Inter-organ cross-talk in metabolic syndrome

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023 · see citing works

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040

Ogurtsova, K., Fernandes, J. D. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D. A., Shaw, J. E., & Makaroff, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.024 · Cited by 6,977 · see citing works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works

Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.

Ogden, C., Carroll, M., Kit, B., & Flegal, K. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.40 · Cited by 4,128 · see citing works

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works

The Global Epidemic of the Metabolic Syndrome

Saklayen, M. G. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0812-z · Cited by 3,990 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885 · see citing works

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819 · see citing works

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772 · see citing works

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651 · see citing works

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

Gnanapavan, S., Kola, B., Bustin, S., Morris, D., McGee, P. J., Fairclough, P., Bhattacharya, S., Carpenter, R., Grossman, A., & Korbonits, M. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.6.8739 · Cited by 1,507 · see citing works

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

Flint, A., Raben, A., Astrup, A., & Holst, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci990 · Cited by 1,402 · see citing works

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,398 · see citing works

Prevalence of the metabolic syndrome in the United States, 2003-2012

Aguilar, M., Bhuket, T., Torres, S., Liu, B., & Wong, R. J. (2015) · JAMA · doi:10.1001/jama.2015.4260 · Cited by 1,267 · see citing works

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Goldstein, J. L., & Brown, M. S. (2015) · Cell · doi:10.1016/j.cell.2015.01.036 · Cited by 1,233 · see citing works

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,030 · see citing works

Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study

(2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00291-0 · Cited by 1,029 · see citing works

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works

The immunology of atherosclerosis

Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982 · see citing works

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 961 · see citing works

Incretin hormones: Their role in health and disease

Nauck, M. A., & Meier, J. J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13129 · Cited by 950 · see citing works

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 935 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

Hotamışlıgil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5291.1377 · Cited by 917 · see citing works

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 845 · see citing works

Interleukin-6 in acute exercise and training: what is the biological relevance?

Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817 · see citing works

Adiponectin acts in the brain to decrease body weight

Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779 · see citing works

Sex hormone-binding globulin and risk of type 2 diabetes in women and men

Ding, E. L., Song, Y., Manson, J. E., Hunter, D. J., Lee, C. C., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804381 · Cited by 726 · see citing works

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Furuhashi, M., Tuncman, G., Görgün, C. Z., Makowski, L., Atsumi, G., Vaillancourt, E., Kono, K., Babaev, V. R., Fazio, S., Linton, M. F., et al. (2007) · Nature · doi:10.1038/nature05844 · Cited by 724 · see citing works

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.-J., Mehta, H., Hevener, A. L., de Cabo, R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.009 · Cited by 715 · see citing works

Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

Makowski, L., Boord, J. B., Maeda, K., Babaev, V. R., Uysal, K. T., Morgan, M. A., Parker, R. A., Suttles, J., Fazio, S., Hotamışlıgil, G. S., et al. (2001) · Nature Medicine · doi:10.1038/89076 · Cited by 687 · see citing works

Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine

Erspamer, V., & Asero, B. (1952) · Nature · doi:10.1038/169800b0 · Cited by 674 · see citing works

Adiponectin-mediated modulation of hypertrophic signals in the heart

Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works

The Cardiovascular Biology of Glucagon-like Peptide-1

Drucker, D. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.009 · Cited by 665 · see citing works

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S., Feinstein, P. G., Mombaerts, P., & Friedman, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13914 · Cited by 657 · see citing works

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.209 · Cited by 641 · see citing works

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 625 · see citing works

Adiponectin, the past two decades

Wang, Z. V., & Scherer, P. E. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw011 · Cited by 609 · see citing works

A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7–36) Amide on Ad Libitum Energy Intake in Humans

Verdich, C., Flint, A., Gutzwiller, J., Näslund, E. B., Beglinger, C., Hellström, P. M., Long, S. J., Morgan, L., Holst, J. J., & Astrup, A. V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7877 · Cited by 600 · see citing works

Serotonin regulates pancreatic beta cell mass during pregnancy

Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586 · see citing works

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Deng, Z., Poliakov, A., Hardy, R. W., Clements, R. H., Liu, C., Liu, Y., Wang, J., Xiang, X., Zhang, S., Zhuang, X., et al. (2009) · Diabetes · doi:10.2337/db09-0216 · Cited by 573 · see citing works

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113914 · Cited by 554 · see citing works

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

Wang, G.-X., Zhao, X.-Y., Meng, Z., Kern, M., Dietrich, A., Chen, Z., Cozacov, Z., Zhou, D., Okunade, A. L., Su, X., et al. (2014) · Nature Medicine · doi:10.1038/nm.3713 · Cited by 508 · see citing works

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

Nauck, M. A., Bartels, E., Ørskov, C., Ebert, R., & Creutzfeldt, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473405 · Cited by 505 · see citing works

Suppression of body fat accumulation in myostatin-deficient mice

McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505 · see citing works

Ghrelin action in the brain controls adipocyte metabolism

Theander-Carrillo, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25811 · Cited by 465 · see citing works

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

Muoio, D. M., Dohm, G. L., Fiedorek, F. T., Tapscott, E. B., Coleman, R., & Dohn, G. L. (1997) · Diabetes · doi:10.2337/diab.46.8.1360 · Cited by 458 · see citing works

Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P., & Pedersen, B. K. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1643 · Cited by 455 · see citing works

Unraveling the Regulation of Hepatic Metabolism by Insulin

Titchenell, P. M., Lazar, M. A., & Birnbaum, M. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.003 · Cited by 434 · see citing works

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.019 · Cited by 431 · see citing works

Hormonal regulation of hepatic glucose production in health and disease

Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429 · see citing works

Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index

Shah, R. V., Murthy, V. L., Abbasi, S. A., Blankstein, R., Kwong, R. Y., Goldfine, A. B., Jerosch-Herold, M., Lima, J. A. C., Ding, J., & Allison, M. A. (2014) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2014.07.017 · Cited by 427 · see citing works

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

Cook, K. S., Min, H. Y., Johnson, D., Chaplinsky, R. J., Flier, J. S., Hunt, C. R., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299705 · Cited by 427 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans

Romeo, S., Wu, Y., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37118 · Cited by 422 · see citing works

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420 · see citing works

The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity

Makowski, L., Brittingham, K. C., Reynolds, J. M., Suttles, J., & Hotamışlıgil, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413788200 · Cited by 412 · see citing works

Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients

Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, J. J., & Ferrannini, E. (2008) · Diabetes · doi:10.2337/db07-1315 · Cited by 409 · see citing works

The metabolic actions of glucagon revisited

Habegger, K. M., Heppner, K. M., Geary, N., Bartness, T. J., DiMarchi, R., & Tschöp, M. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.187 · Cited by 406 · see citing works

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

Paulmann, N., Grohmann, M., Voigt, J.-P., Bert, B., Vowinckel, J., Bader, M., Skelin, M., Jevšek, M., Fink, H., Rupnik, M., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000229 · Cited by 404 · see citing works

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000222368.43759.a1 · Cited by 400 · see citing works

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Crewe, C., Joffin, N., Rutkowski, J. M., Kim, M., Zhang, F., Towler, D. A., Gordillo, R., & Scherer, P. E. (2018) · Cell · doi:10.1016/j.cell.2018.09.005 · Cited by 400 · see citing works

Attenuated GLP-1 secretion in obesity: cause or consequence

Ranganath, L. R., Beety, J. M., Morgan, L. M., Wright, J. W., Howland, R., & Marks, V (1996) · Gut · doi:10.1136/gut.38.6.916 · Cited by 394 · see citing works

Inflammation and Immunity in Diseases of the Arterial Tree: Players and Layers

Libby, P., & Hansson, G. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.301313 · Cited by 372 · see citing works

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Sun, Y.-X., Asnicar, M., Saha, P., Chan, L., & Smith, R. G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.004 · Cited by 368 · see citing works

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

Miao, J., Ling, A. V., Manthena, P. V., Gearing, M. E., Graham, M. J., Crooke, R. M., Croce, K. J., Esquejo, R. M., Clish, C. B., Morbid Obesity Study Group, et al. (2015) · Nature Communications · doi:10.1038/ncomms7498 · Cited by 368 · see citing works

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

Tabata, M., Kadomatsu, T., Fukuhara, S., Miyata, K., Ito, Y., Endo, M., Urano, T., Zhu, H. J., Tsukano, H., Tazume, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.003 · Cited by 363 · see citing works

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Stanford, K. I., Lynes, M. D., Takahashi, H., Baer, L. A., Arts, P. J., May, F. J., Lehnig, A. C., Middelbeek, R. J. W., Richard, J. J., So, K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.020 · Cited by 355 · see citing works

Thirty sweet years of GLUT4

Klip, A., McGraw, T. E., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008351 · Cited by 344 · see citing works

Global Health Effects of Overweight and Obesity

Gregg, E. W., & Shaw, J. E. (2017) · New England Journal of Medicine · doi:10.1056/nejme1706095 · Cited by 343 · see citing works

Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism

Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338 · see citing works

Increased secretion and expression of myostatin in skeletal muscle from extremely obese women

Hittel, D. S., Berggren, J. R., Shearer, J., Boyle, K., & Houmard, J. A. (2009) · Diabetes · doi:10.2337/db08-0943 · Cited by 324 · see citing works

Deaths: leading causes for 2010.

Heron, M. P. (2013) · PubMed · Cited by 317 · see citing works

Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Primary Hepatocytes

Gauna, C., Delhanty, P. J. D., Hofland, L. J., Janssen, J. A. M. J. L., Broglio, F., Ross, R. J. M., Ghigo, E., & van der Lely, A. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1069 · Cited by 293 · see citing works

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291 · see citing works

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

Moraes‐Vieira, P. M., Yore, M. M., Dwyer, P., Syed, I., Aryal, P., & Kahn, B. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.018 · Cited by 288 · see citing works

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 285 · see citing works

Resistin competes with lipopolysaccharide for binding to toll‐like receptor 4

Tarkowski, A., Bjersing, J. L., Shestakov, A., & Bokarewa, M. I. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00899.x · Cited by 283 · see citing works

High Salt Intake

Ma, Y., He, F. J., & MacGregor, G. A. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05948 · Cited by 281 · see citing works

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis

Simcox, J., Geoghegan, G., Maschek, J. A., Bensard, C. L., Pasquali, M., Miao, R., Lee, S., Jiang, L., Huck, I., Kershaw, E. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.006 · Cited by 277 · see citing works

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production

Cao, H., Sekiya, M., Ertunc, M. E., Burak, M. F., Mayers, J. R., White, A., Inouye, K., Rickey, L., Erçal, B., Furuhashi, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.012 · Cited by 276 · see citing works

Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart

Oshima, Y., Ouchi, N., Sato, K., Izumiya, Y., Pimentel, D. R., & Walsh, K. (2008) · Circulation · doi:10.1161/circulationaha.108.767673 · Cited by 275 · see citing works

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia · doi:10.1002/glia.21049 · Cited by 274 · see citing works

Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.

Gauna, C., Meyler, F. M., Janssen, J. A. M. J. L., Delhanty, P., Abribat, T., van Koetsveld, P. V., Hofland, L., Broglio, F., Ghigo, E., & van der Lely, A. J. (2004) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2004-0363 · Cited by 273 · see citing works

Skeletal myocytes are a source of interleukin‐6 mRNA expression and protein release during contraction: evidence of fiber type specificity

Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 273 · see citing works

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273 · see citing works

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works

Long-term adaptation to electrically induced cycle training in severe spinal cord injured individuals

Mohr, T., Andersen, J. L., Biering-Sørensen, F., Galbo, H., Bangsbo, J., Wagner, A., & Kjaer, M. (1997) · Spinal Cord · doi:10.1038/sj.sc.3100343 · Cited by 263 · see citing works

Regulation of systemic energy homeostasis by serotonin in adipose tissues

Oh, C., Namkung, J., Go, Y., Shong, K. E., Kim, K., Kim, H., Park, B.-Y., Lee, H. W., Jeon, Y. H., Shong, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7794 · Cited by 261 · see citing works

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255 · see citing works

Insulin analogues in type 1 diabetes mellitus: Getting better all the time

Mathieu, C., Gillard, P., & Benhalima, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.39 · Cited by 248 · see citing works

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

Soto, M., Cai, W., Konishi, M., & Kahn, C. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817391116 · Cited by 246 · see citing works

The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15

Nielsen, A. R., & Pedersen, B. K. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-054 · Cited by 239 · see citing works

RBP4: a controversial adipokine

Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0431 · Cited by 233 · see citing works

