McMahon, Michael

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressEndoplasmic Reticulum Stress and Disease

Cited by 1,472

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,141

SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 759

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene

Genomics, phytochemicals, and oxidative stressUbiquitin and proteasome pathways

Cited by 657

Chronic pancreatitis

Braganza, J. M., Lee, S. H., McCloy, R. F., & McMahon, M. J. (2011) · The Lancet

Pancreatitis Pathology and TreatmentIgG4-Related and Inflammatory Diseases

Cited by 469

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

CHANAS, S. A., JIANG, Q., McMAHON, M., McWALTER, G. K., McLELLAN, L. I., ELCOMBE, C. R., HENDERSON, C. J., WOLF, C. R., MOFFAT, G. J., ITOH, K., et al. (2002) · Biochemical Journal

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 460

Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

Bernhardt, J., Churilov, L., Ellery, F., Collier, J., Chamberlain, J., Langhorne, P., Lindley, R. I., Moodie, M., Dewey, H., Thrift, A. G., et al. (2016) · Neurology

Stroke Rehabilitation and RecoveryAcute Ischemic Stroke Management

Cited by 221