Vergnolle, Nathalie

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 591

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Patel, H. H., et al. (2022) · British Journal of Pharmacology

Statistical Methods in Clinical TrialsAnimal testing and alternatives

Cited by 520

Protease-activated receptors in inflammation, neuronal signaling and pain

Vergnolle, N., Wallace, J. L., Bunnett, N. W., & Hollenberg, M. D. (2001) · Trends in Pharmacological Sciences

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 369

The Intestinal Microenvironment and Functional Gastrointestinal Disorders

Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology

Gastrointestinal motility and disordersGut microbiota and health

Cited by 335

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., et al. (2012) · Science Translational Medicine

Probiotics and Fermented FoodsInflammatory Bowel Disease

Cited by 257

Protease inhibition as new therapeutic strategy for GI diseases

Vergnolle, N. (2016) · Gut

Protease and Inhibitor MechanismsInflammatory Bowel Disease

Cited by 226

Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability

Chin, A. C., Vergnolle, N., MacNaughton, W. K., Wallace, J. L., Hollenberg, M. D., & Buret, A. G. (2003) · Proceedings of the National Academy of Sciences

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 149

PAR 2 activation alters colonic paracellular permeability in mice via IFN‐γ‐dependent and ‐independent pathways

Cenac, N., Chin, A. C., Garcia‐Villar, R., Salvador‐Cartier, C., Ferrier, L., Vergnolle, N., Buret, A. G., Fioramonti, J., & Bueno, L. (2004) · The Journal of Physiology

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 140

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

Caminero, A., McCarville, J. L., Galipeau, H. J., Deraison, C., Bernier, S. P., Constante, M., Rolland, C., Meisel, M., Murray, J. A., Yu, X. B., et al. (2019) · Nature Communications

Celiac Disease Research and ManagementGut microbiota and health

Cited by 139

Proteinase-Activated Receptor-2-Induced Colonic Inflammation in Mice: Possible Involvement of Afferent Neurons, Nitric Oxide, and Paracellular Permeability

Cenac, N., Garcia-Villar, R., Ferrier, L., Larauche, M., Vergnolle, N., Bunnett, N. W., Coelho, A.-M., Fioramonti, J., & Bueno, L. (2003) · The Journal of Immunology

Gastrointestinal motility and disordersBlood Coagulation and Thrombosis Mechanisms

Cited by 139

Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

Motta, J., Magne, L., Descamps, D., Rolland, C., Squarzoni–Dale, C., Rousset, P., Martin, L., Cenac, N., Balloy, V., Huerre, M., et al. (2011) · Gastroenterology

Inflammatory Bowel DiseaseProtease and Inhibitor Mechanisms

Cited by 130

Epithelial expression and function of trypsin-3 in irritable bowel syndrome

Rolland-Fourcade, C., Denadai-Souza, A., Cirillo, C., Lopez, C., Jaramillo, J. O., Desormeaux, C., Cenac, N., Motta, J.-P., Larauche, M., Taché, Y., et al. (2017) · Gut

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 126

Neurons and Glia in the Enteric Nervous System and Epithelial Barrier Function

Vergnolle, N., & Cirillo, C. (2018) · Physiology

Gastrointestinal motility and disordersCongenital gastrointestinal and neural anomalies

Cited by 106

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

Boué, J., Basso, L., Cenac, N., Blanpied, C., Rolli–Derkinderen, M., Neunlist, M., Vergnolle, N., & Dietrich, G. (2014) · Gastroenterology

Inflammatory Bowel DiseasePain Mechanisms and Treatments

Cited by 104

Protease‐activated receptor‐4 (PAR4): a role as inhibitor of visceral pain and hypersensitivity

Augé, C., Balz‐hara, D., Steinhoff, M., Vergnolle, N., & Cenac, N. (2009) · Neurogastroenterology & Motility

Pain Mechanisms and TreatmentsIon Channels and Receptors

Cited by 99

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Denadai-Souza, A., Bonnart, C., Tapias, N. S., Marcellin, M., Gilmore, B., Alric, L., Bonnet, D., Burlet-Schiltz, O., Hollenberg, M. D., Vergnolle, N., et al. (2018) · Scientific Reports

Protease and Inhibitor MechanismsInflammatory Bowel Disease

Cited by 91

Development, plasticity and modulation of visceral afferents

Christianson, J. A., Bielefeldt, K., Altier, C., Cenac, N., Davis, B. M., Gebhart, G. F., High, K. W., Kollarik, M., Randich, A., Undem, B., et al. (2009) · Brain Research Reviews

Pain Mechanisms and TreatmentsIon Channels and Receptors

Cited by 80

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn’s disease

Coquenlorge, S., Van Landeghem, L., Jaulin, J., Cenac, N., Vergnolle, N., Duchalais, E., Neunlist, M., & Rolli-Derkinderen, M. (2016) · Scientific Reports

Inflammatory Bowel DiseaseInflammatory mediators and NSAID effects

Cited by 48

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Motta, J.-P., Rolland, C., Edir, A., Florence, A.-C., Sagnat, D., Bonnart, C., Rousset, P., Guiraud, L., Quaranta-Nicaise, M., Mas, E., et al. (2021) · Mucosal Immunology

Inflammatory Bowel DiseaseProtease and Inhibitor Mechanisms

Cited by 40