Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works

Cancer statistics, 2016

Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003 · see citing works

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works

Pancreatic Cancer

Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502 · see citing works

Phases of Biomarker Development for Early Detection of Cancer

Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686 · see citing works

ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer

Locker, G. Y., Hamilton, S. R., Harris, J. E., Jessup, J. M., Kemeny, N. E., Macdonald, J. S., Somerfield, M. R., Hayes, D. F., & Bast, R. C. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.2644 · Cited by 1,592 · see citing works

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

Wu, C., Orozco, C., Boyer, J., Leglise, M., Goodale, J., Batalov, S., Hodge, C. L., Haase, J., Janes, J. O., Huss, J. W., et al. (2009) · Genome biology · doi:10.1186/gb-2009-10-11-r130 · Cited by 1,374 · see citing works

The STARD Statement for Reporting Studies of Diagnostic Accuracy: Explanation and Elaboration

Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P., Irwig, L., Moher, D., Rennie, D., de Vet, H. C. W., & Lijmer, J. G. (2003) · Clinical Chemistry · doi:10.1373/49.1.7 · Cited by 1,124 · see citing works

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

Good, D. J., Polverini, P. J., Rastinejad, F., Beau, M. M. L., Lemons, R. S., Frazier, W. A., & Bouck, N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6624 · Cited by 1,051 · see citing works

Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer

Goonetilleke, K. S., & Siriwardena, A. K. (2006) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2006.10.004 · Cited by 880 · see citing works

Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma

Wagner, M., Redaelli, C., Lietz, M., Seiler, C., Friess, H., & Büchler, M. W. (2004) · British journal of surgery · doi:10.1002/bjs.4484 · Cited by 844 · see citing works

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

PEPE, M. S., Feng, Z., Janes, H., Bossuyt, P. M., & Potter, J. D. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn326 · Cited by 723 · see citing works

Pancreatic Cancer

Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707 · see citing works

<i>Smad4</i> is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes &amp; Development · doi:10.1101/gad.1478706 · Cited by 674 · see citing works

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

Mayers, J. R., Wu, C. H., Clish, C. B., Kraft, P., Torrence, M. E., Fiske, B. P., Yuan, C., Bao, Y., Townsend, M. K., Tworoger, S. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3686 · Cited by 652 · see citing works

Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study

Chari, S. T., Leibson, C. L., Rabe, K. G., Ransom, J., de Andrade, M., & Petersen, G. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.007 · Cited by 603 · see citing works

Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study

CHARI, S., LEIBSON, C., RABE, K., RANSOM, J., DEANDRADE, M., & PETERSEN, G. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.007 · Cited by 603 · see citing works

MicroRNA Biomarkers in Whole Blood for Detection of Pancreatic Cancer

Schultz, N. A., Dehlendorff, C., Jensen, B. V., Bjerregaard, J. K., Nielsen, K. R., Bojesen, S. E., Calatayud, D., Nielsen, S. E., Yilmaz, M., Holländer, N. H., et al. (2014) · JAMA · doi:10.1001/jama.2013.284664 · Cited by 448 · see citing works

Validation of the 6 th edition AJCC pancreatic cancer staging system

Bilimoria, K. Y., Bentrem, D. J., Ko, C. Y., Ritchey, J. D., Stewart, A. K., Winchester, D. P., & Talamonti, M. S. (2007) · Cancer · doi:10.1002/cncr.22852 · Cited by 424 · see citing works

Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer.

Tempero, M. A., Uchida, E., Takasaki, H., Burnett, D. A., Steplewski, Z., & Pour, P. M. (1987) · PubMed · Cited by 400 · see citing works

Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report

Duffy, M. J., Sturgeon, C. M., Lamerz, R., Haglund, C. H., Holubec, V. L., Klapdor, R., Nicolini, A., Topolčan, O., & Heinemann, V. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp332 · Cited by 382 · see citing works

Validation techniques for logistic regression models

Miller, M. E., Hui, S. L., & Tierney, W. M. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100805 · Cited by 322 · see citing works

Plasma Proteome Database as a resource for proteomics research: 2014 update

Nanjappa, V., Thomas, J. K., Marimuthu, A., Muthusamy, B., Radhakrishnan, A., Sharma, R., Khan, A. A., Balakrishnan, L., Sahasrabuddhe, N. A., Kumar, S., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1251 · Cited by 315 · see citing works

Progression of Pancreatic Intraductal Neoplasias to Infiltrating Adenocarcinoma of the Pancreas

Brat, D. J., Lillemoe, K. D., Yeo, C. J., Warfield, P. B., & Hruban, R. H. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199802000-00003 · Cited by 309 · see citing works

Early Detection of Sporadic Pancreatic Cancer: Summative Review

Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., Batra, S. K., Brentnall, T. A., Canto, M., Cleeter, D. F., et al. (2015) · Pancreas · doi:10.1097/mpa.0000000000000368 · Cited by 295 · see citing works

