · doi:10.1093/brain/awl289 · Cited by 98 · see citing works
Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion
Bieniek, K. F., Murray, M. E., Rutherford, N. J., Castanedes‐Casey, M., DeJesus‐Hernandez, M., Liesinger, A. M., Baker, M., Boylan, K., Rademakers, R., & Dickson, D. W. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1048-7 · Cited by 94 · see citing works
Self-citationCharacteristics of Tau Oligomers
Ren, Y., & Sahara, N. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00102 · Cited by 85 · see citing works
Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides.
Yen, S. H., Crowe, A., & Dickson, D. W. (1985) · PubMed Central · Cited by 84 · see citing works
Self-citationNovel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration
Kouri, N., Carlomagno, Y., Baker, M., Liesinger, A. M., Caselli, R. J., Wszołek, Z. K., Petrucelli, L., Boeve, B. F., Parisi, J. E., Josephs, K. A., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1193-7 · Cited by 82 · see citing works
Self-citationCalpain-mediated degradation of PSD-95 in developing and adult rat brain
Lü, X., Rong, Y., & Baudry, M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01101-0 · Cited by 80 · see citing works
Dickson, D. W., Ksiȩżak-Reding, H., Liu, W.-K., Davies, P., Crowe, A., & Yen, S. H. (1992) · Acta Neuropathologica · doi:10.1007/bf00227736 · Cited by 77 · see citing works
Self-citationKing, A., Al‐Sarraj, S., Troakes, C., Smith, B. N., Maekawa, S., Iovino, M., Spillantini, M. G., & Shaw, C. E. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1050-0 · Cited by 76 · see citing works
Dementia with Lewy bodies from the perspective of tauopathy
Iseki, E., Togo, T., Suzuki, K., Katsuse, O., Marui, W., de Silva, R., Lees, A. J., Yamamoto, T., & Kosaka, K. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0644-3 · Cited by 70 · see citing works
Taniguchi, T., Doe, N., Matsuyama, S., Kitamura, Y., Mori, H., Saito, N., & Tanaka, C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.047 · Cited by 60 · see citing works
Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia
Cook, C. N., Dunmore, J. H., Murray, M. E., Scheffel, K., Shukoor, N., Tong, J., Castanedes‐Casey, M., Phillips, V. R., Rousseau, L., Penuliar, M. S., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.023 · Cited by 59 · see citing works
Self-citationCorticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia
Josephs, K. A., Whitwell, J. L., Murray, M. E., Parisi, J. E., Graff‐Radford, N. R., Knopman, D. S., Boeve, B. F., Senjem, M. L., Rademakers, R., Jack, C. R., et al. (2013) · Brain · doi:10.1093/brain/aws324 · Cited by 47 · see citing works
Self-citationLee, S. E., Tartaglia, M. C., Yener, G., Genç, Ş., Seeley, W. W., Sánchez‐Juan, P., Moreno, F., Mendez, M. F., Klein, E., Rademakers, R., et al. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31828cc357 · Cited by 45 · see citing works
Muntané, G., Dalfó, E., Martínez, A., & Ferrer, I. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70717-x · Cited by 40 · see citing works
Ludvigson, A. E., Luebke, J. I., Lewis, J. M., & Peters, A. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0295-4 · Cited by 27 · see citing works
Novel MAPT Val75Ala mutation and PSEN2 Arg62Hys in two siblings with frontotemporal dementia
Gallo, M., Tomaino, C., Puccio, G., Frangipane, F., Curcio, S. A. M., Bernardi, L., Geracitano, S., Anfossi, M., Mirabelli, M., Colao, R., et al. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0132-9 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Glial contributions to neurodegeneration in tauopathies
Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409 · see citing works
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Kang, S. S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J.-P., Petrucelli, L., & Fryer, J. D. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180653 · Cited by 260 · see citing works
“Viral production and injections were performed as described (Cook et al., 2015).”
MethodSelf-citationAPOE ε2 is associated with increased tau pathology in primary tauopathy
Zhao, N., Liu, C.-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06783-0 · Cited by 139 · see citing works
Self-citationAn acetylation–phosphorylation switch that regulates tau aggregation propensity and function
Carlomagno, Y., Chung, D.-E. C., Yue, M., Castanedes-Casey, M., Madden, B. J., Dunmore, J., Tong, J., DeTure, M., Dickson, D. W., Petrucelli, L., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794602 · Cited by 143 · see citing works
Self-citationBehavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal
Kang, S. S., Kurti, A., Baker, K. E., Liu, C.-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G., & Fryer, J. D. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddx366 · Cited by 62 · see citing works
Self-citationNetwork analysis identifies strain-dependent response to tau and tau seeding-associated genes
Acri, D. J., You, Y., Tate, M. D., Karahan, H., Martinez, P., McCord, B., Sharify, A. D., John, S., Kim, B., Dabin, L. C., et al. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20230180 · Cited by 3 · see citing works
“We used an AAV-mediated gene expression model, as described before (Carlomagno et al., 2019; Cook et al., 2015; Kim et al., 2008).”
Influential
- Authors
- Cook, C., Kang, S. S., Carlomagno, Y., Lin, W.-L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G., Dickson, D. W., Petrucelli, L., & Fryer, J. D.
- Affiliations
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Corresponding author
- Petrucelli, Leonard
- Fryer, John D.
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-08-13
- Volume
- 24
- Issue
- 21
- Pages
- 6198-6212
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC4599677
- OpenAlex
- W2143786056
- Cited by
- 82
- References
- 76
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 10 · 2018: 6 · 2017: 12 · 2016: 5
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Human Molecular Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Mayo Clinic Foundation
- National Institutes of Health/National Institute on Aging (ADRC 2 P50 AG016574-16)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS089544)
- BrightFocus Foundation (A2013546S)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tauopathy, tau protein, P301L tau, neurofibrillary tangles, mouse model, neuroinflammation, gliosis, PSD-95, hyperphosphorylated tau, anxiety, learning and memory, behavioral phenotypes, neuronal loss
- MeSH terms
- Animals, Behavior, Animal, Brain, Disease Models, Animal, Humans, Mice, Transgenic, Neurons, Ultrasonography, Neurofibrillary Tangles, tau Proteins, Cell Death, Tauopathies, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