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3250 · Cited by 230 · see citing works

Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

Ferry, G., Tellier, E., Renouard-Try, A., Grès, S., Naime, I., Simon, M., Rodriguez, M., Boucher, J., Tack, I., Gesta, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301158200 · Cited by 230 · see citing works

Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation

Sumara, G., Sumara, O., Kim, J. K., & Karsenty, G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.014 · Cited by 225 · see citing works

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

Kong, X., Yao, T. S., Zhou, P., Kazak, L., Tenen, D. E., Lyubetskaya, A., Dawes, B. A., Tsai, L. T.-Y., Kahn, B. B., Spiegelman, B. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.004 · Cited by 223 · see citing works

Contributions of basal and postprandial hyperglycemia over a wide range of A1C levels before and after treatment intensification in type 2 diabetes

Riddle, M., Umpierrez, G., DiGenio, A., Zhou, R., & Rosenstock, J. (2011) · Diabetes Care · doi:10.2337/dc11-0632 · Cited by 219 · see citing works

Health Effects of Overweight and Obesity in 195 Countries

(2017) · New England Journal of Medicine · doi:10.1056/nejmc1710026 · Cited by 219 · see citing works

Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention

Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 215 · see citing works

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects

Feldman, B. J., Streeper, R. S., Farese, R. V., & Yamamoto, K. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607501103 · Cited by 210 · see citing works

Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

Guo, H., Jin, D., Zhang, Y., Wright, W. S., Bazuine, M., Brockman, D. A., Bernlohr, D., & Chen, X. (2010) · Diabetes · doi:10.2337/db09-1735 · Cited by 206 · see citing works

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

Leiria, L. O., Wang, C., Lynes, M. D., Yang, K., Shamsi, F., Sato, M. M., Sugimoto, S., Chen, E. Y.-S., Bussberg, V., Narain, N. R., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.001 · Cited by 205 · see citing works

Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity

Vörös, G., Maquoi, E., Demeulemeester, D., Clerx, N., Collen, D., & LIJNEN, H. R. (2005) · Endocrinology · doi:10.1210/en.2005-0532 · Cited by 203 · see citing works

Glucose Ingestion Attenuates Interleukin‐6 Release from Contracting Skeletal Muscle in Humans

Febbraio, M. A., Steensberg, A., Keller, C., Starkie, R. L., Nielsen, H. B., Krustrup, P., Ott, P., Secher, N. H., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042374 · Cited by 202 · see citing works

Exercise induces a marked increase in plasma follistatin: Evidence that follistatin is a contraction-induced hepatokine

Hansen, J., Brandt, C., Nielsen, A. R., Hojman, P., Whitham, M., Febbraio, M. A., Pedersen, B. K., & Plomgaard, P. (2011) · Endocrinology · doi:10.1210/en.2010-0868 · Cited by 200 · see citing works

Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway

QUINN, L., STRAITBODEY, L., ANDERSON, B., ARGILES, J., & HAVEL, P. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.02.005 · Cited by 199 · see citing works

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

Syed, I., Lee, J., Moraes‐Vieira, P. M., Donaldson, C. J., Sontheimer-Phelps, A., Aryal, P., Wellenstein, K., Kolar, M. J., Nelson, A. T., Siegel, D. R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.001 · Cited by 197 · see citing works

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance

Gao, S., McMillan, R. P., Zhu, Q., Lopaschuk, G. D., Hulver, M. W., & Butler, A. A. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.01.005 · Cited by 192 · see citing works

Central nervous system regulation of eating: Insights from human brain imaging

Farr, O. M., Li, C. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 191 · see citing works

Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization

Xie, Z., Wang, X., Liu, X., Du, H., Sun, C., Shao, X., Tian, J., Gu, X., Wang, H., Tian, J., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007442 · Cited by 191 · see citing works

DPP4 in Cardiometabolic Disease

Zhong, J., Maiseyeu, A., Davis, S. N., & Rajagopalan, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.305665 · Cited by 190 · see citing works

Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

Svane, M. S., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Nielsen, S., Kristiansen, V. B., Toräng, S., Wewer Albrechtsen, N. J., Rehfeld, J. F., Hartmann, B., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.121 · Cited by 185 · see citing works

Role of muscle-derived growth factors in bone formation.

Hamrick, M. W., McNeil, P. L., & Patterson, S. L. (2010) · PubMed · Cited by 181 · see citing works

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Chen, Y., Buyel, J. J., Hanssen, M. J. W., Siegel, F., Pan, R., Naumann, J., Schell, M. J., van der Lans, A. A. J. J., Schlein, C., Fröhlich, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11420 · Cited by 181 · see citing works

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control

Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00188-4 · Cited by 174 · see citing works

Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats

Yasuda, T., Masaki, T., Kakuma, T., & Yoshimatsu, H. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00789-4 · Cited by 167 · see citing works

Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?

Flier, J. S., & Maratos–Flier, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.013 · Cited by 163 · see citing works

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

Svensson, K. J., Long, J. Z., Jedrychowski, M. P., Cohen, P., Lo, J. C., Serag, S., Kır, S., Shinoda, K., Tartaglia, J. A., Rao, R. R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.008 · Cited by 160 · see citing works

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes · doi:10.2337/db13-0728 · Cited by 158 · see citing works

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158 · see citing works

Clinical relevance of the bile acid receptor TGR5 in metabolism

van Nierop, F. S., Scheltema, M. J. V., Eggink, H. M., Pols, T. W. H., Sonne, D. P., Knop, F. K., & Soeters, M. R. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30155-3 · Cited by 158 · see citing works

Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression

Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.303116 · Cited by 157 · see citing works

The renin–angiotensin system in adipose tissue and its metabolic consequences during obesity

Frigolet, M. E., Torres, N., & Tovar, A. R. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.07.002 · Cited by 156 · see citing works

Insulin Therapy for Type 2 Diabetes Mellitus

Wallia, A., & Molitch, M. E. (2014) · JAMA · doi:10.1001/jama.2014.5951 · Cited by 154 · see citing works

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00631.x · Cited by 152 · see citing works

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032938 · Cited by 152 · see citing works

Analysis of next-generation genomic data in cancer: accomplishments and challenges

Ding, L., Wendl, M. C., Koboldt, D. C., & Mardis, E. R. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq391 · Cited by 145 · see citing works

