Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis
Abstract
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Crohn's disease and ulcerative colitis patients, increased host serine protease production from colonic tissue has been reported.
“In both CD and UC patients, increased host serine protease production from colonic tissue have been reported.27,28”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Inhibitors of serine proteases have beneficial effects in mouse models of inflammatory bowel disease.
“Consistent with a role of proteolytic overactivity in disease pathogenesis, inhibitors of serine proteases have beneficial effects in mouse models of IBD.27,30”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Elafin, a Lactobacillus-derived inhibitor of serine proteases, reduces the severity of colitis in mice exposed to dextran sulfate sodium or trinitro benzene sulphonic acid.
“Elafin, a Lactobacillus-derived inhibitor of serine proteases reduced the severity of colitis in mice exposed to dextran sulfate sodium (DSS) or trinitro benzene sulphonic acid.27,30,31”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [27]
Cites
Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513 · see citing works
A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease
Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786 · see citing works
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613 · see citing works
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 1× · see citing works
“Indeed, elevated proteolytic activity has been detected in intestinal tissues from CD and UC patients (5, 6).”
BackgroundSelf-citationSteidler, L., Neirynck, S., Huyghebaert, N., Snoeck, V., Vermeire, A., Goddeeris, B. M., Cox, E., Remon, J. P., & Remaut, E. (2003) · Nature Biotechnology · doi:10.1038/nbt840 · Cited by 545 · see citing works
Wiedow, O., Schröder, J. M., Gregory, H., Young, J. A., & Christophers, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77182-2 · Cited by 433 · see citing works
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cénac, N., Coelho, A., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W., Wallace, J., Hollenberg, M., Bunnett, N., Garcia-Villar, R., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64466-5 · Cited by 386 · see citing works
Self-citationRole of the microbiota in inflammatory bowel diseases
Nagalingam, N. A., & Lynch, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21866 · Cited by 315 · see citing works
Bermúdez‐Humarán, L. G., Cortes‐Perez, N. G., Lefèvre, F., Guimarães, V., Rabot, S., Alcocer-González, J. M., Gratadoux, J., Rodrı́guez-Padilla, C., Taméz-Guerra, R. S., Corthier, G., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7297 · Cited by 191 · see citing works
Self-citationCLINICAL RELEVANCE OF PROTEINASE ACTIVATED RECEPTORS (PARS) IN THE GUT
Vergnolle, N. (2005) · Gut · doi:10.1136/gut.2004.048876 · Cited by 166 · see citing works
Self-citationHenriksen, P. A., Hitt, M., Xing, Z., Wang, J., Haslett, C., Riemersma, R. A., Webb, D. J., Kotelevtsev, Y. V., & Sallenave, J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4535 · Cited by 143 · see citing works
Self-citationReview article: proteinase‐activated receptors — novel signals for gastrointestinal pathophysiology
Vergnolle, N. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00690.x · Cited by 135 · see citing works
Self-citationWatterlot, L., Rochat, T., Sokol, H., Cherbuy, C., Bouloufa, I., Lefèvre, F., Gratadoux, J., Honvo‐Houeto, E., Chilmonczyk, S., Blugeon, S., et al. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.03.037 · Cited by 134 · see citing works
Self-citationRochat, T., Bermúdez‐Humarán, L. G., Gratadoux, J., Fourage, C., Hoebler, C., Corthier, G., & Langella, P. (2007) · Microbial Cell Factories · doi:10.1186/1475-2859-6-22 · Cited by 132 · see citing works
Self-citationSecretory Leukocyte Protease Inhibitor and Elafin/Trappin-2
Sallenave, J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0095rt · Cited by 130 · see citing works
Self-citationModifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis
Motta, J., Magne, L., Descamps, D., Rolland, C., Squarzoni–Dale, C., Rousset, P., Martin, L., Cenac, N., Balloy, V., Huerre, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.050 · Cited by 130 · see citing works
Self-citationBonnart, C., Deraison, C., Lacroix, M., Uchida, Y., Besson‐Fournier, C., Robin, A., Briot, A., Gonthier, M., Lamant, L., Dubus, P. R., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41440 · Cited by 128 · see citing works
