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Cited by 31Pluripotent Stem Cells ResearchAlzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

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de Leeuw, Sherida, Tackenberg, Christian·2019·Translational Neurodegeneration
DOI 10.1186/s40035-019-0161-0PMC PMC6624934
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Abstract

BACKGROUND: Since the discovery of the induced pluripotent stem cell (iPSC) technique more than a decade ago, extensive progress has been made to develop clinically relevant cell culture systems. Alzheimer's disease (AD) is the most common neurodegenerative disease, accounting for approximately two thirds of all cases of dementia. The massively increasing number of affected individuals explains the major interest of research in this disease as well as the strong need for better understanding of disease mechanisms. MAIN BODY: IPSC-derived neural cells have been widely used to recapitulating key aspects of AD. In this Review we highlight the progress made in studying AD pathophysiology and address the currently available techniques, such as specific differentiation techniques for AD-relevant cell types as well as 2D and 3D cultures. Finally, we critically discuss the key challenges and future directions of this field and how some of the major limitations of the iPSC technique may be overcome. CONCLUSION: Stem cell-based disease models have the potential to induce a paradigm shift in biomedical research. In particular, the combination of the iPSC technology with recent advances in gene editing or 3D cell cultures represents a breakthrough for in vitro disease modeling and provides a platform for a better understanding of disease mechanisms in human cells and the discovery of novel therapeutics.

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  • Cellular functions or expression of several disease-relevant proteins, including APOE, may strongly differ between rodent and human neuronal cells.

    “as cellular functions or expression of several disease-relevant proteins, including APOE, may strongly differ between rodent and human neuronal cells [11].”

    From APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons (2024) · cites this paper as [11]

    The Alzheimer’s disease pathophysiology section says human glia differ structurally and functionally from murine glia, and its APOE subsection discusses ApoE expression and effects in neural models (page not available in our copy). It does not say that APOE or other disease-relevant proteins differ in function or expression between rodent and human neuronal cells; the species comparison concerns glia, not neurons. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • APOE isoforms differentially affect astrocyte function.

    “APOE isoforms differentially affect astrocyte function (de Leeuw and Tackenberg, 2019).”

    From APOE genotype-dependent differences in human astrocytic energy metabolism (2025) · cites this paper as de Leeuw and Tackenberg, 2019

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Cited by

Sorted by citations

Authors
de Leeuw, S., & Tackenberg, C.
Affiliations
University of Zurich (CH)
Corresponding author
Tackenberg, Christian
ORCID
Tackenberg, Christian
Venue
Translational Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2019-07-12
Volume
8
Issue
1
Pages
21-21
ISSN
2047-9158 (ISSN-L)
DOI
10.1186/s40035-019-0161-0
PMC
PMC6624934
OpenAlex
W2960258369
Cited by
31
References
31
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 1
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Neurodegeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection (cc-by)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Neuroscience Center Zurich (-)
  • Betty and David Koetser Foundation for Brain Research (-)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
Alzheimer's disease, induced pluripotent stem cells, iPSC-derived neural cells, disease modeling, iPSC differentiation, 3D cell culture, 2D cell culture, genome editing, neurodegeneration, therapeutic discovery

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