Therapeutic Potential of Targeting the Ghrelin Pathway

Colldén, G., Tschöp, M., & Müller, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040798 · Cited by 145 · see citing works

Computational reconstruction of the human skeletal muscle secretome

Bortoluzzi, S., Scannapieco, P., Cestaro, A., Danieli, G. A., & Schiaffino, S. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20803 · Cited by 136 · see citing works

Liver X receptors at the intersection of lipid metabolism and atherogenesis

Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 133 · see citing works

Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities

Guo, K., McMinn, J. E., Ludwig, T. E., Yu, Y., Yang, G., Chen, L., Loh, D., Cai, L., Chua, S. C., & Zhang, Y. (2007) · Endocrinology · doi:10.1210/en.2007-0261 · Cited by 131 · see citing works

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works

Growth differentiation factor 15 predicts advanced fibrosis in biopsy‐proven non‐alcoholic fatty liver disease

Koo, B. K., Um, S. H., Seo, D. S., Joo, S. K., Bae, J. M., Park, J. H., Chang, M. S., Kim, J. H., Lee, J., Jeong, W., et al. (2017) · Liver International · doi:10.1111/liv.13587 · Cited by 129 · see citing works

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

Kim, K. H., Kim, S., Han, D. H., Jo, Y. S., Lee, Y., & Lee, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-25098-0 · Cited by 129 · see citing works

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G., & Kersten, S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m067363 · Cited by 119 · see citing works

Hypertension as a Metabolic Disorder and the Novel Role of the Gut

Tanaka, M., & Itoh, H. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0964-5 · Cited by 118 · see citing works

Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic Fatty liver disease

Choi, H. Y., Hwang, S. Y., Lee, C. H., Hong, H. C., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.63 · Cited by 111 · see citing works

Exercise induces white adipose tissue browning across the weight spectrum in humans

Otero-Díaz, B., Rodríguez-Flores, M., Sánchez-Muñoz, V., Monraz-Preciado, F., Ordoñez-Ortega, S., Becerril-Elias, V., Baay-Guzmán, G., Obando-Monge, R., García-García, E., Palacios-González, B., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01781 · Cited by 110 · see citing works

Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development

Yan, L., Jie, H., Li, L., Chen, X.-H., Peng, H., Cao, M., & Zhang, Q. (2012) · Endocrine · doi:10.1007/s12020-012-9761-5 · Cited by 100 · see citing works

Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

Burak, M. F., Inouye, K., White, A., Lee, A., Tuncman, G., Calay, E. S., Sekiya, M., Tirosh, A., Eguchi, K., Birrane, G., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac6336 · Cited by 99 · see citing works

Upregulation of Lipocalin 2 in Adipose Tissues of Severely Obese Women: Positive Relationship With Proinflammatory Cytokines

Auguet, T., Quintero, Y., Terra, X., Martínez, S., Lucas, A., Pellitero, S., Aguilar, C., Hernández, M., Castillo, D. D., & Richart, C. (2011) · Obesity · doi:10.1038/oby.2011.61 · Cited by 97 · see citing works

Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Lee, M. J., Lee, S. A., Nam, B. Y., Park, S., Lee, S., Ryu, H. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Oh, H. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.002 · Cited by 97 · see citing works

Sodium Intake Regulates Glucose Homeostasis through the PPARδ/Adiponectin-Mediated SGLT2 Pathway

Zhao, Y., Gao, P., Sun, F., Li, Q., Chen, J., Yu, H., Li, L., Wei, X., He, H., Lu, Z., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.019 · Cited by 97 · see citing works

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Kim, T., Nason, S., Holleman, C., Pepin, M., Wilson, L., Berryhill, T. F., Wende, A. R., Steele, C., Young, M. E., Barnes, S., et al. (2018) · Diabetes · doi:10.2337/db17-1502 · Cited by 97 · see citing works

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo, H. J., & Choi, K. M. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.1.10 · Cited by 94 · see citing works

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 94 · see citing works

The role of hepassocin in the development of non-alcoholic fatty liver disease

Wu, H.-T., Lu, F.-H., Ou, H.-Y., Su, Y.-C., Hung, H.-C., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.004 · Cited by 92 · see citing works

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

Du, C., Zhang, C., Wu, W., Liang, Y., Wang, A., Wu, S., Zhao, Y., Hou, L., Ning, Q., & Luo, X. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12685 · Cited by 90 · see citing works

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

Rancoule, C., Attané, C., Grès, S., Fournel, A., Dusaulcy, R., Bertrand, C., Vinel, C., Tréguer, K., Prentki, M., Valet, P., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2891-3 · Cited by 89 · see citing works

Effect of gastric bypass surgery on the incretins

Laferrère, B. (2009) · Diabetes & Metabolism · doi:10.1016/s1262-3636(09)73458-5 · Cited by 89 · see citing works

Adipose tissue growth and regression are regulated by angiopoietin-1

Dallabrida, S. M., Zurakowski, D., Shih, S., Smith, L. E. H., Folkman, J., Moulton, K. S., & Rupnick, M. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.007 · Cited by 88 · see citing works

Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure

Li, C. Y., Cao, C.-Z., Xu, W., Cao, M., Yang, F., Dong, L., Yu, M., Zhan, Y.-Q., Gao, Y.-B., Li, W., et al. (2009) · Gut · doi:10.1136/gut.2008.171124 · Cited by 85 · see citing works

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84 · see citing works

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise

He, Z., Gao, Y., Alhadeff, A. L., Castorena, C. M., Huang, Y., Lieu, L., Afrin, S., Sun, J. M., Betley, J. N., Guo, H., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.011 · Cited by 84 · see citing works

Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes

Lee, S., Kim, W., Moon, S.-O., Sung, M. J., Kim, D. H., Kang, K. P., Jang, K. Y., Lee, S., Park, B. H., Koh, G. Y., et al. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl598 · Cited by 77 · see citing works

Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet–Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents

Cappellari, G. G., Zanetti, M., Semolic, A., Vinci, P., Ruozi, G., Falcione, A., Filigheddu, N., Guarnieri, G., Graziani, A., Giacca, M., et al. (2016) · Diabetes · doi:10.2337/db15-1019 · Cited by 77 · see citing works

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

An, Y., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M., & Scherer, P. E. (2017) · eLife · doi:10.7554/elife.24071 · Cited by 77 · see citing works