Self-citationProtease-activated receptors as drug targets in inflammation and pain
Vergnolle, N. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.004 · Cited by 124 · see citing works
Self-citationSchmid, M., Fellermann, K., Fritz, P., Wiedow, O., Stange, E. F., & Wehkamp, J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906581 · Cited by 116 · see citing works
Grimoud, J., Durand, H., Souza, S. D. M. P., MONSAN, P. F., Ouarné, F., Théodorou, V., & Roques, C. G. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.09.007 · Cited by 114 · see citing works
Chin, A. C., Lee, W. Y., Nusrat, A., Vergnolle, N., & Parkos, C. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5702 · Cited by 106 · see citing works
Self-citationProtease-activated receptor-2 activation: a major actor in intestinal inflammation
Hyun, E., Andrade‐Gordon, P., Steinhoff, M. S., & Vergnolle, N. (2008) · Gut · doi:10.1136/gut.2008.150722 · Cited by 106 · see citing works
Self-citationSallenave, J., & RYLE, A. P. (1991) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1991.372.1.13 · Cited by 95 · see citing works
Self-citationRecombinant lactic acid bacteria as mucosal biotherapeutic agents
Daniel, C., Roussel, Y., Kleerebezem, M., & Pot, B. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.05.002 · Cited by 93 · see citing works
Nieto, C., & Espinosa, M. (2003) · Plasmid · doi:10.1016/s0147-619x(03)00020-9 · Cited by 87 · see citing works
Butler, M. W., Robertson, I., Greene, C. M., O'Neill, S. J., Taggart, C. C., & McElvaney, N. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604844200 · Cited by 83 · see citing works
Therapeutic potential of human elafin
Shaw, L., & Wiedow, O. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391450 · Cited by 80 · see citing works
Guyot, N., Zani, M.-L., Maurel, M.-C., Dallet‐Choisy, S., & Moreau, T. (2005) · Biochemistry · doi:10.1021/bi051418i · Cited by 71 · see citing works
Therapeutic Drug Delivery by Genetically Modified Lactococcus lactis
Steidler, L., & Rottiers, P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.031 · Cited by 59 · see citing works
Cénac, N., Cellars, L., Steinhoff, M. S., Andrade‐Gordon, P., Hollenberg, M. D., Wallace, J. L., Fiorucci, S., & Vergnolle, N. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000177506.71784.bd · Cited by 58 · see citing works
Self-citationSallenave, J., Xing, Z., Simpson, A. J., Graham, F., & Gauldie, J. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300610 · Cited by 48 · see citing works
Self-citationChogle, A. S., Bu, H., Wang, X., Brown, J. B., Chou, P. M., & Tan, X. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00074 · Cited by 46 · see citing works
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders, from Rationale to Reality
Shanahan, F., & Collins, S. M. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.08.006 · Cited by 42 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · see citing works
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 934 · see citing works
Cao, F., Jin, L., Gao, Y., Ding, Y., Wen, H., Qian, Z., Zhang, C., Hong, L., Huang, Y., Zhang, J., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01346-x · Cited by 488 · see citing works
Engineering bacteria for diagnostic and therapeutic applications
Riglar, D. T., & Silver, P. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.172 · Cited by 460 · see citing works
Yu, L. C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0483-8 · Cited by 404 · see citing works
Microbiota and metabolic diseases
Pascale, A., Marchesi, N., Marelli, C., Coppola, A., Luzi, L., Govoni, S., Giustina, A., & Gazzaruso, C. (2018) · Endocrine · doi:10.1007/s12020-018-1605-5 · Cited by 423 · see citing works
Dysbiosis in Inflammatory Bowel Disease: Pathogenic Role and Potential Therapeutic Targets
Santana, P. T., Rosas, S. L. B., Ribeiro, B. E., Marinho, Y., & de Souza, H. S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073464 · Cited by 343 · see citing works
Microbiome therapeutics — Advances and challenges
Mimee, M., Citorik, R. J., & Lu, T. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.032 · Cited by 317 · see citing works
Martín, R., Chain, F., Miquel, S., Lu, J., Gratadoux, J.-J., Sokol, H., Verdu, E. F., Bercik, P., Bermúdez-Humarán, L. G., & Langella, P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440815.76627.64 · Cited by 284 · see citing works
Self-citationRole of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease
Martín, R., Miquel, S., Ulmer, J., Kechaou, N., Langella, P., & Bermúdez‐Humarán, L. G. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-71 · Cited by 269 · see citing works