A Compendium of Potential Biomarkers of Pancreatic Cancer

Gowda, H., Kandasamy, K., Ranganathan, P., Rani, S., Ramabadran, S., Gollapudi, S., Balakrishnan, L., Dwivedi, S. B., Telikicherla, D., Selvan, L. D. N., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000046 · Cited by 287 · see citing works

Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy

Qian, W.-J., Kaleta, D. T., Petritis, B. O., Jiang, H., Liu, T., Zhang, X., Mottaz, H. M., Varnum, S. M., Camp, D. G., Huang, L., et al. (2008) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m800008-mcp200 · Cited by 208 · see citing works

On the Dangers of Cross-Validation. An Experimental Evaluation

Rao, R. B., Fung, G., & Rosales, R. (2008) · SIAM International Conference on Data Mining · doi:10.1137/1.9781611972788.54 · Cited by 207 · see citing works

Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma

Radon, T. P., Massat, N. J., Jones, R., Alrawashdeh, W., Dumartin, L., Ennis, D., Duffy, S. W., Kocher, H. M., Pereira, S. P., Guarner (posthumous), L., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2467 · Cited by 203 · see citing works

An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression

Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C., Won, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.036 · Cited by 188 · see citing works

Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism

Hawighorst, T., Velasco, P., Streit, M., Hong, Y., Kyriakides, T. R., Brown, L. F., Bornstein, P., & Detmar, M. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2631 · Cited by 149 · see citing works

Validation of Biomarkers That Complement CA19.9 in Detecting Early Pancreatic Cancer

Chan, A., Prassas, I., Dimitromanolakis, A., Brand, R. E., Serra, S., Diamandis, E. P., & Blasutig, I. M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0289 · Cited by 147 · see citing works

Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer

Capello, M., Bantis, L. E., Scélo, G., Zhao, Y., Peng, L., Dhillon, D. S., Patel, N. J., Kundnani, D. L., Wang, H., Abbruzzese, J. L., et al. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw266 · Cited by 145 · see citing works

Glycoprotein biomarker panel for pancreatic cancer discovered by quantitative proteomics analysis

Nie, S., Lo, A., Wu, J., Zhu, J., Tan, Z., Simeone, D. M., Anderson, M. A., Shedden, K. A., Ruffin, M. T., & Lubman, D. M. (2014) · Journal of Proteome Research · doi:10.1021/pr400967x · Cited by 128 · see citing works

MOPED: Model Organism Protein Expression Database

Kolker, E., Higdon, R., Haynes, W. A., Welch, D., Broomall, W., Lancet, D., Stanberry, L. I., & Kolker, N. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1177 · Cited by 112 · see citing works

Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer

Bauden, M. P., Pamart, D., Ansari, D., Herzog, M., Eccleston, M., Micallef, J., Andersson, B., & Andersson, R. E. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0139-4 · Cited by 110 · see citing works

Familial pancreatic cancer: genetic advancesPreprint

Rustgi, A. K. (2014) · Genes & Development · doi:10.1101/gad.228452.113 · Cited by 101 · see citing works

Prediagnostic Serum Biomarkers as Early Detection Tools for Pancreatic Cancer in a Large Prospective Cohort Study

Nolen, B. M., Brand, R. E., Prosser, D., Velikokhatnaya, L., Allen, P. J., Zeh, H. J., Grizzle, W. E., Lomakin, A., & Lokshin, A. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094928 · Cited by 94 · see citing works

Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer

Sun, R., Wu, J., Chen, Y., Lu, M., Zhang, S., Lu, D., & Li, Y. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-225 · Cited by 91 · see citing works

New-onset diabetes in pancreatic cancer: A study in the primary care setting

Aggarwal, G., Rabe, K. G., Petersen, G. M., & Chari, S. T. (2012) · Pancreatology · doi:10.1016/j.pan.2012.02.003 · Cited by 90 · see citing works

Stable Isotope Dilution Multidimensional Liquid Chromatography-Tandem Mass Spectrometry for Pancreatic Cancer Serum Biomarker Discovery

Yu, K. H., Barry, C. G., Austin, D., Busch, C. M., Sangar, V., Rustgi, A. K., & Blair, I. A. (2009) · Journal of Proteome Research · doi:10.1021/pr800904z · Cited by 90 · see citing works

Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus

Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., Apostolidou, S., Gentry-Maharaj, A., Fourkala, E.-O., Jacobs, I. J., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0879 · Cited by 87 · see citing works

pFind–Alioth: A novel unrestricted database search algorithm to improve the interpretation of high-resolution MS/MS data

Chi, H., He, K., Yang, B., Chen, Z., Sun, R.-X., Fan, S., Zhang, K., Liu, C., Yuan, Z., Wang, Q.-H., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.05.009 · Cited by 71 · see citing works

A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.