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

Barchetta, I., Cimini, F. A., Ciccarelli, G., Baroni, M. G., & Cavallo, M. G. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01052-3 · Cited by 77 · see citing works

NRG4: An Endocrine Link between Brown Adipose Tissue and Liver

Pfeifer, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.008 · Cited by 73 · see citing works

Circulating follistatin in relation to energy metabolism

Hansen, J. S., & Plomgaard, P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.002 · Cited by 62 · see citing works

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice

Pflimlin, E., Bielohuby, M., Korn, M., Breitschopf, K., Löhn, M., Wohlfart, P., Konkar, A. A., Podeschwa, M. A. L., Bärenz, F., Pfenninger, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.028 · Cited by 61 · see citing works

Insulin actions in the mesolimbic dopamine system

Liu, S., & Borgland, S. L. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113006 · Cited by 49 · see citing works

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects

Syed, I., Lee, J., Peroni, O. D., Yore, M. M., Moraes‐Vieira, P. M., Santoro, A. N., Wellenstein, K., Smith, U., McGraw, T. E., Saghatelian, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.007 · Cited by 48 · see citing works

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Wang, Y., Liu, L.-M., Li, W., Ye, W., Meng, X., Chen, F., Xiao, Q., Chen, J.-Y., & Zhou, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5637 · Cited by 46 · see citing works

Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes

Lee, M., Sorn, S. R., Lee, Y., & Kang, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010160 · Cited by 46 · see citing works

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Rahman, K., & Fisher, E. A. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00032 · Cited by 44 · see citing works

Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice

Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Miyoshi, N., Morita, A., & Miura, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40643-1 · Cited by 44 · see citing works

β-aminoisobutyric acid protects against vascular inflammation through PGC-1β-induced antioxidative properties

Sawada, M., Yamamoto, H., Ogasahara, A., Tanaka, Y., & Kihara, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.141 · Cited by 44 · see citing works

Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease

Kutlu, O., Altun, Ö., Dikker, O., Aktaş, H. Ş., Özsoy, N., Arman, Y., Çil, E. Ö., Özcan, M., Yoldemir, Ş. A., Akarsu, M., et al. (2019) · Medical Principles and Practice · doi:10.1159/000500106 · Cited by 44 · see citing works

The Gastrointestinal Tract: an Initial Organ of Metabolic Hypertension?

Zhu, Z., Xiong, S., & Liu, D. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443107 · Cited by 38 · see citing works

Effect of Ghrelin on Mortality and Cardiovascular Outcomes in Experimental Rat and Mice Models of Heart Failure: A Systematic Review and Meta-Analysis

Khatib, M. N., Shankar, A. H., Kirubakaran, R., Agho, K., Simkhada, P. P., Gaidhane, S., Saxena, D. B., Unnikrishnan, B., Gode, D., Gaidhane, A. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126697 · Cited by 35 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

A single-cell atlas of human and mouse white adipose tissue

Emont, M. P., Jacobs, C., Essene, A. L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jørgensen, A. M., Dashti, H., Stefek, A., et al. (2022) · Nature · doi:10.1038/s41586-022-04518-2 · Cited by 840 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274 · see citing works

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 297 · see citing works

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works

Macrophage functional diversity in NAFLD — more than inflammation

Barreby, E., Chen, P., & Aouadi, M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00675-6 · Cited by 246 · see citing works

MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis

Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20790-0 · Cited by 199 · see citing works

MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

Hochreuter, M. Y., Dall, M., Treebak, J. T., & Barrès, R. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101581 · Cited by 171 · see citing works

Metabolic communication during exercise

Murphy, R. M., Watt, M. J., & Febbraio, M. A. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0258-x · Cited by 158 · see citing works

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Manella, G., Sabath, E., Aviram, R., Dandavate, V., Ezagouri, S., Golik, M., Adamovich, Y., & Asher, G. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00395-7 · Cited by 151 · see citing works

Fully Automated, Semantic Segmentation of Whole-Body18F-FDG PET/CT Images Based on Data-Centric Artificial Intelligence

Sundar, L. K. S., Yu, J., Muzik, O., Kulterer, O. C., Fueger, B. J., Kifjak, D., NAKUZ, T. S., Shin, H. M., Sima, A. K., Kitzmantl, D., et al. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264063 · Cited by 149 · see citing works

Systemic Immunometabolism: Challenges and Opportunities

Lercher, A., Baazim, H., & Bergthaler, A. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.012 · Cited by 141 · see citing works

High-Risk Atherosclerosis and Metabolic Phenotype: The Roles of Ectopic Adiposity, Atherogenic Dyslipidemia, and Inflammation

Lechner, K., McKenzie, A. L., Kränkel, N., von Schacky, C., Worm, N., Nixdorff, U., Lechner, B., Scherr, J., Weingärtner, O., & Krauss, R. M. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0115 · Cited by 141 · see citing works

Immune and non-immune functions of adipose tissue leukocytes

Trim, W. V., & Lynch, L. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00635-7 · Cited by 147 · see citing works

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders

Kitamura, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043219 · Cited by 142 · see citing works

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Greco, C. M., Koronowski, K. B., Smith, J. G., Shi, J., Kunderfranco, P., Carriero, R., Chen, S., Samad, M., Welz, P.-S., Zinna, V. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi7828 · Cited by 124 · see citing works

BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

Ma, Q., Zhu, W.-Y., Lu, X., Jiang, D., Xu, F., Li, J., Zhang, L., Wu, Y., Chen, Z., Yin, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00520-6 · Cited by 119 · see citing works

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

Zhang, Z., Funcke, J., Zi, Z., Zhao, S., Straub, L. G., Zhu, Y., Zhu, Q., Crewe, C., An, Y., Chen, S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.001 · Cited by 110 · see citing works

Autophagic lysosome reformation in health and disease

Nanayakkara, R., Gurung, R., Rodgers, S. J., Eramo, M. J., Ramm, G., Mitchell, C. A., & McGrath, M. J. (2022) · Autophagy · doi:10.1080/15548627.2022.2128019 · Cited by 104 · see citing works

A gut-derived hormone regulates cholesterol metabolism

Hu, X., Chen, F., Jia, L., 隆爱军, Peng, Y. C., Li, X., Huang, J., Wei, X., Fang, X., Gao, Z., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.024 · Cited by 105 · see citing works