Self-citationGut microbiota, host health, and polysaccharides
Xu, X., Xu, P., Ma, C., Tang, J., & Zhang, X. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.12.009 · Cited by 245 · see citing works
Emerging roles of the microbiome in cancer
Bultman, S. J. (2014) · Carcinogenesis · doi:10.1093/carcin/bgt392 · Cited by 239 · see citing works
Protease inhibition as new therapeutic strategy for GI diseases
Vergnolle, N. (2016) · Gut · doi:10.1136/gutjnl-2015-309147 · Cited by 226 · see citing works
Self-citationMicrobiota effects on cancer: From risks to therapies
Rea, D., Coppola, G., Palma, G., Barbieri, A., Luciano, A., Del Prete, P., Rossetti, S., Berretta, M., Facchini, G., Perdonà, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24681 · Cited by 208 · see citing works
Modulation of bone remodeling by the gut microbiota: A new therapy for osteoporosis
Lyu, Z., Hu, Y., Guo, Y., & Liu, D. (2023) · Bone Research · doi:10.1038/s41413-023-00264-x · Cited by 207 · see citing works
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Zheng, Q., Woehl, J. L., Kitamura, S., Santos‐Martins, D., Smedley, C. J., Li, G., Forli, S., Moses, J. E., Wolan, D. W., & Sharpless, K. B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909972116 · Cited by 200 · see citing works
Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
Galipeau, H. J., Caminero, A., Turpin, W., Bermudez-Brito, M., Santiago, A., Libertucci, J., Constante, M., Raygoza Garay, J. A., Rueda, G., Armstrong, S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.004 · Cited by 190 · see citing works
Martín, R., Chamignon, C., Mhedbi-Hajri, N., Chain, F., Derrien, M., Escribano-Vázquez, U., Garault, P., Cotillard, A., Pham, H., Chervaux, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41738-5 · Cited by 188 · see citing works
Self-citationProtectin D1 n-3 DPA and resolvin D5 n-3 DPA are effectors of intestinal protection
Gobbetti, T., Dalli, J., Colas, R. A., Canova, D. F., Aursnes, M., Bonnet, D., Alric, L., Vergnolle, N., Deraison, C., Hansen, T. V., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617290114 · Cited by 170 · see citing works
Self-citationEngineering lactococci and lactobacilli for human health
Bermúdez‐Humarán, L. G., Aubry, C., Motta, J., Deraison, C., Steidler, L., Vergnolle, N., Chatel, J., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.002 · Cited by 164 · see citing works
Self-citationCénac, N., Bautzová, T., Faouder, P. L., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand‐Michel, J., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.011 · Cited by 152 · see citing works
Self-citationMicrobiome therapeutics: exploring the present scenario and challenges
Yadav, M., & Chauhan, N. S. (2021) · Gastroenterology report · doi:10.1093/gastro/goab046 · Cited by 157 · see citing works
Cano‐Garrido, O., Seras‐Franzoso, J., & García‐Fruitós, E. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0313-6 · Cited by 148 · see citing works
Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications
Michon, C., Langella, P., Eijsink, V. G. H., Mathiesen, G., & Chatel, J. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0468-9 · Cited by 140 · see citing works
Self-citationThe microbiome and its potential as a cancer preventive intervention
Bultman, S. J. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.09.001 · Cited by 134 · see citing works
Bermúdez‐Humarán, L. G., Motta, J., Aubry, C., Kharrat, P., Martin, L., Sallenave, J., Deraison, C., Vergnolle, N., & Langella, P. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0198-4 · Cited by 128 · see citing works
Self-citationHuang, Y., Zhou, J., Wang, S., Xiong, J., Chen, Y., Liu, Y., Xiao, T., Li, Y., He, T., Li, Y., et al. (2020) · Theranostics · doi:10.7150/thno.45455 · Cited by 128 · see citing works
Epithelial expression and function of trypsin-3 in irritable bowel syndrome
Rolland-Fourcade, C., Denadai-Souza, A., Cirillo, C., Lopez, C., Jaramillo, J. O., Desormeaux, C., Cenac, N., Motta, J.-P., Larauche, M., Taché, Y., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-312094 · Cited by 126 · see citing works
Self-citationDrinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Liu, G. W., Pickett, M. J., Kuosmanen, J. L. P., Ishida, K., Madani, W. A. M., White, G. N., Jenkins, J. A., Park, S., Feig, V. R., Jiménez, M., et al. (2024) · Nature Materials · doi:10.1038/s41563-024-01811-5 · Cited by 125 · see citing works
Gut microbiome and anticancer immune response: really hot Sh*t!
Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123 · see citing works
Self-citationBenbouziane, B., Ribelles, P., Aubry, C., Martín, R., Kharrat, P., Riazi, A., Langella, P., & Bermúdez‐Humarán, L. G. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.04.019 · Cited by 115 · see citing works
Self-citationLactic acid bacteria as mucosal delivery vehicles: a realistic therapeutic option
Wang, M., Gao, Z., Zhang, Y., & Pan, L. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7557-x · Cited by 112 · see citing works
Liu, T., Song, X., Khan, S., Li, Y., Guo, Z., Li, C., Wang, S., Dong, W., Liu, W., Wang, B., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32563 · Cited by 106 · see citing works
Edwinson, A. L., Yang, L., Peters, S., Hanning, N., Jeraldo, P., Jagtap, P., Simpson, J. B., Yang, T.-Y., Kumar, P., Mehta, S., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01103-1 · Cited by 105 · see citing works
Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice
Boué, J., Basso, L., Cenac, N., Blanpied, C., Rolli–Derkinderen, M., Neunlist, M., Vergnolle, N., & Dietrich, G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.09.020 · Cited by 104 · see citing works
Self-citationSerine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS
Edogawa, S., Edwinson, A. L., Peters, S. A., Chikkamenahalli, L. L., Sundt, W., Graves, S., Gurunathan, S. V., Breen-Lyles, M., Johnson, S., Dyer, R., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317416 · Cited by 101 · see citing works
Martín, R., Martín, R., Chain, F., Chain, F., Miquel, S., Miquel, S., Natividad, J. M., Natividad, J. M., Sokol, H., Sokol, H., et al. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.28549 · Cited by 99 · see citing works
Self-citationFecal Serine Protease Profiling in Inflammatory Bowel Diseases
Jablaoui, A., Kriaa, A., Mkaouar, H., Akermi, N., Soussou, S., Wysocka, M., Wołoszyn, D., Amouri, A., Gargouri, A., Maguin, E., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00021 · Cited by 101 · see citing works
Oral delivery of bacteria: Basic principles and biomedical applications
Li, S., Jiang, W., Zheng, C., Shao, D., Liu, Y., Huang, S., Han, J., Ding, J., Tao, Y., & Li, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.011 · Cited by 95 · see citing works
Flavonoids as inhibitors of human neutrophil elastase
Jakimiuk, K., Gesek, J., Atanasov, A. G., & Tomczyk, M. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1927006 · Cited by 99 · see citing works
Next generation probiotics for human health: An emerging perspective
Jan, T., Negi, R., Sharma, B., Kumar, S., Singh, S., Rai, A. K., Shreaz, S., Rustagi, S., Chaudhary, N., Kaur, T., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35980 · Cited by 95 · see citing works
Engineering Diagnostic and Therapeutic Gut Bacteria
Landry, B. P., & Tabor, J. J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0020-2017 · Cited by 95 · see citing works
The potential of neutrophil elastase inhibitors as anti-inflammatory therapies
Henriksen, P. A. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000001 · Cited by 95 · see citing works
Pan, H., Sun, T., Cui, M., Ma, N., Yang, C., Liu, J., Pang, G., Liu, B., Li, L., Zhang, X., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c11536 · Cited by 93 · see citing works
The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Denadai-Souza, A., Bonnart, C., Tapias, N. S., Marcellin, M., Gilmore, B., Alric, L., Bonnet, D., Burlet-Schiltz, O., Hollenberg, M. D., Vergnolle, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26282-y · Cited by 91 · see citing works
Self-citationLeBlanc, J. G., Aubry, C., Cortes‐Perez, N. G., de LeBlanc, A. D. M., Vergnolle, N., Langella, P., Azevedo, V., Chatel, J., Miyoshi, A., & Bermúdez‐Humarán, L. G. (2013) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12159 · Cited by 86 · see citing works
Self-citationThe Prospects for the Therapeutic Implications of Genetically Engineered Probiotics
Mazhar, S. F., Afzal, M., Almatroudi, A., Munir, S., Ashfaq, U. A., Rasool, M., Raza, H., Munir, H. M. W., Rajoka, M. S. R., & Khurshid, M. (2020) · Journal of Food Quality · doi:10.1155/2020/9676452 · Cited by 85 · see citing works
Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides
Plavec, T. V., & Berlec, A. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09628-y · Cited by 84 · see citing works
Biotechnology of health-promoting bacteria
Douillard, F. P., & de Vos, W. M. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.03.008 · Cited by 92 · see citing works
Bacterially mediated drug delivery and therapeutics: Strategies and advancements
Wu, L., Bao, F., Li, L., Yin, X., & Hua, Z. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114363 · Cited by 79 · see citing works
Shigemori, S., Watanabe, T., Kudoh, K., Ihara, M., Nigar, S., Yamamoto, Y., Suda, Y., Sato, T., Kitazawa, H., & Shimosato, T. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0378-2 · Cited by 78 · see citing works
Shamoon, M., Martin, N. M., & O'Brien, C. L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104344 · Cited by 73 · see citing works
Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders
Galipeau, H. J., Wiepjes, M., Motta, J., Schulz, J. D., Jury, J., Natividad, J. M., Pinto-Sanchez, I., Sinclair, D., Rousset, P., Martín, R., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.48 · Cited by 72 · see citing works
Self-citationNew therapeutic avenues in ulcerative colitis: thinking out of the box
Torres, J., Danese, S., & Colombel, J. (2013) · Gut · doi:10.1136/gutjnl-2012-303959 · Cited by 72 · see citing works
Emerging Frontiers in Microbiome Engineering
Inda, M. E., Broset, E., Lu, T. K., & de la Fuente‐Núñez, C. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.08.007 · Cited by 73 · see citing works
McCarville, J. L., Dong, J., Caminero, A., Bermudez-Brito, M., Jury, J., Murray, J. A., Duboux, S., Steinmann, M., Delley, M., Tangyu, M., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01323-17 · Cited by 71 · see citing works
Self-citationPharmacological approaches in celiac disease
McCarville, J. L., Caminero, A., & Verdu, E. F. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.002 · Cited by 67 · see citing works
Mańko, A., Motta, J., Cotton, J. A., Feener, T. D., Oyeyemi, A., Vallance, B. A., Wallace, J. L., & Buret, A. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178647 · Cited by 65 · see citing works
Self-citationBacterial interference with canonical NFκB signalling
Johannessen, M., Askarian, F., Sangvik, M., & Sollid, J. E. (2013) · Microbiology · doi:10.1099/mic.0.069369-0 · Cited by 64 · see citing works
Faecal neutrophil elastase-antiprotease balance reflects colitis severity
Barry, R. E., Ruano‐Gallego, D., Radhakrishnan, S. T., Lovell, S., Yu, L., Kotik, O., Glegola-Madejska, I., Tate, E. W., Choudhary, J. S., Williams, H. R. T., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0235-4 · Cited by 63 · see citing works
Active thrombin produced by the intestinal epithelium controls mucosal biofilms
Motta, J., Denadai‐Souza, A., Sagnat, D., Guiraud, L., Edir, A., Bonnart, C., Sebbag, M., Rousset, P., Lapeyre, A., Séguy, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11140-w · Cited by 63 · see citing works
Self-citationSahoo, M., del Barrio, L., Miller, M. A., & Re, F. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004327 · Cited by 62 · see citing works
The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology
Buscarinu, M. C., Fornasiero, A., Romano, S., Ferraldeschi, M., Mechelli, R., Reniè, R., Morena, E., Romano, C., Pellicciari, G., Landi, A. C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01916 · Cited by 62 · see citing works
Immunomodulatory Effects of Lactobacillus Strains: Emphasis On Their Effects on Cancer Cells
Do, A. A., Taherian‐Esfahani, Z., Ghafouri‐Fard, S., Ghafouri-Fard, S., & Motevaseli, E. (2015) · Immunotherapy · doi:10.2217/imt.15.92 · Cited by 61 · see citing works
Synthetic Biology and the Gut Microbiome
Dou, J., & Bennett, M. R. (2017) · Biotechnology Journal · doi:10.1002/biot.201700159 · Cited by 61 · see citing works
Agus, A., Massier, S., Darfeuille–Michaud, A., Billard, E., & Barnich, N. (2014) · BioMed Research International · doi:10.1155/2014/567929 · Cited by 60 · see citing works
Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences
Beck, P. L., Cotton, J. A., Platnich, J. M., Muruve, D. A., Buret, A. G., & Jijon, H. B. (2016) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s63682 · Cited by 60 · see citing works
Synthetic Biology Approaches in the Development of Engineered Therapeutic Microbes
Kang, M., Choe, D., Kim, K., Cho, B., & Cho, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228744 · Cited by 58 · see citing works
Exploring the potential impact of probiotic use on drug metabolism and efficacy
Purdel, C. N., Ungurianu, A., Adam-Dima, I., & Margina, D. M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114468 · Cited by 63 · see citing works
Teng, G., Li, H., Liu, Y., Wu, T., Dai, Y., Wang, H., & Wang, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.819336 · Cited by 56 · see citing works
Using murine colitis models to analyze probiotics–host interactions
Martín, R., Chain, F., Miquel, S., Motta, J., Vergnolle, N., Sokol, H., & Langella, P. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux035 · Cited by 56 · see citing works
Self-citationShigemori, S., & Shimosato, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00022 · Cited by 53 · see citing works
Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health
Mani, S., Boelsterli, U. A., & Redinbo, M. R. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140007 · Cited by 48 · see citing works
Levit, R., Cortes‐Perez, N. G., de LeBlanc, A. D. M., Loiseau, J., Aucouturier, A., Langella, P., LeBlanc, J. G., & Bermúdez‐Humarán, L. G. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2110821 · Cited by 49 · see citing works
Self-citationProbiotics and Antibiotics in IBD
Sokol, H. (2014) · Digestive Diseases · doi:10.1159/000367820 · Cited by 48 · see citing works
Cheng, Y., Li, G., Smedley, C. J., Giel, M., Kitamura, S., Woehl, J. L., Bianco, G., Forli, S., Homer, J. A., Cappiello, J. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208540119 · Cited by 46 · see citing works
A red light-controlled probiotic bio-system for in-situ gut-brain axis regulation
Zhang, X., Pang, G., Sun, T., Liu, X., Pan, H., Zhang, Y., Liu, J., Chang, J. K., Wang, H., & Liu, D. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122005 · Cited by 46 · see citing works
Advances in understanding of Netherton syndrome and therapeutic implications
Petrova, E., & Hovnanian, A. (2020) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2020.1857724 · Cited by 47 · see citing works
Curciarello, R., Sobande, T. O., Jones, S., Giuffrida, P., Sabatino, A. D., Docena, G. H., MacDonald, T. T., & Kok, K. B. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s234710 · Cited by 45 · see citing works
Mkaouar, H., Akermi, N., Mariaule, V., Boudebbouze, S., Gaci, N., Szukala, F., Pons, N., Marquez, J., Gargouri, A. F., Maguin, E., et al. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0596-2 · Cited by 43 · see citing works
Proteases and small intestinal barrier function in health and disease
Giuffrida, P., Biancheri, P., & MacDonald, T. T. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000042 · Cited by 42 · see citing works
Human airway trypsin-like protease, a serine protease involved in respiratory diseases
Menou, A., Duitman, J., Flajolet, P., Sallenave, J., Mailleux, A., & Crestani, B. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00509.2016 · Cited by 42 · see citing works
Self-citationRobert, S., & Steidler, L. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s11 · Cited by 42 · see citing works
Caruso, J. A., Akli, S., Pageon, L. R., Hunt, K. K., & Keyomarsi, K. (2014) · Oncogene · doi:10.1038/onc.2014.284 · Cited by 41 · see citing works
Motta, J.-P., Rolland, C., Edir, A., Florence, A.-C., Sagnat, D., Bonnart, C., Rousset, P., Guiraud, L., Quaranta-Nicaise, M., Mas, E., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00375-w · Cited by 40 · see citing works
Self-citationDigestive Inflammation: Role of Proteolytic Dysregulation
Mariaule, V., Kriaa, A., Soussou, S., Rhimi, S., Boudaya, H., Hernandez, J. L., Maguin, E., Lesner, A., & Rhimi, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062817 · Cited by 40 · see citing works
