Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
Open accessAbstract
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream of the translation machinery. We sought to perturb p70 ribosomal S6 kinase 1 (S6K1), a key translation initiation and elongation regulator, in FXS model mice. We found that genetic reduction of S6K1 prevented elevated phosphorylation of translational control molecules, exaggerated protein synthesis, enhanced mGluR-dependent long-term depression (LTD), weight gain, and macro-orchidism in FXS model mice. In addition, S6K1 deletion prevented immature dendritic spine morphology and multiple behavioral phenotypes, including social interaction deficits, impaired novel object recognition, and behavioral inflexibility. Our results support the model that dysregulated protein synthesis is the key causal factor in FXS and that restoration of normal translation can stabilize peripheral and neurological function in FXS.
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Many classic behavioural phenotypes used as preclinical outcome measures are inconsistently observed in Fmr1-knockout mice.
“many of the other classic behavioural phenotypes used as outcome measures in preclinical studies are inconsistently observed in Fmr1-KO mice (such as open field, rotarod, elevated plus-maze, marble burying, self-grooming and most social paradigms).”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [49]
Rescue of these behavioural phenotypes has been difficult to consolidate and to use as a guide for clinical studies.
“As a result, the rescue of these behavioural phenotypes has been difficult to consolidate and to use as a guide for clinical studies30,49,56,64,65.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [49]
Core FXS mouse deficits, including protein synthesis, dendritic spine density and morphology, long-term depression, and audiogenic seizures, are consistently rescued by more than ten genetic approaches and multiple drug classes.
“One striking conclusion of the broad array of preclinical studies is that these core deficits can be consistently rescued by more than ten genetic approaches and multiple classes of pharmacological compounds including mGluR antagonists (MPEP, fenobam, mavoglurant and CTEP), GABA agonists, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), mechanistic target of rapamycin (mTOR) inhib”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [49]
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- Authors
- Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E.
- Affiliations
- New York University (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Klann, Eric
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 2
- Pages
- 325-337
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3479445
- OpenAlex
- W2147609603
- Cited by
- 316
- References
- 65
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 9 · 2023: 23 · 2022: 18 · 2021: 25 · 2020: 28 · 2019: 25 · 2018: 24 · 2017: 38 · 2016: 26 · 2015: 28 · 2014: 32 · 2013: 18 · 2012: 2
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R37NS034007, NS-047384, R01NS034007, R21NS078718, R29NS034007, NS-034007, R01NS047384)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fragile X syndrome, protein synthesis regulation, dendritic spine morphology, social interaction deficits, novel object recognition, behavioral inflexibility, intellectual disability, autism spectrum disorder
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Biophysics, Disease Models, Animal, Electric Stimulation, Exploratory Behavior, Female, Fragile X Syndrome, Gene Expression Regulation, Hippocampus, Interpersonal Relations, Male, Membrane Potentials, Methoxyhydroxyphenylglycol, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Mutation, Neurons, Phenotype, Phosphorylation, Synapses, Patch-Clamp Techniques, Maze Learning, Excitatory Postsynaptic Potentials, Recognition, Psychology, Long-Term Synaptic Depression, Ribosomal Protein S6 Kinases, 70-kDa, Rotarod Performance Test, Extracellular Signal-Regulated MAP Kinases, Dendritic Spines, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein, TOR Serine-Threonine Kinases, In Vitro Techniques
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