BORNSTEIN, P. K., Devarayalu, S., Li, P., Distèche, C. M., & Framson, P. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8636 · Cited by 67 · see citing works

Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9

Makawita, S., Dimitromanolakis, A., Soosaipillai, A. R., Soleas, I. M., Chan, A., Gallinger, S., Haun, R. S., Blasutig, I. M., & Diamandis, E. P. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-404 · Cited by 58 · see citing works

A clinical evaluation of carbohydrate antigen 19‐9 and carcinoembryonic antigen in patients with pancreatic carcinoma

Satake, K., Kanazawa, G., Kho, I., Chung, Y. S., & Umeyama, K. (1985) · Journal of Surgical Oncology · doi:10.1002/jso.2930290106 · Cited by 56 · see citing works

Familial pancreatic adenocarcinoma

Petersen, G. M. (2015) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.04.007 · Cited by 53 · see citing works

CA 19–9 in pancreatic cancer: retrospective evaluation of patients with suspicion of pancreatic cancer

Molina, V., Visa, L., Conill, C., Navarro, S., Fernández, J. M. E., Auge, J. M., Filella, X., López-Boado, M. Á., Ferrer, J., Fernández‐Cruz, L., et al. (2011) · Tumor Biology · doi:10.1007/s13277-011-0297-8 · Cited by 53 · see citing works

False Biomarker Discovery due to Reactivity of a Commercial ELISA for CUZD1 with Cancer Antigen CA125

Prassas, I., Brinc, D., Farkona, S., Leung, F., Dimitromanolakis, A., Chrystoja, C. C., Brand, R., Kulasingam, V., Blasutig, I. M., & Diamandis, E. P. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.215236 · Cited by 52 · see citing works

Nucleotide Excision Repair Pathway Polymorphisms and Pancreatic Cancer Risk: Evidence for role of MMS19L

McWilliams, R. R., Bamlet, W. R., de Andrade, M., Rider, D. N., Cunningham, J. M., & Petersen, G. M. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-1109 · Cited by 48 · see citing works

Cross-Species Antibody Microarray Interrogation Identifies a 3-Protein Panel of Plasma Biomarkers for Early Diagnosis of Pancreas Cancer

Mirus, J. E., Zhang, Y., Li, C. I., Lokshin, A. E., Prentice, R. L., Hingorani, S. R., & Lampe, P. D. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3474 · Cited by 46 · see citing works

Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer

Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., Greenhalf, W., Ghaneh, P., Neoptolemos, J. P., & Costello, E. (2009) · Journal of Proteome Research · doi:10.1021/pr800451h · Cited by 44 · see citing works

Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment

Wood, L. D., Canto, M. I., Jaffee, E. M., & Simeone, D. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.03.056 · Cited by 875 · see citing works

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium

Goggins, M., Overbeek, K. A., Brand, R., Syngal, S., Del Chiaro, M., Bartsch, D. K., Bassi, C., Carrato, A., Farrell, J., Fishman, E. K., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319352 · Cited by 659 · see citing works

Proteogenomic characterization of pancreatic ductal adenocarcinoma

Cao, L., Huang, C., Cui Zhou, D., Hu, Y., Lih, T. M., Savage, S. R., Krug, K., Clark, D. J., Schnaubelt, M., Chen, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.023 · Cited by 578 · see citing works

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Wang, B., Hu, S., Teng, Y., Chen, J., Wang, H., Xu, Y., Wang, K., Xu, J., Cheng, Y., & Gao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01889-y · Cited by 604 · see citing works

The tumour glyco-code as a novel immune checkpoint for immunotherapy

RodrÍguez, E., Schetters, S. T. T., & van Kooyk, Y. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2018.3 · Cited by 473 · see citing works

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Grossberg, A. J., Chu, L. C. H., Deig, C. R., Fishman, E. K., Hwang, W. L., Maitra, A., Marks, D. L., Mehta, A., Nabavizadeh, N., Simeone, D. M., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21626 · Cited by 491 · see citing works

Early detection of pancreatic cancer

Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482 · see citing works

Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis

Cai, J., Chen, H., Lu, M., Zhang, Y., Lu, B., You, L., Zhang, T., Dai, M., & Zhao, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.027 · Cited by 475 · see citing works

Immunotherapy and Prevention of Pancreatic Cancer

Morrison, A. H., Byrne, K. T., & Vonderheide, R. H. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.04.001 · Cited by 469 · see citing works

Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter

Luo, G., Jin, K., Deng, S., Cheng, H., Fan, Z., Gong, Y., Qian, Y., Huang, Q., Ni, Q., Liu, C., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188409 · Cited by 446 · see citing works

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

Lewis, J. M., Vyas, A. D., Qiu, Y., Messer, K. S., White, R., & Heller, M. J. (2018) · ACS Nano · doi:10.1021/acsnano.7b08199 · Cited by 283 · see citing works

Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer

Pang, Y., Wang, C., Lu, L., Wang, C., Sun, Z., & Xiao, R. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.039 · Cited by 254 · see citing works

An ultrasensitive polydopamine bi-functionalized SERS immunoassay for exosome-based diagnosis and classification of pancreatic cancer

