Donahue, Greg

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Khan, O., Giles, J. R., McDonald, S., Manne, S., Ngiow, S. F., Patel, K. P., Werner, M. T., Huang, A. C., Alexander, K. A., Wu, J. E., et al. (2019) · Nature

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 1,646

Autophagy mediates degradation of nuclear lamina

Dou, Z., Xu, C., Donahue, G., Shimi, T., Pan, J.-A., Zhu, J., Ivanov, A., Capell, B. C., Drake, A. M., Shah, P. P., et al. (2015) · Nature

Autophagy in Disease and TherapyNuclear Structure and Function

Cited by 655

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 550

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature

Memory and Neural MechanismsGenomics and Chromatin Dynamics

Cited by 514

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-awar, R., Katona, B. W., Shilatifard, A., et al. (2015) · Nature

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 493

RNA Binding to CBP Stimulates Histone Acetylation and Transcription

Bose, D. A., Donahue, G., Reinberg, D., Shiekhattar, R., Bonasio, R., & Berger, S. L. (2017) · Cell

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 426

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H., & Zaret, K. S. (2016) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 390

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Nativio, R., Lan, Y., Donahue, G., Sidoli, S., Berson, A., Srinivasan, A. R., Shcherbakova, O., Amlie-Wolf, A., Nie, J., Cui, X., et al. (2020) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 380

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

Nativio, R., Donahue, G., Berson, A., Lan, Y., Amlie-Wolf, A., Tuzer, F., Toledo, J. B., Gosai, S. J., Gregory, B. D., Torres, C., et al. (2018) · Nature Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 363

Senescent cells harbour features of the cancer epigenome

Cruickshanks, H. A., McBryan, T., Nelson, D. M., VanderKraats, N. D., Shah, P. P., van Tuyn, J., Singh Rai, T., Brock, C., Donahue, G., Dunican, D. S., et al. (2013) · Nature Cell Biology

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 358

Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers

Kim, J., Bamlet, W. R., Oberg, A. L., Chaffee, K. G., Donahue, G., Cao, X.-J., Chari, S., Garcia, B. A., Petersen, G. M., & Zaret, K. S. (2017) · Science Translational Medicine

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 269

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 233

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

Sen, P., Lan, Y., Li, C. Y., Sidoli, S., Donahue, G., Dou, Z., Frederick, B., Chen, Q., Luense, L. J., Garcia, B. A., et al. (2019) · Molecular Cell

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 164

MLL1 is essential for the senescence-associated secretory phenotype

Capell, B. C., Drake, A. M., Zhu, J., Shah, P. P., Dou, Z., Dorsey, J., Simola, D. F., Donahue, G., Sammons, M., Rai, T. S., et al. (2016) · Genes & Development

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 156

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

Crowe, E. P., Tuzer, F., Gregory, B. D., Donahue, G., Gosai, S. J., Cohen, J., Leung, Y. Y., Yetkin, E., Nativio, R., Wang, L.-S., et al. (2016) · Frontiers in Aging Neuroscience

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 110

Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice

Grindheim, J. M., Nicetto, D., Donahue, G., & Zaret, K. S. (2019) · Gastroenterology

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 35