Mizock, B. A. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.03.011 · Cited by 40 · see citing works
Tapias, N. S., Denadai‐Souza, A., Rolland-Fourcade, C., Quaranta, M., Blanpied, C., Marcellin, M., Edir, A., Rolland, C., Cirillo, C., Dietrich, G., et al. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab035 · Cited by 39 · see citing works
Self-citationBasson, A. R., Lam, M. C., & Cominelli, F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.002 · Cited by 37 · see citing works
Serine proteases at the cutting edge of IBD: Focus on gastrointestinal inflammation
Kriaa, A., Jablaoui, A., Mkaouar, H., Akermi, N., Maguin, E., & Rhimi, M. (2020) · The FASEB Journal · doi:10.1096/fj.202000031rr · Cited by 38 · see citing works
Tapias, N. S., Vergnolle, N., Denadai‐Souza, A., & Barreau, F. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa033 · Cited by 37 · see citing works
Self-citationSonogenetics-controlled synthetic designer cells for cancer therapy in tumor mouse models
Gao, T., Niu, L., Wu, X., Dai, D., Zhou, Y., Liu, M., Wu, K., Yu, Y., Guan, N., & Ye, H. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101513 · Cited by 36 · see citing works
Motta, J., Palese, S., Giorgio, C., Chapman, K., Denadai‐Souza, A., Rousset, P., Sagnat, D., Guiraud, L., Edir, A., Séguy, C., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa229 · Cited by 36 · see citing works
Self-citationBasso, L., Boué, J., Augé, C., Deraison, C., Blanpied, C., Cénac, N., Lluel, P., Vergnolle, N., & Dietrich, G. (2017) · Pain · doi:10.1097/j.pain.0000000000001103 · Cited by 35 · see citing works
Self-citationKohl, H. M., Castillo, A., & Ochoa‐Repáraz, J. (2020) · Diseases · doi:10.3390/diseases8030033 · Cited by 35 · see citing works
Sébert, M., Denadai‐Souza, A., Quaranta, M., Racaud‐Sultan, C., Chabot, S., Lluel, P., Monjotin, N., Alric, L., Portier, G., Kirzin, S., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14430 · Cited by 34 · see citing works
Self-citationMauras, A., Chain, F., Faucheux, A., Ruffié, P., Gontier, S., Ryffel, B., Butel, M., Langella, P., Bermúdez‐Humarán, L. G., & Waligora‐Dupriet, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03075 · Cited by 34 · see citing works
Self-citationThe intestinal microbiome and surgical disease
Krezalek, M. A., Skowron, K. B., Guyton, K. L., Shakhsheer, B. A., Hyoju, S. K., & Alverdy, J. C. (2016) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2016.06.001 · Cited by 32 · see citing works
Metabolic engineering of human gut microbiome: Recent developments and future perspectives
Li, P., Roos, S., Luo, H., Ji, B., & Nielsen, J. (2023) · Metabolic Engineering · doi:10.1016/j.ymben.2023.06.006 · Cited by 33 · see citing works
- Authors
- Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., Vinel, J.-P., Alric, L., Mas, E., Sallenave, J.-M., Langella, P., & Vergnolle, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, Commensal and Probiotics-Host Interactions Laboratory, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
- INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
- University of Calgary (CA)
- Microbiologie de l’alimentation au service de la santé (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Corresponding author
- Motta, Jean-Paul
- Langella, Philippe
- Vergnolle, Nathalie
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-10-31
- Volume
- 4
- Issue
- 158
- Pages
- 158ra144-158ra144
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2128549250
- Cited by
- 257
- References
- 33
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 23 · 2019: 19 · 2018: 18 · 2017: 21 · 2016: 18 · 2015: 17 · 2014: 19 · 2013: 12 · 2012: 2
- FWCI
- 24.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Keywords
- elafin, lactic acid bacteria, inflammatory bowel disease, colitis, anti-inflammatory therapy, intestinal mucosa, intestinal permeability, cytokines and chemokines, oral drug delivery, food-grade bacteria, intestinal homeostasis, protease inhibitors
- MeSH terms
- Animals, Bacteria, Colon, Humans, Inflammation, Intestinal Mucosa, Inflammatory Bowel Diseases, Mice, Elafin, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review