Li, T.-D., Zhang, R., Chen, H., Huang, Z., Ye, X., Wang, H., Deng, A., & Kong, J. (2018) · Chemical Science · doi:10.1039/c8sc01611a · Cited by 223 · see citing works

Fasting blood glucose levels provide estimate of duration and progression of pancreatic cancer before diagnosis

Sharma, A., Smyrk, T. C., Levy, M. J., Topazian, M. A., & Chari, S. T. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.025 · Cited by 204 · see citing works

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., & Timpson, P. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.11.280 · Cited by 203 · see citing works

Pancreatic cancer treatment: better, but a long way to go

Torphy, R. J., Fujiwara, Y., & Schulick, R. D. (2020) · Surgery Today · doi:10.1007/s00595-020-02028-0 · Cited by 199 · see citing works

Pancreatic Cancer Surveillance and Survival of High-Risk Individuals

Blackford, A. L., Canto, M. I., Dbouk, M. H., Hruban, R. H., Katona, B. W., Chak, A., Brand, R. E., Syngal, S., Farrell, J. J., Kastrinos, F., et al. (2024) · JAMA Oncology · doi:10.1001/jamaoncol.2024.1930 · Cited by 178 · see citing works

Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review

Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158 · see citing works

Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer

Mellby, L. D., Nyberg, A. P., Johansen, J. S., Wingren, C., Nordestgaard, B. G., Bojesen, S. E., Mitchell, B. L., Sheppard, B. C., Sears, R. C., & Borrebaeck, C. A. K. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.77.6658 · Cited by 159 · see citing works

Recent Progress in Detection and Profiling of Cancer Cell‐Derived Exosomes

Xiong, H., Huang, Z., Yang, Z., Lin, Q., Yang, B., Fang, X., Liu, B., Chen, H., & Kong, J. (2021) · Small · doi:10.1002/smll.202007971 · Cited by 144 · see citing works

A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma

Yang, Z., Lariviere, M. J., Ko, J., Till, J. E., Christensen, T. E., Yee, S. S., Black, T. A., Tien, K., Lin, A. A., Shen, H., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3313 · Cited by 127 · see citing works

Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

O'Neill, R. S., & Stoita, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i26.4045 · Cited by 144 · see citing works

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer

Valle, S., Martín-Hijano, L., Alcalá, S., Alonso‐Nocelo, M., & Sáinz, B. (2018) · Cancers · doi:10.3390/cancers10020033 · Cited by 121 · see citing works

Blood biomarkers for differential diagnosis and early detection of pancreatic cancer

Al-Shaheri, F. N., Alhamdani, M. S. S., Bauer, A. S., Giese, N. A., Büchler, M. W., Hackert, T., & Hoheisel, J. D. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102193 · Cited by 115 · see citing works

Blueprint for cancer research: Critical gaps and opportunities

Elmore, L. W., Greer, S. F., Daniels, E. C., Saxe, C. C., Melner, M. H., Krawiec, G. M., Cance, W. G., & Phelps, W. C. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21652 · Cited by 121 · see citing works

Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels

Seifert, A. M., Reiche, C., Heiduk, M., Tannert, A., Meinecke, A.-C., Baier, S., von Renesse, J., Kahlert, C., Distler, M., Welsch, T., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1186-7 · Cited by 113 · see citing works

Tumor-stroma TGF-β1-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin αvβ3/CD36-mediated activation of the MAPK pathway

Nan, P., Dong, X. R., Bai, X., Lu, H., Liu, F., Sun, Y., & Zhao, X. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.025 · Cited by 111 · see citing works

Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer

Ferguson, S. W., Yang, K. S., Zelga, P. J., Liss, A. S., Carlson, J., del Castillo, C. F., & Weissleder, R. (2022) · Science Advances · doi:10.1126/sciadv.abm3453 · Cited by 110 · see citing works

THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

Zhou, X., Han, J., Zuo, A., Ba, Y., Liu, S., Xu, H., Zhang, Y., Weng, S., Zhou, Z., Liu, L., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02180-y · Cited by 110 · see citing works

Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma

Yang, H., Sun, B., Fan, L., Ma, W., Xu, K., Hall, S. R. R., Wang, Z., Schmid, R. A., Peng, R., Marti, T. M., et al. (2022) · Theranostics · doi:10.7150/thno.69590 · Cited by 107 · see citing works

Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Moreira, L., Bakir, B. S., Chatterji, P., Dantes, Z., Reichert, M., & Rustgi, A. K. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.004 · Cited by 106 · see citing works

Pancreatic cancer subtypes: a roadmap for precision medicine

Torres, C., & Grippo, P. J. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1453168 · Cited by 104 · see citing works

Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN

Yang, K. S., Ciprani, D., O’Shea, A., Liss, A. S., Yang, R., Fletcher-Mercaldo, S., Mino-Kenudson, M. A., Castillo, C. F. F.-D., & Weissleder, R. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.11.046 · Cited by 97 · see citing works

