Cited by 110Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration Mechanisms

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

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Crowe, Elizabeth P., Tuzer, Ferit, Gregory, Brian D., Donahue, Greg, Gosai, Sager J., Cohen, Justin, Leung, Yuk Y., Yetkin, Emre +7 more·2016·Frontiers in Aging Neuroscience

Abstract

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome using RNA sequencing. Senescence was induced in human fetal astrocytes by transient oxidative stress. Brain-expressed genes, including those involved in neuronal development and differentiation, were downregulated in senescent astrocytes. Remarkably, several genes indicative of astrocytic responses to injury were also downregulated, including glial fibrillary acidic protein and genes involved in the processing and presentation of antigens by major histocompatibility complex class II proteins, while pro-inflammatory genes were upregulated. Overall, our findings suggest that senescence-related changes in the function of astrocytes may impact the pathogenesis of age-related brain disorders.

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Authors
Crowe, E. P., Tuzer, F., Gregory, B. D., Donahue, G., Gosai, S. J., Cohen, J., Leung, Y. Y., Yetkin, E., Nativio, R., Wang, L.-S., Sell, C., Bonini, N. M., Berger, S. L., Johnson, F. B., & Torres, C.
Affiliations
  • Drexel University (US)
  • University of Pennsylvania (US)
Corresponding author
Torres, Claudio
Venue
Frontiers in Aging Neuroscience
Published
2016-08-31
Volume
8
Pages
208-208
ISSN
1663-4365 (ISSN-L)
OpenAlex
W2508551815
Cited by
110
References
74
Citations by year
2026: 8 · 2025: 15 · 2024: 13 · 2023: 14 · 2022: 15 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 6
FWCI
5.86
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ScholarlyCommons (University of Pennsylvania) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (RO1NS078283)
  • National Institute on Aging (R21AG046943, F30AG043307)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
astrocyte senescence, oxidative stress, transcriptome, cellular senescence, neurodegenerative diseases, aging, pro-inflammatory genes, glial fibrillary acidic protein, MHC class II antigen presentation

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