Bluestone, Jeffrey A.

Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody

Perez, P., Hoffman, R. W., Shaw, S., Bluestone, J. A., & Segal, D. M. (1985) · Nature

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 337

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation

DuPage, M., Chopra, G., Quiros, J., Rosenthal, W. L., Morar, M. M., Holohan, D., Zhang, R., Turka, L., Marson, A., & Bluestone, J. A. (2015) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 332

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

Wang, D., Quiros, J., Mahuron, K., Pai, C.-C., Ranzani, V., Young, A., Silveria, S., Harwin, T., Abnousian, A., Pagani, M., et al. (2018) · Cell Reports

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 318

Discovery of stimulation-responsive immune enhancers with CRISPR activation

Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., Satpathy, A. T., Lee, Y., Bray, N. L., Chan, A. Y., et al. (2017) · Nature

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 297

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

Masteller, E. L., Warner, M. R., Tang, Q., Tarbell, K. V., McDevitt, H., & Bluestone, J. A. (2005) · The Journal of Immunology

T-cell and B-cell ImmunologyDiabetes and associated disorders

Cited by 260

New frontiers in the treatment of type 1 diabetes

Warshauer, J. T., Bluestone, J. A., & Anderson, M. S. (2020) · Cell Metabolism

Diabetes and associated disordersDiabetes Management and Research

Cited by 259

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

Herold, K. C., Vignali, D. A. A., Cooke, A., & Bluestone, J. A. (2013) · Nature Reviews Immunology

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 237

How Does Type 1 Diabetes Develop?

Atkinson, M. A., Bluestone, J. A., Eisenbarth, G. S., Hebrok, M., Herold, K. C., Accili, D., Pietropaolo, M., Arvan, P. R., Von Herrath, M., Markel, D. S., et al. (2011) · Diabetes

Diabetes and associated disordersPancreatic function and diabetes

Cited by 232

Treatment of patients with new onset type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

Herold, K. C., Gitelman, S., Greenbaum, C., Puck, J., Hagopian, W., Gottlieb, P., Sayre, P., Bianchine, P., Wong, E., Seyfert-Margolis, V., et al. (2009) · Clinical Immunology

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 219

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

Roth, T. L., Li, P. J., Blaeschke, F., Nies, J. F., Apathy, R., Mowery, C., Yu, R., Nguyen, M. L. T., Lee, Y., Truong, A., et al. (2020) · Cell

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 186

Exendin-4 Improves Reversal of Diabetes in NOD Mice Treated with Anti-CD3 Monoclonal Antibody by Enhancing Recovery of β-Cells

Sherry, N. A., Chen, W., Kushner, J. A., Glandt, M., Tang, Q., Tsai, S., Santamaria, P., Bluestone, J. A., Brillantes, A.-M. B., & Herold, K. C. (2007) · Endocrinology

Diabetes and associated disordersPancreatic function and diabetes

Cited by 169

T cells in the control of organ-specific autoimmunity

Bluestone, J. A., Bour-Jordan, H., Cheng, M., & Anderson, M. (2015) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 155

Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases

Chuang, E., Lee, K.-M., Robbins, M. D., Duerr, J. M., Alegre, M.-L., Hambor, J. E., Neveu, M. J., Bluestone, J. A., & Thompson, C. B. (1999) · The Journal of Immunology

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 119

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., Le, D. T., Liu, W., Brusko, T. M., Anderson, M. S., et al. (2019) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 102

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Esensten, J. H., Bluestone, J. A., & Lim, W. A. (2017) · Annual Review of Pathology: Mechanisms of Disease

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 62

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

Bluestone, J. A., & Tang, Q. (2020) · Cell Stem Cell

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 16