Biosensors for early diagnosis of pancreatic cancer: a review

Qian, L., Li, Q., Baryeh, K., Qiu, W., Li, K., Zhang, J., Yu, Q., Xu, D., Liu, W., Brand, R. E., et al. (2019) · Translational research · doi:10.1016/j.trsl.2019.08.002 · Cited by 92 · see citing works

miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer

Ko, J., Bhagwat, N., Black, T. A., Yee, S. S., Na, Y.-J., Fisher, S., Kim, J., Carpenter, E. L., Stanger, B. Z., & Issadore, D. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3703 · Cited by 86 · see citing works

Early Diagnosis to Improve the Poor Prognosis of Pancreatic Cancer

Kikuyama, M., Kamisawa, T., Kuruma, S., Chiba, K., Kawaguchi, S., Terada, S., & Satoh, T. (2018) · Cancers · doi:10.3390/cancers10020048 · Cited by 79 · see citing works

SERS-based immunoassay and degradation of CA19-9 mediated by gold nanowires anchored magnetic–semiconductor nanocomposites

Tian, Y., Li, X., Wang, F., Gu, C., Zhao, Z., Si, H., & Jiang, T. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124009 · Cited by 77 · see citing works

Liquid Biopsy Approach for Pancreatic Ductal Adenocarcinoma

Buscail, É., Maulat, C., Muscari, F., Chiche, L., Cordelier, P., Dabernat, S., Alix‐Panabières, C., & Buscail, L. (2019) · Cancers · doi:10.3390/cancers11060852 · Cited by 75 · see citing works

Diagnostic accuracy and added value of blood-based protein biomarkers for pancreatic cancer: a meta-analysis of aggregate and individual participant data

Boyd, L. N. C., Ali, M., Leeflang, M., Treglia, G., de Vries, R., Large, T. Y. S. L., Besselink, M. G., Giovannetti, E., van Laarhoven, H. W. M., & Geert Kazemier, M. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101747 · Cited by 70 · see citing works

Pancreatic Cancer in Chronic Pancreatitis: Pathogenesis and Diagnostic Approach

Cosquer, G. L., Maulat, C., Bournet, B., Cordelier, P., Buscail, É., & Buscail, L. (2023) · Cancers · doi:10.3390/cancers15030761 · Cited by 73 · see citing works

The Impact of Biomarkers in Pancreatic Ductal Adenocarcinoma on Diagnosis, Surveillance and Therapy

Sturm, N., Ettrich, T. J., & Perkhofer, L. (2022) · Cancers · doi:10.3390/cancers14010217 · Cited by 63 · see citing works

Organoid Models for Cancer Research

Clevers, H. C., & Tuveson, D. A. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055702 · Cited by 65 · see citing works

The Translational Status of Cancer Liquid Biopsies

Bratulić, S., Gatto, F., & Nielsen, J. (2019) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-019-00141-2 · Cited by 61 · see citing works

Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids

Smith, R. C., & Tabar, V. S. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.11.012 · Cited by 61 · see citing works

A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer

Berger, A. W., Schwerdel, D., Reinacher‐Schick, A., Uhl, W. H., Algül, H., Friess, H., Janssen, K., König, A. O., Ghadimi, M. B., Gallmeier, E., et al. (2019) · Theranostics · doi:10.7150/thno.29247 · Cited by 61 · see citing works

Peptide Nucleic Acid-Functionalized Nanochannel Biosensor for the Highly Sensitive Detection of Tumor Exosomal MicroRNA

Xiao, P., Wan, Q.-Q., Liao, T., Tu, J., Zhang, G., & Sun, Z. J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01898 · Cited by 60 · see citing works

Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer

Abe, T., Koi, C., Kohi, S., Song, K. B., Tamura, K., Macgregor‐Das, A. M., Kitaoka, N., Chuidian, M., Ford, M., Dbouk, M. H., et al. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.10.036 · Cited by 61 · see citing works

The circulating miRNAs as diagnostic and prognostic markers

Terrinoni, A., Calabrese, C., Basso, D., Aita, A., Caporali, S., Plebani, M., & Bernardini, S. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2018-0838 · Cited by 60 · see citing works

Proteomic and genomic profiling of pancreatic cancer

Ansari, D., Torén, W., Zhou, Q., Hu, D., & Andersson, R. E. (2019) · Cell Biology and Toxicology · doi:10.1007/s10565-019-09465-9 · Cited by 59 · see citing works

Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis

Kane, L. E., Mellotte, G. S., Mylod, E., O'Brien, R. M., O’Connell, F., Buckley, C. E., Arlow, J., Nguyen, K., Mockler, D., Meade, A. D., et al. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0190 · Cited by 58 · see citing works

High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9

Majumder, S., Taylor, W. R., Foote, P. H., Berger, C. K., Wu, C. W., Mahoney, D. W., Bamlet, W. R., Burger, K. N., Postier, N., de la Fuente, J., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0235 · Cited by 56 · see citing works

PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

Sun, L., Wang, Y., Wang, X., Navarro‐Corcuera, A., Ilyas, S. I., Jalan‐Sakrikar, N., Gan, C., Tu, X., Shi, Y. H., Tu, K., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110349 · Cited by 55 · see citing works

Validation of Biomarkers for Early Detection of Pancreatic Cancer

Young, M. R., Wagner, P. D., Ghosh, S., Rinaudo, J. A., Baker, S. G., Zaret, K. S., Goggins, M., & Srivastava, S. (2018) · Pancreas · doi:10.1097/mpa.0000000000000973 · Cited by 53 · see citing works

Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma

Sharma, G. G., Okada, Y., Hoff, D. D. V., & Goel, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.001 · Cited by 54 · see citing works

Current State of “Omics” Biomarkers in Pancreatic Cancer

Turanlı, B., Yildirim, E., Gülfidan, G., Arğa, K. Y., & Sinha, R. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020127 · Cited by 52 · see citing works

Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer – a comprehensive review

Reese, K.-L., Pantel, K., & Smit, D. J. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03166-w · Cited by 54 · see citing works

Clinical functional proteomics of intercellular signalling in pancreatic cancer

Huang, P., Gao, W., Fu, C., Wang, M., Li, Y., Chu, B., He, A., Li, Y., Deng, X., Zhang, Y., et al. (2024) · Nature · doi:10.1038/s41586-024-08225-y · Cited by 51 · see citing works

A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants

Earl, J., Galindo-Pumariño, C., Encinas, J., Barreto, E., Castillo, M. E., Pachón, V., Ferreiro, R., Rodríguez-Garrote, M., González-Martínez, S., y Cajal, T. R., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102675 · Cited by 50 · see citing works

The sTRA Plasma Biomarker: Blinded Validation of Improved Accuracy Over CA19-9 in Pancreatic Cancer Diagnosis

Staal, B., Liu, Y., Barnett, D., Hsueh, P., He, Z., Gao, C., Partyka, K., Hurd, M. W., Singhi, A. D., Drake, R. R., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3310 · Cited by 49 · see citing works

Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis

Mahajan, U. M., Oehrle, B., Sirtl, S., Alnatsha, A., Goni, E., Regel, I., Beyer, G., Vornhülz, M., Vielhauer, J., Chromik, A. M., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.07.047 · Cited by 48 · see citing works

Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach

Large, T. Y. S. L., Meijer, L. L., Paleckytė, R., Boyd, L. N. C., Kok, B., Wurdinger, T. D., Schelfhorst, T., Piersma, S. R., Pham, T. V., van Grieken, N. C. T., et al. (2020) · The Oncologist · doi:10.1634/theoncologist.2019-0680 · Cited by 48 · see citing works

Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis

Martínez‐Bosch, N., Cristóbal, H., Iglesias, M., Gironella, M., Barranco, L., Visa, L., Calafato, D., Jiménez-Parrado, S., Earl, J., Carrato, A., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103797 · Cited by 48 · see citing works

Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a systematic review and meta-analysis

Zhao, B., Zhao, B., & Chen, F. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002415 · Cited by 46 · see citing works

Detection of Early-Stage Pancreatic Ductal Adenocarcinoma From Blood Samples: Results of a Multiplex Biomarker Signature Validation Study

Brand, R. E., Persson, J., Bratlie, S. O., Chung, D. C., Katona, B. W., Carrato, A., Castillo, M., Earl, J., Kokkola, A., Lucas, A. L., et al. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000468 · Cited by 45 · see citing works

Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance

Okada, T., Mizukami, Y., Ono, Y., Sato, H., Hayashi, A., Kawabata, H., Koizumi, K., Masuda, S., Teshima, S., Takahashi, K., et al. (2020) · Journal of Gastroenterology · doi:10.1007/s00535-020-01724-5 · Cited by 44 · see citing works

Non-Invasive Biomarkers for Earlier Detection of Pancreatic Cancer—A Comprehensive Review

Brezgyte, G., Shah, V. M., Jach, D., & Crnogorac‐Jurcevic, T. (2021) · Cancers · doi:10.3390/cancers13112722 · Cited by 43 · see citing works

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02647-z · Cited by 43 · see citing works

Integrated targeted metabolomic and lipidomic analysis: A novel approach to classifying early cystic precursors to invasive pancreatic cancer

Gaiser, R. A., Pessia, A., Ateeb, Z., Davanian, H., Moro, C. F., Alkharaan, H., Healy, K., Ghazi, S. H., Arnelo, U., Valente, R., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46634-6 · Cited by 39 · see citing works

Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathway

Huang, J., Wang, C., Hou, Y., Tian, Y., Li, Y., Zhang, H., Zhang, L., & Li, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115455 · Cited by 39 · see citing works

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits

Rodríguez, E., Boelaars, K., Brown, K., Madunić, K., van Ee, T., Dijk, F., Verheij, J., Li, R. J. E., Schetters, S. T. T., Meijer, L. L., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02934-0 · Cited by 38 · see citing works

Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19–9 Reference Ranges

Dbouk, M. H., Abe, T., Koi, C., Ando, Y., Saba, H., Diwan, E. A., Macgregor‐Das, A. M., Blackford, A. L., Mocci, E., Beierl, K. F., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0655 · Cited by 38 · see citing works

Prognostic stratification of resected pancreatic ductal adenocarcinoma: Past, present, and future

Barhli, A., Cros, J. F., Bartholin, L., & Neuzillet, C. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.08.009 · Cited by 38 · see citing works

Thrombospondin 2/Toll-Like Receptor 4 Axis Contributes to HIF-1α-Derived Glycolysis in Colorectal Cancer

Xu, C., Gu, L., Kuerbanjiang, M., Wen, S., Xu, Q. R., & Xue, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.557730 · Cited by 37 · see citing works

Metabolic Characterization of Plasma and Cyst Fluid from Cystic Precursors to Pancreatic Cancer Patients Reveal Metabolic Signatures of Bacterial Infection

Morgell, A., Reisz, J. A., Ateeb, Z., Davanian, H., Reinsbach, S. E., Halimi, A., Gaiser, R. A., Valente, R., Arnelo, U., Chiaro, M. D., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00018 · Cited by 34 · see citing works

Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer

Peng, H., Chang, M., Hu, C.-M., Yang, H., Lee, W., & Chang, Y. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-07109-6 · Cited by 34 · see citing works

Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · BMC Cancer · doi:10.1186/s12885-022-09463-x · Cited by 34 · see citing works

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges

Root, A., Allen, P. J., Tempst, P., & Yu, K. H. (2018) · Cancers · doi:10.3390/cancers10030067 · Cited by 33 · see citing works

Proteomic biomarkers in body fluids associated with pancreatic cancer

Jiménez‐Luna, C., Torres, C., Ortíz, R., Diéguez-Castillo, C., Martínez-Galán, J., Melguizo, C., Prados, J. C., & Caba, O. (2018) · Oncotarget · doi:10.18632/oncotarget.24654 · Cited by 33 · see citing works

Serum thrombospondin-2 is a candidate diagnosis biomarker for early non-small-cell lung cancer

Jiang, Y., Yu, D., Hou, G., Jiang, J., Zhou, Q., & Xu, X. (2019) · Bioscience Reports · doi:10.1042/bsr20190476 · Cited by 32 · see citing works

Complementary Use of Carbohydrate Antigens Lewis a, Lewis b, and Sialyl-Lewis a (CA19.9 Epitope) in Gastrointestinal Cancers: Biological Rationale towards a Personalized Clinical Application

Indellicato, R., Zulueta, A., Caretti, A., & Trinchera, M. (2020) · Cancers · doi:10.3390/cancers12061509 · Cited by 32 · see citing works

Serum fibrinogen as a diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma

Chung, K. H., Lee, J.-C., Lee, J.-C., Cho, I.-K., Kim, J., Jang, W., Yoo, B. C., & Hwang, J. (2020) · Pancreatology · doi:10.1016/j.pan.2020.06.010 · Cited by 32 · see citing works

Multi‐biomarker panel prediction model for diagnosis of pancreatic cancer

Lee, D., Yoon, W., Lee, A., Han, Y., Byun, Y., Kang, J. S., Kim, H., Kwon, W., Suh, Y., Choi, Y., et al. (2021) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.986 · Cited by 32 · see citing works

Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning

Nene, N. R., Ney, A., Nazarenko, T., Blyuss, O. B., Johnston, H. E., Whitwell, H. J., Sedlak, E., Gentry‐Maharaj, A., Apostolidou, S., Costello, E., et al. (2023) · Communications Medicine · doi:10.1038/s43856-023-00237-5 · Cited by 31 · see citing works

Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis

Ding, J., Liu, Y., & Lai, Y. (2020) · PeerJ · doi:10.7717/peerj.10419 · Cited by 30 · see citing works

Identification of hub genes and analysis of prognostic values in pancreatic ductal adenocarcinoma by integrated bioinformatics methods

Lü, Y., Li, C., Chen, H., & Zhong, W. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4325-2 · Cited by 30 · see citing works

Progress of immune checkpoint therapy in the clinic (Review)

Fan, Y., Zhang, C., Jin, S., Gao, Z., Cao, J., Wang, A., Li, D., Wang, Q., Sun, X., & Bai, D. (2018) · Oncology Reports · doi:10.3892/or.2018.6819 · Cited by 30 · see citing works

Comparing distress of mouse models for liver damage

Tang, G., Seume, N., Häger, C., Kumstel, S., Abshagen, K., Bleich, A., Vollmar, B., Talbot, S. R., Zhang, X., & Zechner, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-76391-w · Cited by 30 · see citing works

A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes

Nam, H., Hong, S., Jung, K. H., Kang, S., Park, M. S., Kang, S., Kim, H. S., Mai, V.-H., Kim, J., Lee, H., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab191 · Cited by 29 · see citing works

