Nussler, Andreas K.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

Nussler, A. K., Di Silvio, M., Billiar, T. R., Hoffman, R. A., Geller, D. A., Selby, R., Madariaga, J., & Simmons, R. L. (1992) · The Journal of Experimental Medicine

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 420

Crucial Role of Vitamin D in the Musculoskeletal System

Wintermeyer, E., Ihle, C., Ehnert, S., Stöckle, U., Ochs, G., De Zwart, P., Flesch, I., Bahrs, C., & Nussler, A. (2016) · Nutrients

Vitamin D Research StudiesBone health and osteoporosis research

Cited by 216

Induction of nitric oxide synthesis and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS

Nussler, A. K., Geller, D. A., Sweetland, M. A., Disilvio, M., Billiar, T. R., Madariaga, J. B., Simmons, R. L., & Lancaster, J. R. (1993) · Biochemical and Biophysical Research Communications

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 90

Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke

Aspera-Werz, R. H., Ehnert, S., Heid, D., Zhu, S., Chen, T., Braun, B., Sreekumar, V., Arnscheidt, C., & Nussler, A. K. (2018) · Oxidative Medicine and Cellular Longevity

Bone Metabolism and DiseasesRedox biology and oxidative stress

Cited by 90

Towards improved hepatocyte cultures: Progress and limitations

Ruoß, M., Vosough, M., Königsrainer, A., Nadalin, S., Wagner, S., Sajadian, S., Huber, D., Heydari, Z., Ehnert, S., Hengstler, J. G., et al. (2020) · Food and Chemical Toxicology

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 77

3D Cultivation Techniques for Primary Human Hepatocytes

Bachmann, A., Moll, M., Gottwald, E., Nies, C., Zantl, R., Wagner, H., Burkhardt, B., Sánchez, J., Ladurner, R., Thasler, W., et al. (2015) · Microarrays

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 59

Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells

Aspera-Werz, R. H., Chen, T., Ehnert, S., Zhu, S., Fröhlich, T., & Nussler, A. K. (2019) · International Journal of Molecular Sciences

TGF-β signaling in diseasesMesenchymal stem cell research

Cited by 58

The relationship between healthy lifestyles and bone health: A narrative review

Sheng, B., Li, X., Nussler, A. K., & Zhu, S. (2021) · Medicine

Bone health and osteoporosis researchBone Metabolism and Diseases

Cited by 46

Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty

Ehnert, S., Aspera-Werz, R. H., Ihle, C., Trost, M., Zirn, B., Flesch, I., Schröter, S., Relja, B., & Nussler, A. K. (2019) · Journal of Clinical Medicine

Total Knee Arthroplasty OutcomesOrthopedic Infections and Treatments

Cited by 45

Bisphosphonates Reduce Smoking-Induced Osteoporotic-Like Alterations by Regulating RANKL/OPG in an Osteoblast and Osteoclast Co-Culture Model

Zhu, S., Häussling, V., Aspera-Werz, R. H., Chen, T., Braun, B., Weng, W., Histing, T., & Nussler, A. K. (2020) · International Journal of Molecular Sciences

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 42

Increased oxidative stress in the RAW 264.7 macrophage cell line is partially mediated via the S‐nitrosothiol‐induced inhibition of glutathione reductase

Butzer, U., Weidenbach, H., Gansauge, S., Gansauge, F., Beger, H. G., & Nussler, A. K. (1999) · FEBS Letters

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 40

Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

Ruoß, M., Damm, G., Vosough, M., Ehret, L., Grom-Baumgarten, C., Petkov, M., Naddalin, S., Ladurner, R., Seehofer, D., Nussler, A., et al. (2019) · International Journal of Molecular Sciences

Pharmacogenetics and Drug MetabolismEpigenetics and DNA Methylation

Cited by 37

Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes

Aspera-Werz, R. H., Ehnert, S., Müller, M., Zhu, S., Chen, T., Weng, W., Jacoby, J., & Nussler, A. K. (2020) · World Journal of Stem Cells

Smoking Behavior and CessationBone Tissue Engineering Materials

Cited by 24