Iwama, Atsushi

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 515

Gut microbiota promotes obesity-associated liver cancer through pge2-mediated suppression of antitumor immunity.

Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery

Gut microbiota and healthHepatocellular Carcinoma Treatment and Prognosis

Cited by 478

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-aswapati, N., Radomska, H. S., Auron, P. E., Tenen, D. G., & Sun, Z. (1999) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 459

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 368

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Suda, M., Shimizu, I., Katsuumi, G., Yoshida, Y., Hayashi, Y., Ikegami, R., Matsumoto, N., Yoshida, Y., Mikawa, R., Katayama, A., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 290

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

Yamazaki, S., Iwama, A., Takayanagi, S., Morita, Y., Eto, K., Ema, H., & Nakauchi, H. (2006) · The EMBO Journal

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 270

c-Myc Is a Critical Target for C/EBPα in Granulopoiesis

Johansen, L. M., Iwama, A., Lodie, T. A., Sasaki, K., Felsher, D. W., Golub, T. R., & Tenen, D. G. (2001) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 263

Essential and Instructive Roles of GATA Factors in Eosinophil Development

Hirasawa, R., Shimizu, R., Takahashi, S., Osawa, M., Takayanagi, S., Kato, Y., Onodera, M., Minegishi, N., Yamamoto, M., Fukao, K., et al. (2002) · The Journal of Experimental Medicine

Asthma and respiratory diseasesT-cell and B-cell Immunology

Cited by 219

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., & Behre, G. (2002) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 152

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

Seki, M., Kimura, S., Isobe, T., Yoshida, K., Ueno, H., Nakajima-Takagi, Y., Wang, C., Lin, L., Kon, A., Suzuki, H., et al. (2017) · Nature Genetics

Acute Lymphoblastic Leukemia researchT-cell and Retrovirus Studies

Cited by 138

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis

Zhang, P., Iwama, A., Datta, M. W., Darlington, G. J., Link, D. C., & Tenen, D. G. (1998) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsHematopoietic Stem Cell Transplantation

Cited by 130

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Kuribayashi, W., Oshima, M., Itokawa, N., Koide, S., Nakajima-Takagi, Y., Yamashita, M., Yamazaki, S., Rahmutulla, B., Miura, F., Ito, T., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 111

Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBP

Iwama, A., Zhang, P., Darlington, G. J., McKercher, S. R., Maki, R., & Tenen, D. G. (1998) · Nucleic Acids Research

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 91

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

Rizq, O., Mimura, N., Oshima, M., Saraya, A., Koide, S., Kato, Y., Aoyama, K., Nakajima-Takagi, Y., Wang, C., Chiba, T., et al. (2017) · Clinical Cancer Research

Epigenetics and DNA MethylationMultiple Myeloma Research and Treatments

Cited by 83

Polycomb repressive complexes in hematological malignancies

Iwama, A. (2017) · Blood

Epigenetics and DNA MethylationChromatin Remodeling and Cancer

Cited by 55

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

Sera, Y., Nakata, Y., Ueda, T., Yamasaki, N., Koide, S., Kobayashi, H., Ikeda, K.-I., Kobatake, K., Iwasaki, M., Oda, H., et al. (2021) · Blood

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 42