Review of Immunohistochemistry Biomarkers in Pancreatic Cancer Diagnosis

Tuấn, L. T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.799025 · Cited by 28 · see citing works

Managing complications of chronic pancreatitis: a guide for the gastroenterologist

Capurso, G., Tacelli, M., Vanella, G., Pisani, R. P. D. L., Dell’Anna, G., Abati, M., Mele, R., Lauri, G., Panaitescu, A., Nunziata, R., et al. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2295498 · Cited by 29 · see citing works

Screening and validating the core biomarkers in patients with pancreatic ductal adenocarcinoma

Li, Y., Zhu, Y., Dai, G., Wu, D., Gao, Z., Zhang, L., & Fan, Y. (2019) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2020048 · Cited by 27 · see citing works

Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer

Hanna-Sawires, R. G., Schiphuis, J. H., Wuhrer, M., Vasen, H. F. A., van Leerdam, M. E., Bonsing, B. A., Mesker, W. E., van der Burgt, Y. E. M., & Tollenaar, R. A. �. �. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052655 · Cited by 27 · see citing works

Diagnostic Bioliquid Markers for Pancreatic Cancer: What We Have vs. What We Need

Liou, G., & Byrd, C. J. (2023) · Cancers · doi:10.3390/cancers15092446 · Cited by 25 · see citing works

Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma

Yu, J., Ploner, A., Kordes, M., Löhr, M. J., Nilsson, M., de Maturana, M. E. L., Estudillo, L., Renz, H. E., Carrato, A., Molero, X., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33464 · Cited by 24 · see citing works

Proteomics-Driven Biomarkers in Pancreatic Cancer

Ramalhete, L., Vigia, E., Araújo, R., & Marques, H. P. (2023) · Proteomes · doi:10.3390/proteomes11030024 · Cited by 24 · see citing works

THBS2/CA19-9 Detecting Pancreatic Ductal Adenocarcinoma at Diagnosis Underperforms in Prediagnostic Detection: Implications for Biomarker Advancement

Udgata, S., Takenaka, N., Bamlet, W. R., Oberg, A. L., Yee, S. S., Carpenter, E. L., Herman, D. S., Kim, J., Petersen, G. M., & Zaret, K. S. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0403 · Cited by 24 · see citing works

Advances on diagnostic biomarkers of pancreatic ductal adenocarcinoma: A systems biology perspective

Zhang, W., Wang, W., Han, X., Gao, H.-L., Li, T., Xu, S., Li, S., Xu, H., Li, H., Ye, L., et al. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.11.018 · Cited by 24 · see citing works

Survival Prediction in Pancreatic Cancer Patients with No Distant Metastasis: A Large-Scale Population-Based Estimate

Pu, N., Lv, Y., Zhao, G., Lee, W., Nuerxiati, A., Wang, D., Xu, X., Kuang, T., Wu, W., & Lou, W. (2017) · Future Oncology · doi:10.2217/fon-2017-0380 · Cited by 23 · see citing works

Early detection of pancreatic cancer: current state and future opportunities

Trikudanathan, G., Lou, E., Maitra, A., & Majumder, S. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000770 · Cited by 23 · see citing works

Screening for pancreatic cancer has the potential to save lives, but is it practical?

Mazer, B. L., Lee, J. W., Roberts, N. J., Chu, L. C. H., Lennon, A. M., Klein, A. P., Eshleman, J. R., Fishman, E. K., Canto, M. I., Goggins, M., et al. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2217354 · Cited by 23 · see citing works

A blood-based assay for diagnosis of early-stage pancreatic cancer.

Ettrich, T. J., Berger, A. W., Schwerdel, D., Reinacher‐Schick, A., Uhl, W. H., Alguel, H., Frieß, H., König, A. O., Ghadimi, M. B., Gallmeier, E., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2019.37.4_suppl.234 · Cited by 1 · see citing works

Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer

Peng, H., Chang, M., Hu, C.-M., Yang, H., Lee, W., & Chang, Y. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-07109-6 · Cited by 34 · see citing works

THBS2/CA19-9 Detecting Pancreatic Ductal Adenocarcinoma at Diagnosis Underperforms in Prediagnostic Detection: Implications for Biomarker Advancement

Udgata, S., Takenaka, N., Bamlet, W. R., Oberg, A. L., Yee, S. S., Carpenter, E. L., Herman, D. S., Kim, J., Petersen, G. M., & Zaret, K. S. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0403 · Cited by 24 · see citing works

Biomarkers for the early detection of PDAC

Ray, K. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.111 · Cited by 20 · see citing works

Eine Kombination aus blutbasierten Biomarkern zur nichtinvasiven Diagnose des resektablen duktalen Adenokarzinom des Pankreas

Ettrich, T. J., Berger, A., Schwerdel, D., Reinacher‐Schick, A., Algül, H., König, A. O., Gallmeier, E., Wille, K., Daum, S., Geißler, M., et al. (2018) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0038-1668749