Perfect, John R.

Azole antifungals: 35 years of invasive fungal infection management

Allen, D., Wilson, D., Drew, R., & Perfect, J. (2015) · Expert Review of Anti-infective Therapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 255

Phase I Evaluation of the Safety and Pharmacokinetics of Murine-Derived Anticryptococcal Antibody 18B7 in Subjects with Treated Cryptococcal Meningitis

Larsen, R. A., Pappas, P. G., Perfect, J., Aberg, J. A., Casadevall, A., Cloud, G. A., James, R., Filler, S., & Dismukes, W. E. (2005) · Antimicrobial Agents and Chemotherapy

Fungal Infections and StudiesBacterial Infections and Vaccines

Cited by 236

CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

Lionakis, M. S., Swamydas, M., Fischer, B. G., Plantinga, T. S., Johnson, M. D., Jaeger, M., Green, N. M., Masedunskas, A., Weigert, R., Mikelis, C., et al. (2013) · Journal of Clinical Investigation

Antifungal resistance and susceptibilityChemokine receptors and signaling

Cited by 230

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Smeekens, S. P., Ng, A., Kumar, V., Johnson, M. D., Plantinga, T. S., van Diemen, C., Arts, P., Verwiel, E. T. P., Gresnigt, M. S., Fransen, K., et al. (2013) · Nature Communications

Antifungal resistance and susceptibilityinterferon and immune responses

Cited by 213

Carbonic Anhydrase and CO2 Sensing during Cryptococcus neoformans Growth, Differentiation, and Virulence

Bahn, Y.-S., Cox, G. M., Perfect, J. R., & Heitman, J. (2005) · Current Biology

Fungal Infections and StudiesEnzyme function and inhibition

Cited by 205

Breakthrough invasive candidiasis in patients on micafungin.

Pfeiffer, C. D., Garcia-Effron, G., Zaas, A. K., Perfect, J. R., Perlin, D. S., & Alexander, B. D. (2010) · Journal of Clinical Microbiology

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 196

A Glucan Synthase FKS1 Homolog in Cryptococcus neoformans Is Single Copy and Encodes an Essential Function

Thompson, J. R., Douglas, C. M., Li, W., Jue, C. K., Pramanik, B., Yuan, X., Rude, T. H., Toffaletti, D. L., Perfect, J. R., & Kurtz, M. (1999) · Journal of Bacteriology

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 196

Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain

Wormley, F. L., Perfect, J. R., Steele, C., & Cox, G. M. (2007) · Infection and Immunity

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 187

Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence

Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., & Heitman, J. (2003) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 186

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

Cramer, R. A., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., & Steinbach, W. J. (2008) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 172

Synergistic Antifungal Activities of Bafilomycin A 1 , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans

Del Poeta, M., Cruz, M. C., Cardenas, M. E., Perfect, J. R., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 169

Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.

Segal, B. H., Almyroudis, N. G., Battiwalla, M., Herbrecht, R., Perfect, J. R., Walsh, T. J., & Wingard, J. R. (2007) · Clinical Infectious Diseases

Antifungal resistance and susceptibilityNeutropenia and Cancer Infections

Cited by 168

Differential Effects of Inhibiting Chitin and 1,3-β- d -Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus

Fortwendel, J. R., Juvvadi, P. R., Pinchai, N., Perfect, B. Z., Alspaugh, J. A., Perfect, J. R., & Steinbach, W. J. (2009) · Antimicrobial Agents and Chemotherapy

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 161

Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Cruz, M. C., Goldstein, A. L., Blankenship, J., Del Poeta, M., Perfect, J. R., McCusker, J. H., Bennani, Y. L., Cardenas, M. E., & Heitman, J. (2001) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 159

Quantitation of Candida CFU in Initial Positive Blood Cultures

Pfeiffer, C. D., Samsa, G. P., Schell, W. A., Reller, L. B., Perfect, J. R., & Alexander, B. D. (2011) · Journal of Clinical Microbiology

Antifungal resistance and susceptibilityBacterial Identification and Susceptibility Testing

Cited by 158

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

Desjardins, C. A., Giamberardino, C., Sykes, S. M., Yu, C.-H., Tenor, J. L., Chen, Y., Yang, T., Jones, A. M., Sun, S., Haverkamp, M. R., et al. (2017) · Genome Research

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 157

Antifungal Resistance Trends Towards the Year 2000: Implications for Therapy and New Approaches

Alexander, B. D., & Perfect, J. R. (1997) · Drugs

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 153

Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

Fortwendel, J. R., Juvvadi, P. R., Perfect, B. Z., Rogg, L. E., Perfect, J. R., & Steinbach, W. J. (2010) · Antimicrobial Agents and Chemotherapy

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 153

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Hommel, B., Mukaremera, L., Cordero, R. J. B., Coelho, C., Desjardins, C. A., Sturny-Leclère, A., Janbon, G., Perfect, J. R., Fraser, J. A., Casadevall, A., et al. (2018) · PLoS Pathogens

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 143

Role of PLB1 in Pulmonary Inflammation and Cryptococcal Eicosanoid Production

Noverr, M. C., Cox, G. M., Perfect, J. R., & Huffnagle, G. B. (2003) · Infection and Immunity

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 133

A meta-analysis of medical versus surgical therapy for Candida endocarditis

Steinbach, W. J., Perfect, J. R., Cabell, C. H., Fowler, V. G., Corey, G. R., Li, J. S., Zaas, A. K., & Benjamin, D. K. (2005) · Journal of Infection

Infective Endocarditis Diagnosis and ManagementAntifungal resistance and susceptibility

Cited by 127

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

Thammahong, A., Puttikamonkul, S., Perfect, J. R., Brennan, R. G., & Cramer, R. A. (2017) · Microbiology and Molecular Biology Reviews

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 125

Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis

Steen, B. R., Zuyderduyn, S., Toffaletti, D. L., Marra, M., Jones, S. J. M., Perfect, J. R., & Kronstad, J. (2003) · Eukaryotic Cell

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 123

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

Onyewu, C., Wormley, F. L., Perfect, J. R., & Heitman, J. (2004) · Infection and Immunity

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 121