Gut-liver axis calibrates intestinal stem cell fitness

Kim, G., Chen, Z., Li, J., Luo, J., Castro-Martínez, F., Wiśniewski, J., Cui, K., Wang, Y., Sun, J., Ren, X., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.001 · Cited by 85 · see citing works

Diabetes and its complications: molecular mechanisms, prevention and treatment

Zhao, L., Yuan, J., Yang, Q., Ma, J., Yang, F., Zou, Y., Liu, K., & Liu, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02401-w · Cited by 80 · see citing works

The genetic architecture of biological age in nine human organ systems

Wen, J., Tian, Y., Skampardoni, I., Yang, Z., Cui, Y., Anagnostakis, F., Mamourian, E., Zhao, B., Toga, A. W., Zalesky, A., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00662-8 · Cited by 73 · see citing works

Current status and future perspectives of FGF21 analogues in clinical trials

Chui, Z. S. W., Shen, Q., & Xu, A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.001 · Cited by 68 · see citing works

Many Ways to Rome: Exercise, Cold Exposure and Diet—Do They All Affect BAT Activation and WAT Browning in the Same Manner?

Scheel, A. K., Espelage, L., & Chadt, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094759 · Cited by 64 · see citing works

The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

Lu, J., Han, S., Lv, X., Li, X., Zhang, Z., Kuang, H., Chen, Z., Lv, C.-A., Peng, W., Yang, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39710-z · Cited by 62 · see citing works

Effects of β-glucan and various thermal processing methods on the in vitro digestion of hulless barley starch

Xie, Y., Zhu, M., Liu, H., Fan, Z., Zhang, Y., Qin, X., & Xiong, L. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.129952 · Cited by 60 · see citing works

Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure

Katsumura, S., Siddiqui, N., Goldsmith, M. R., Cheah, J. H., Fujikawa, T., Minegishi, G., Yamagata, A., Yabuki, Y., Kobayashi, K., Shirouzu, M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.005 · Cited by 59 · see citing works

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Smith, J. G., Koronowski, K. B., Mortimer, T., Sato, T., Greco, C. M., Petrus, P., Verlande, A., Chen, S., Samad, M., Deyneka, E., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112588 · Cited by 56 · see citing works

Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk

van den Hoek, A. M., de Jong, J. C. B. C., Worms, N., van Nieuwkoop, A., Voskuilen, M., Menke, A. L., Lek, S., Caspers, M. P. M., Verschuren, L., & Kleemann, R. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154873 · Cited by 53 · see citing works

Systemic determinants of brain health in ageing

Smith, E. E., Biessels, G. J., Gao, V., Gottesman, R. F., Liesz, A., Parikh, N. S., & Iadecola, C. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01016-z · Cited by 54 · see citing works

Mitochondria: the gatekeepers between metabolism and immunity

Trinchese, G., Cimmino, F., Catapano, A., Cavaliere, G., & Mollica, M. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1334006 · Cited by 51 · see citing works

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Yan, Z., Yang, J. H., Wei, W.-T., Zhou, M., Mo, D.-X., Wan, X., Ma, R., Wu, M.-M., Huang, J.-H., Liu, Y.-J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48261-w · Cited by 49 · see citing works

Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

Arif, M., Klevstig, M., Benfeitas, R., Doran, S. F., Türkez, H., Uhlén, M., Clausen, M., Wikström, J., Etal, D., Zhang, C., et al. (2021) · eLife · doi:10.7554/elife.66921 · Cited by 47 · see citing works

Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation

Schwärzler, J., Mayr, L., Radlinger, B., Grabherr, F., Philipp, M., Texler, B., Grander, C., Ritsch, A., Hunjadi, M., Enrich, B., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01064-9 · Cited by 46 · see citing works

Circadian Regulation of Metabolism: Commitment to Health and Diseases

Sato, T., & Sato, S. (2023) · Endocrinology · doi:10.1210/endocr/bqad086 · Cited by 50 · see citing works

Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia

Lemecha, M., Chalise, J. P., Takamuku, Y., Zhang, G., Yamakawa, T., Larson, G. P., & Itakura, K. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101612 · Cited by 44 · see citing works

Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Xie, H., Yepuri, N., Meng, Q., Dhawan, R., Leech, C. A., Chepurny, O., Holz, G. G., & Cooney, R. (2020) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-020-09584-3 · Cited by 37 · see citing works

Biochemical and immunological changes in obesity

Barakat, B., & de Almeida, M. E. F. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108951 · Cited by 42 · see citing works

New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation

Aguilar, M., Rose, R. A., Takawale, A. R., Nattel, S., & Reilly, S. N. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab080 · Cited by 42 · see citing works

Targeting cancer cachexia: Molecular mechanisms and clinical study

Wang, Y., An, Z.-Y., Lin, D., & Jin, W. (2022) · MedComm · doi:10.1002/mco2.164 · Cited by 39 · see citing works

Inter-organ communication is a critical machinery to regulate metabolism and aging

Tokizane, K., & Imai, S. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.013 · Cited by 42 · see citing works

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

González-Franquesa, A., Gama-Pérez, P., Kulis, M., Szczepanowska, K., Dahdah, N., Moreno-Gomez, S., Latorre-Pellicer, A., Fernandez‐Ruiz, R., Aguilar‐Mogas, A., Hoffman, A., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102353 · Cited by 39 · see citing works

Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet‐Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis

Win, S., Min, R. W. M., Zhang, J., Kanel, G. C., Wanken, B., Chen, Y., Li, M., Wang, Y., Suzuki, A., Aung, F. W. M., et al. (2021) · Hepatology · doi:10.1002/hep.32083 · Cited by 38 · see citing works

Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention

Than, N. G., Romero, R. J., Györffy, D., Posta, M., Bhatti, G., Done, B., Chaemsaithong, P., Jung, E., Suksai, M., Gotsch, F., et al. (2022) · Journal of Perinatal Medicine · doi:10.1515/jpm-2022-0433 · Cited by 36 · see citing works

Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review

Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 36 · see citing works

Brain–body communication in metabolic control

Furlan, A., & Petrus, P. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.014 · Cited by 34 · see citing works

Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

Griffin, J. D., Buxton, J. M., Culver, J. A., Barnes, R., Jordan, E. A., White, A. R., Flaherty, S. E., Bernardo, B. L., Ross, T. T., Bence, K. K., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101830 · Cited by 38 · see citing works

