Issler, Orna

Sex-specific transcriptional signatures in human depression

Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine

Treatment of Major DepressionStress Responses and Cortisol

Cited by 748

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 394

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

Bagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., et al. (2016) · Neuron

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 333

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron

Treatment of Major DepressionMicroRNA in disease regulation

Cited by 318

Determining the role of microRNAs in psychiatric disorders

Issler, O., & Chen, A. (2015) · Nature Reviews Neuroscience

MicroRNA in disease regulationGenetics and Neurodevelopmental Disorders

Cited by 309

microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34

Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience

MicroRNA in disease regulationStress Responses and Cortisol

Cited by 252

Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Wang, J., Tan, C., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Lorsch, Z. S., Hamilton, P. J., et al. (2020) · Neuron

Treatment of Major DepressionCancer-related molecular mechanisms research

Cited by 156

Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons

Kronman, H., Torres-Berrío, A., Sidoli, S., Issler, O., Godino, A., Ramakrishnan, A., Mews, P., Lardner, C. K., Parise, E. M., Walker, D. M., et al. (2021) · Nature Neuroscience

Stress Responses and CortisolEpigenetics and DNA Methylation

Cited by 108

Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 104

Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis

Kuperman, Y., Issler, O., Regev, L., Musseri, I., Navon, I., Neufeld-Cohen, A., Gil, S., & Chen, A. (2010) · Proceedings of the National Academy of Sciences

Neuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Cited by 81

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior

Lepack, A. E., Bagot, R. C., Peña, C. J., Loh, Y.-H. E., Farrelly, L. A., Lu, Y., Powell, S. K., Lorsch, Z. S., Issler, O., Cates, H. M., et al. (2016) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsTreatment of Major Depression

Cited by 63

Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors

Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 58

Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females

Walker, D. M., Zhou, X., Cunningham, A. M., Ramakrishnan, A., Cates, H. M., Lardner, C. K., Peña, C. J., Bagot, R. C., Issler, O., Van der Zee, Y., et al. (2022) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Cited by 20