Klann, Eric

mTOR signaling: At the crossroads of plasticity, memory and disease

Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences

PI3K/AKT/mTOR signaling in cancerGenetics and Neurodevelopmental Disorders

Cited by 1,128

Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories

Monfils, M.-H., Cowansage, K. K., Klann, E., & LeDoux, J. E. (2009) · Science

Memory and Neural MechanismsMemory Processes and Influences

Cited by 960

Translational control of long-lasting synaptic plasticity and memory

Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 944

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling

Redox biology and oxidative stressNeuroscience and Neuropharmacology Research

Cited by 635

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersPI3K/AKT/mTOR signaling in cancer

Cited by 557

Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures

Stanciu, M., Wang, Y., Kentor, R., Burke, N., Watkins, S., Kress, G., Reynolds, I., Klann, E., Angiolieri, M. R., Johnson, J. W., et al. (2000) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingRedox biology and oxidative stress

Cited by 539

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression

Hou, L., & Klann, E. (2004) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 527

The translation of translational control by FMRP: therapeutic targets for FXS

Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 491

Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression

Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 469

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 316

CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 296

Dysregulation and restoration of translational homeostasis in fragile X syndrome

Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 275

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

Ma, T., Hoeffer, C. A., Capetillo-Zarate, E., Yu, F., Wong, H., Lin, M. T., Tampellini, D., Klann, E., Blitzer, R. D., & Gouras, G. K. (2010) · PLoS ONE

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 262

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

Massaad, C. A., Washington, T. M., Pautler, R. G., & Klann, E. (2009) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 223

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., & Tassone, F. (2012) · Genes, Brain and Behavior

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 198

Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β

Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P., & Klann, E. (2014) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 191

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 168

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

Huber, K. M., Klann, E., Costa-Mattioli, M., & Zukin, R. S. (2015) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 167

Altered Hippocampal Synaptic Plasticity in the Fmr1 Gene Family Knockout Mouse Models

Zhang, J., Hou, L., Klann, E., & Nelson, D. L. (2009) · Journal of Neurophysiology

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 126

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

Santini, E., & Klann, E. (2014) · Science Signaling

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 118

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 117

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

Hoeffer, C. A., Cowansage, K. K., Arnold, E. C., Banko, J. L., Moerke, N. J., Rodriguez, R., Schmidt, E. K., Klosi, E., Chorev, M., Lloyd, R. E., et al. (2011) · Proceedings of the National Academy of Sciences

Memory and Neural MechanismsMemory Processes and Influences

Cited by 114

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Siarey, R. J., Kline‐Burgess, A., Cho, M., Balbo, A., Best, T. K., Harashima, C., Klann, E., & Galdzicki, Z. (2006) · Journal of Neurochemistry

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 86

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex

Chévere-Torres, I., Kaphzan, H., Bhattacharya, A., Kang, A., Maki, J. M., Gambello, M. J., Arbiser, J. L., Santini, E., & Klann, E. (2012) · Neurobiology of Disease

Tuberous Sclerosis Complex ResearchGenetics and Neurodevelopmental Disorders

Cited by 83