Tackenberg, Christian

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

Birnbaum, J. H., Wanner, D., Gietl, A. F., Saake, A., Kündig, T. M., Hock, C., Nitsch, R. M., & Tackenberg, C. (2018) · Stem Cell Research

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 135

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

Tackenberg, C., Grinschgl, S., Trutzel, A., Santuccione, A. C., Frey, M. C., Konietzko, U., Grimm, J., Brandt, R., & Nitsch, R. M. (2013) · Cell Death & Disease

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 130

Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau

Tackenberg, C., & Brandt, R. (2009) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 127

Thin, Stubby or Mushroom: Spine Pathology in Alzheimers Disease

Tackenberg, C., Ghori, A., & Brandt, R. (2009) · Current Alzheimer Research

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 112

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 105

Isoform- and cell-state-specific lipidation of ApoE in astrocytes

Lindner, K., Beckenbauer, K., van Ek, L. C., Titeca, K., de Leeuw, S. M., Awwad, K., Hanke, F., Korepanova, A. V., Rybin, V., van der Kam, E. L., et al. (2022) · Cell Reports

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 84

Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices

Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., & Brandt, R. (2006) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 81

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation

Tackenberg, C., & Nitsch, R. M. (2019) · Molecular Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 56

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

de Leeuw, S., & Tackenberg, C. (2019) · Translational Neurodegeneration

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 31

Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer's disease

Budny, V., Ruminot, I., Wybitul, M., Treyer, V., Barros, L. F., & Tackenberg, C. (2025) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 25

APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons

Budny, V., Knöpfli, Y., Meier, D., Zürcher, K., Bodenmann, C., Peter, S. L., Müller, T., Tardy, M., Cortijo, C., & Tackenberg, C. (2024) · Cells

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 15

APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons

Budny, V., Knöpfli, Y., Meier, D., Zürcher, K., Bodenmann, C., Peter, S. L., Müller, T., Tardy, M., Cortijo, C., & Tackenberg, C. (2024) · Cells

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 14

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 14

APOE genotype-dependent differences in human astrocytic energy metabolism

Budny, V., Bodenmann, C., Zürcher, K. J., Krüger, M., de Leeuw, S. M., Weber, R. Z., Rust, R., Ravotto, L., Ruminot, I., Barros, L. F., et al. (2025) · Frontiers in Cellular Neuroscience

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 6