In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome

Juguilon, C., Khosravi, R., Radisic, M., & Wu, J. C. (2025) · Circulation Research · doi:10.1161/circresaha.125.325497 · Cited by 39 · see citing works

Metabolic syndrome and the plasma proteome: from association to causation

Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Köenig, W., Sinner, M. F., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01299-2 · Cited by 34 · see citing works

Who would have thought—Myokines two decades on

Febbraio, M. A., & Pedersen, B. K. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00408-7 · Cited by 34 · see citing works

Activating transcription factor 3, glucolipid metabolism, and metabolic diseases

Hu, S., Zhao, X., Li, R., Hu, C., Wu, H., Li, J., Zhang, Y., & Xu, Y. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac067 · Cited by 33 · see citing works

Organ Crosstalk and the Modulation of Insulin Signaling

Romero, A., & Eckel, J. (2021) · Cells · doi:10.3390/cells10082082 · Cited by 33 · see citing works

Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver

López-Bermudo, L., Luque‐Sierra, A., Maya‐Miles, D., Gallego‐Durán, R., Ampuero, J., Romero‐Gómez, M., Berná, G., & Martı́n, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.892672 · Cited by 32 · see citing works

Dysregulated systemic metabolism in a Down syndrome mouse model

Sarver, D. C., Xu, C., Vélez, L. M., Aja, S. M., Jaffe, A. E., Seldin, M. M., Reeves, R. H., & Wong, G. W. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101666 · Cited by 31 · see citing works

Laminins in metabolic tissues

GODDI, A. A., Schroedl, L. M., Brey, E. M., & Cohen, R. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154775 · Cited by 30 · see citing works

Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess

Luk, C., Haywood, N. J., Bridge, K., & Kearney, M. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882923 · Cited by 29 · see citing works

Cellular Mechanisms Mediating Exercise-Induced Protection against Cardiotoxic Anthracycline Cancer Therapy

Dozic, S., Howden, E. J., Bell, J. R., Mellor, K. M., Delbridge, L. M. D., & Weeks, K. L. (2023) · Cells · doi:10.3390/cells12091312 · Cited by 29 · see citing works

Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos

Lee, C. J. M., Kosyakovsky, L. B., Khan, M. S., Wu, F., Chen, G., Hill, J. A., Ho, J. E., Foo, R., & Zannad, F. M. (2025) · Circulation Research · doi:10.1161/circresaha.125.325602 · Cited by 31 · see citing works

Inter‐Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA

Ramos‐Romero, S., Léniz, A., Martínez‐Maqueda, D., Amézqueta, S., Fernández‐Quintela, A., Hereu, M., Torres, J. L., Portillo, M. P., & Pérez‐Jiménez, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000113 · Cited by 29 · see citing works

Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers

Kasper, P., Breuer, S., Hoffmann, T., Vohlen, C., Janoschek, R., Schmitz, L., Appel, S., Fink, G., Hünseler, C., Quaas, A., et al. (2021) · Cells · doi:10.3390/cells10051247 · Cited by 28 · see citing works

Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila

Zhao, Y., Khallaf, M. A., Johansson, E., Dzaki, N., Bhat, S., Alfredsson, J., Duan, J., Hansson, B. S., Knaden, M., & Alenius, M. (2022) · Nature Communications · doi:10.1038/s41467-022-35527-4 · Cited by 28 · see citing works

Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis

Sekita, A., Kawasaki, H., Fukushima‐Nomura, A., Yashiro, K., Tanese, K., Toshima, S., Ashizaki, K., Miyai, T., Yazaki, J., Kobayashi, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41857-8 · Cited by 29 · see citing works

SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway

Bian, C., Zhang, H., Gao, J., Wang, Y., Li, J., Guo, D., Wang, W., Song, Y., Weng, Y., & Ren, H. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00715-1 · Cited by 25 · see citing works

Multi‐Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk

Kim, J. J., Bae, M., & Cho, D. (2024) · Small Science · doi:10.1002/smsc.202400314 · Cited by 24 · see citing works

Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin

Wolff, C. A., Lawrence, M. M., Porter, H. L., Zhang, Q., Reid, J. J., Laurin, J. L., Musci, R. V., Linden, M. A., Peelor, F. F., Wren, J. D., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00243-8 · Cited by 24 · see citing works

Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention

Than, N. G., Romero, R. J., Posta, M., Györffy, D., Szalai, G., Rossi, S. W., Szilágyi, A., Hupuczi, P., Nagy, S., Török, O., et al. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.104172 · Cited by 22 · see citing works

Metabokines in the regulation of systemic energy metabolism

MacCannell, A. D. V., & Roberts, L. D. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102286 · Cited by 23 · see citing works

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

van der Meer, D., Gurholt, T. P., Sønderby, I. E., Shadrin, A. A., Hindley, G., Rahman, Z., de Lange, A. G., Frei, O., Leinhard, O. D., Linge, J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04237-4 · Cited by 25 · see citing works

A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity

Kim, H., Song, Z., Zhang, R., Davies, B. S. J., & Zhang, K. (2023) · Science Signaling · doi:10.1126/scisignal.add6702 · Cited by 23 · see citing works

Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation

Ozturk, I., Elbe, H., Biçer, Y., Karayakali, M., Önal, M. Ö., & Altınöz, E. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113658 · Cited by 23 · see citing works

Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

Hu, X., Sun, M., Chen, Q., Zhao, Y., Liang, N., Wang, S., Yin, P., Yang, Y., Lam, S. M., Zhang, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43402-z · Cited by 24 · see citing works

Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

Zhang, Y., & Fang, X.-M. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6655335 · Cited by 23 · see citing works

Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Adzavon, Y. M., Xie, F., Yang, Y., Jiang, X., Zhang, X., He, J., Zhao, P., Liu, M., Ma, S., & Ma, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-07710-6 · Cited by 21 · see citing works

Molecular network strategy in multi-omics and mass spectrometry imaging

Zhao, C., Dong, J., Deng, L., Tan, Y., Jiang, W., & Cai, Z. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102199 · Cited by 22 · see citing works

Association among inflammaging, body composition, physical activity, and physical function tests in physically active women

Santos, C. A. F., Amirato, G. R., Paixão, V., Almeida, E. B., do Amaral, J. B., Monteiro, F. R., Roseira, T., Juliano, Y., Novo, N. F., Rossi, M. N., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1206989 · Cited by 21 · see citing works

