Perfect, John R.

In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

Shaw, K. J., Schell, W. A., Covel, J., Duboc, G., Giamberardino, C., Kapoor, M., Moloney, M., Soltow, Q. A., Tenor, J. L., Toffaletti, D. L., et al. (2018) · Antimicrobial Agents and Chemotherapy

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 121

Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformans

Akhter, S., McDade, H. C., Gorlach, J. M., Heinrich, G., Cox, G. M., & Perfect, J. R. (2003) · Infection and Immunity

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 115

Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host

Price, M. S., Betancourt-Quiroz, M., Price, J. L., Toffaletti, D. L., Vora, H., Hu, G., Kronstad, J. W., & Perfect, J. R. (2011) · mBio

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 115

Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Henn, C., Nielsen, K., Heitman, J., & Perfect, J. R. (2007) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 108

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

Asai, K., Tsuchimori, N., Okonogi, K., Perfect, J. R., Gotoh, O., & Yoshida, Y. (1999) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 102

Early treatment of candidemia in adults: a review

Ostrosky-Zeichner, L., Kullberg, B. J., Bow, E. J., Hadley, S., León, C., Nucci, M., Patterson, T. F., & Perfect, J. R. (2011) · Medical Mycology

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 97

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

Liu, T.-B., Kim, J.-C., Wang, Y., Toffaletti, D. L., Eugenin, E., Perfect, J. R., Kim, K. J., & Xue, C. (2013) · PLoS Pathogens

Fungal Infections and StudiesBarrier Structure and Function Studies

Cited by 89

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

Shapiro, R. S., Zaas, A. K., Betancourt-Quiroz, M., Perfect, J. R., & Cowen, L. E. (2012) · PLoS ONE

Fungal and yeast genetics researchHeat shock proteins research

Cited by 86

Caspofungin: first approved agent in a new class of antifungals

Johnson, M. D., & Perfect, J. R. (2003) · Expert Opinion on Pharmacotherapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 85

Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion

Tenor, J. L., Oehlers, S. H., Yang, J. L., Tobin, D. M., & Perfect, J. R. (2015) · mBio

Fungal Infections and StudiesZebrafish Biomedical Research Applications

Cited by 78

Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier: Role of PLB1 in C. neoformans meningoencephalitis

Maruvada, R., Zhu, L., Pearce, D., Zheng, Y., Perfect, J., Kwon-Chung, K. J., & Kim, K. S. (2012) · Cellular Microbiology

Fungal Infections and StudiesBarrier Structure and Function Studies

Cited by 75

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance

Hope, W., Stone, N. R. H., Johnson, A., McEntee, L., Farrington, N., Santoro-Castelazo, A., Liu, X., Lucaci, A., Hughes, M., Oliver, J. D., et al. (2019) · mBio

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 70

Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus

Cramer, R. A., Stajich, J. E., Yamanaka, Y., Dietrich, F. S., Steinbach, W. J., & Perfect, J. R. (2006) · Gene

Microbial Natural Products and BiosynthesisFungal and yeast genetics research

Cited by 66

Cost of invasive fungal infections in the era of new diagnostics and expanded treatment options

Ashley, E. D., Drew, R., Johnson, M., Danna, R., Dabrowski, D., Walker, V., Prasad, M., Alexander, B., Papadopoulos, G., & Perfect, J. (2012) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 62

Predictors and outcomes of Candida bloodstream infection: Eight-year surveillance, western Saudi Arabia

Al Thaqafi, A. H. O., Farahat, F. M., Al Harbi, M. I., Al Amri, A. F. W., & Perfect, J. R. (2014) · International Journal of Infectious Diseases

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 60

Fatty Acid Synthesis Is Essential for Survival of Cryptococcus neoformans and a Potential Fungicidal Target

Chayakulkeeree, M., Rude, T. H., Toffaletti, D. L., & Perfect, J. R. (2007) · Antimicrobial Agents and Chemotherapy

Fungal Infections and StudiesCancer, Lipids, and Metabolism

Cited by 56

Blood Gene Expression Signatures Predict Invasive Candidiasis

Zaas, A. K., Aziz, H., Lucas, J., Perfect, J. R., & Ginsburg, G. S. (2010) · Science Translational Medicine

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 48

The economic costs to United States hospitals of invasive fungal infections in transplant patients

Menzin, J., Meyers, J. L., Friedman, M., Korn, J. R., Perfect, J. R., Langston, A. A., Danna, R. P., & Papadopoulos, G. (2011) · American Journal of Infection Control

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 48

Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil

Ribeiro, M. A., Paula, C. R., Perfect, J. R., & Cox, G. M. (2005) · Medical Mycology

Antifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Cited by 27