Lu, Kun Ping

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

Lu, P.-J., Wulf, G., Zhou, X. Z., Davies, P., & Lu, K. P. (1999) · Nature

Alzheimer's disease research and treatmentsSignaling Pathways in Disease

Cited by 721

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

Lu, K. P., & Zhou, X. Z. (2007) · Nature Reviews Molecular Cell Biology

Signaling Pathways in DiseaseProtein Kinase Regulation and GTPase Signaling

Cited by 682

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Pastorino, L., Sun, A., Lu, P.-J., Zhou, X. Z., Balastik, M., Finn, G., Wulf, G., Lim, J., Li, S.-H., Li, X., et al. (2006) · Nature

Alzheimer's disease research and treatmentsSignaling Pathways in Disease

Cited by 487

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

Kondo, A., Shahpasand, K., Mannix, R., Qiu, J., Moncaster, J., Chen, C.-H., Yao, Y., Lin, Y.-M., Driver, J. A., Sun, Y., et al. (2015) · Nature

Alzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 445

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

Driver, J. A., Beiser, A., Au, R., Kreger, B. E., Splansky, G. L., Kurth, T., Kiel, D. P., Lu, K. P., Seshadri, S., & Wolf, P. A. (2012) · BMJ

Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

Cited by 425

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Wei, S., Kozono, S., Kats, L., Nechama, M., Li, W., Guarnerio, J., Luo, M., You, M.-H., Yao, Y., Kondo, A., et al. (2015) · Nature Medicine

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

Cited by 272

Critical Role of WW Domain Phosphorylation in Regulating Phosphoserine Binding Activity and Pin1 Function

Lu, P.-J., Zhou, X. Z., Liou, Y.-C., Noel, J. P., & Lu, K. P. (2002) · Journal of Biological Chemistry

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 244

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

Lee, T. H., Chen, C.-H., Suizu, F., Huang, P., Schiene-Fischer, C., Daum, S., Zhang, Y. J., Goate, A., Chen, R.-H., Zhou, X. Z., et al. (2011) · Molecular Cell

Signaling Pathways in DiseaseProtein Kinase Regulation and GTPase Signaling

Cited by 183

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Kozono, S., Lin, Y.-M., Seo, H.-S., Pinch, B., Lian, X., Qiu, C., Herbert, M. K., Chen, C.-H., Tan, L., Gao, Z. J., et al. (2018) · Nature Communications

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

Cited by 168

Association of cancer and Alzheimer's disease risk in a national cohort of veterans

Frain, L., Swanson, D., Cho, K., Gagnon, D., Lu, K. P., Betensky, R. A., & Driver, J. (2017) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

Cited by 115

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

Hilton, B. A., Li, Z., Musich, P. R., Wang, H., Cartwright, B. M., Serrano, M., Zhou, X. Z., Lu, K. P., & Zou, Y. (2015) · Molecular Cell

Cell death mechanisms and regulationSignaling Pathways in Disease

Cited by 95

Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis–trans isomerase Pin1

Liu, W., Youn, H.-D., Zhou, X. Z., Lu, K. P., & Liu, J. O. (2001) · FEBS Letters

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 52