The Pan-liver Network Theory

Zhang, Y., & Fang, X.-M. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-22-00131 · Cited by 22 · see citing works

Management of patients with the cardio renal liver metabolic syndrome: The need for a multidisciplinary approach in research, education and practice

Angelidi, A. M., Sanoudou, D., Hill, M. A., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155997 · Cited by 20 · see citing works

Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

Trapečar, M. (2021) · FEBS Letters · doi:10.1002/1873-3468.14260 · Cited by 21 · see citing works

Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity

Ramms, B., Pollow, D. P., Zhu, H., Nora, C., Harrington, A. R., Omar, I., Gordts, P. L. S. M., Wortham, M., & Sander, M. (2022) · Diabetes · doi:10.2337/db21-1131 · Cited by 20 · see citing works

Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice

Gonzalez, P., Santos, A. D., Darnaud, M., Moniaux, N., Rapoud, D., Lacoste, C., Nguyen, T.-S., Moullé, V. S. F., Deshayes, A., Amouyal, G., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04616-5 · Cited by 21 · see citing works

A transcriptomic and proteomic atlas of obesity and type 2 diabetes in cynomolgus monkeys

Zhang, X., Hu, L. G., Lei, Y., Stolina, M., Homann, O. R., Wang, S., Véniant, M. M., & Hsu, Y. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112952 · Cited by 20 · see citing works

The Role of Extracellular Vesicles in Metabolic Diseases

González-Blanco, C., Iglesias-Fortes, S., Lockwood, Á. C., Figaredo, C., Vitulli, D., & Guillén, C. (2024) · Biomedicines · doi:10.3390/biomedicines12050992 · Cited by 20 · see citing works

Intercellular communication is crucial in the regulation of healthy aging via exosomes

Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 23 · see citing works

Organoids in concert: engineering in vitro models toward enhanced fidelity

Chen, Z., Sugimura, R., Zhang, Y. S., Ruan, C., & Wen, C. (2024) · Aggregate · doi:10.1002/agt2.478 · Cited by 20 · see citing works

Remodeling p38 signaling in muscle controls locomotor activity via IL-15

Folgueira, C., Herrera‐Melle, L., López, J. A., Galván-Álvarez, V., Martín-Rincón, M., Cuartero, M. I., García‐Culebras, A., Dumesic, P. A., Rodríguez, E., Leiva‐Vega, L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn5993 · Cited by 18 · see citing works

Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids

Handelman, S. K., Puentes, Y., Kuppa, A., Chen, Y., Du, X., Feitosa, M. F., Palmer, N. D., & Speliotes, E. K. (2022) · Hepatology Communications · doi:10.1002/hep4.2066 · Cited by 19 · see citing works

A multi-omic landscape of steatosis-to-NASH progression

Xiang, L., Li, X., Luo, Y., Zhou, B., Liu, Y., Li, Y., Wu, D., Jia, L., Zhu, P., Zheng, M., et al. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac034 · Cited by 18 · see citing works

Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15

He, F., Jiang, H., Peng, C., Wang, T., Xiao, R., Chen, M., Song, N., Du, Z., Wang, H., Ding, X., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.011 · Cited by 18 · see citing works

Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [ 18 F]FDG‐PET/CT imaging: A multi‐centre study

Ferrara, D., Abenavoli, E. M., Beyer, T., Grünert, S., Hacker, M., Hesse, S., Hofmann, L., Pusitz, S., Rullmann, M., Sabri, O., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13571 · Cited by 18 · see citing works

Extracellular Vesicles in Metabolism and Metabolic Diseases

Marzan, A. L., Nedeva, C., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_15 · Cited by 18 · see citing works

Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism

Jatana, S., Abbadi, A., West, G. A., Ponti, A. K., Neto, M. B. B., Smith, J. L., Marino‐Melendez, A., Willard, B. B., Nagy, L. E., & de la Motte, C. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.08.007 · Cited by 17 · see citing works

Towards harnessing the value of organokine crosstalk to predict the risk for cardiovascular disease in non-alcoholic fatty liver disease

Baars, T., Gieseler, R. K. H., Patsalis, P., & Canbay, A. E. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155179 · Cited by 16 · see citing works

Hepatic interoception in health and disease

Berthoud, H., Münzberg, H., Morrison, C. D., & Neuhuber, W. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103174 · Cited by 17 · see citing works

A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss

Liu, C., Khan, A., Seban, N., Littlejohn, N. K., Shah, A., & Srinivasan, S. (2024) · Nature Communications · doi:10.1038/s41467-024-51077-3 · Cited by 16 · see citing works

Exosomal miRNA combined with anti-inflammatory hyaluronic acid-based 3D bioprinted hepatic patch promotes metabolic reprogramming in NAFLD-mediated fibrosis

Saha, T., Mehrotra, S., Gupta, P., & Kumar, A. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123140 · Cited by 16 · see citing works

GLP-1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents, and hypothalamus for controlling glycemia and feeding

Yada, T., Dezaki, K., & Iwasaki, Y. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00168.2025 · Cited by 16 · see citing works

The Effect of Exercise Intensity and Volume on Metabolic Phenotype in Patients with Metabolic Syndrome: A Randomized Controlled Trial

von Korn, P., Keating, S. E., Mueller, S., Haller, B., Kränkel, N., Dinges, S. M.-T., Duvinage, A., Scherr, J., Wisløff, U., Tjønna, A. E., et al. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0105 · Cited by 17 · see citing works

Xenogeneic support for the recovery of human donor organs

O’Neill, J. D., Guenthart, B. A., Hozain, A. E., & Bacchetta, M. D. (2021) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2021.07.055 · Cited by 16 · see citing works

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178 · see citing works

Inter-organ communication involved in metabolic regulation at the whole-body level

Katagiri, H. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00306-1 · Cited by 24 · see citing works

Roles of the interorgan neuronal network in the development of metabolic syndrome

Uno, K. (2016) · Diabetology International · doi:10.1007/s13340-016-0277-8 · Cited by 4 · see citing works

Lipid metabolites as metabolic messengers in inter-organ communication

Liu, S., Alexander, R., & Lee, C. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.05.002 · Cited by 54 · see citing works

Editorial: Intra and inter organ cross-talk and cellular communication

Denechaud, P., & Rabhi, N. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1209436 · Cited by 4 · see citing works