Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression
Open accessAbstract
Depression is a common disorder that affects women at twice the rate of men. Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differentially expressed genes in the brains of depressed humans and display complex region- and sex-specific patterns of regulation. We identified the primate-specific, neuronal-enriched gene LINC00473 as downregulated in prefrontal cortex (PFC) of depressed females but not males. Using viral-mediated gene transfer to express LINC00473 in adult mouse PFC neurons, we mirrored the human sex-specific phenotype by inducing stress resilience solely in female mice. This sex-specific phenotype was accompanied by changes in synaptic function and gene expression selectively in female mice and, along with studies of human neuron-like cells in culture, implicates LINC00473 as a CREB effector. Together, our studies identify LINC00473 as a female-specific driver of stress resilience that is aberrant in female depression.
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Using whole-genome sequencing, a recent study found that lncRNAs accounted for 30% of the differences between patients with depression and control populations.
“Using whole-genome sequencing, a recent study found that lncRNAs accounted for 30% of the differences between patients with depression and control populations.311”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [311]
The Results section reports that lncRNAs made up about 30% of genes differentially expressed between depressed and control subjects. It describes the method as whole-genome RNA sequencing of postmortem brain tissue, not whole-genome DNA sequencing; the 30% figure refers specifically to differentially expressed genes, not all differences between the groups. (LLM, conf=0.87)
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
Derrien, T., Johnson, R., Bussotti, G., Andrea Tanzer, A., Djebali, S., Tilgner, H., Guernec, G., Martin, D., Merkel, A., Knowles, D. G., et al. (2012) · Genome Research · doi:10.1101/gr.132159.111 · Cited by 5,017 · see citing works
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,011 · see citing works
Unique features of long non-coding RNA biogenesis and function
Quinn, J. J., & Chang, H. Y. (2015) · Nature Reviews Genetics · doi:10.1038/nrg.2015.10 · Cited by 3,653 · see citing works
Cabili, M. N., Trapnell, C., Goff, L. A., Koziol, M. J., Tazón‐Vega, B., Regev, A., & Rinn, J. L. (2011) · Genes & Development · doi:10.1101/gad.17446611 · Cited by 3,473 · see citing works
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356 · see citing works
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001547 · Cited by 3,115 · see citing works
eQTLGen, Wray, N. R., 23andMe, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0090-3 · Cited by 3,005 · see citing works
lincRNAs: Genomics, Evolution, and Mechanisms
Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,596 · see citing works
Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0326-7 · Cited by 2,565 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 3× · see citing works
“For both sexes an accelerated social defeat paradigm (twice daily defeats for 5 d for 10 total defeats) was utilized to capture behavior within the timeframe of HSV expression (Krishnan et al., 2007).”
InfluentialSelf-citationZhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295 · see citing works
Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationRapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works
Seedat, S., Scott, K. M., Angermeyer, M. C., Berglund, P., Bromet, E. J., Brugha, T. S., Demyttenaere, K., de Girolamo, G., Haro, J. M., Jin, R., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.36 · Cited by 1,518 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationThe functions and unique features of long intergenic non-coding RNA
Ransohoff, J. D., Wei, Y., & Khavari, P. A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.104 · Cited by 1,337 · see citing works
The Landscape of long noncoding RNA classification
Laurent, G. S., Wahlestedt, C., & Kapranov, P. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.03.007 · Cited by 1,192 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Self-citationSex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737 · see citing works
Martin, L. A., Neighbors, H. W., & Griffith, D. M. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1985 · Cited by 674 · see citing works
NONCODE 2016: an informative and valuable data source of long non-coding RNAs
Zhao, Y., Li, H., Fang, S., Kang, Y., wu, W., Hao, Y., Li, Z., Bu, D., Sun, N., Zhang, M. Q., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1252 · Cited by 643 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Self-citationWang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550 · see citing works
Self-citationSánchez, C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00046-5 · Cited by 512 · see citing works
Lennox, K. A., & Behlke, M. A. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1206 · Cited by 454 · see citing works
Treatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works
Self-citationHodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Self-citationEarly life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science · doi:10.1126/science.aan4491 · Cited by 394 · see citing works
Self-citationIsolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A
Soderling, S. H., Bayuga, S. J., & Beavo, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7071 · Cited by 374 · see citing works
Chromatin Isolation by RNA Purification (ChIRP)
Chu, C., Quinn, J. J., & Chang, H. Y. (2012) · Journal of Visualized Experiments · doi:10.3791/3912 · Cited by 370 · see citing works
LncATLAS database for subcellular localization of long noncoding RNAs
Mas-Ponte, D., Carlevaro-Fita, J., Palumbo, E., Hermoso, A., Guigó, R., & Johnson, R. (2017) · RNA · doi:10.1261/rna.060814.117 · Cited by 358 · see citing works
Rush, A. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.201 · Cited by 353 · see citing works
Sex differences in the psychopharmacological treatment of depression
Sramek, J. J., Murphy, M. F., & Cutler, N. R. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/ncutler · Cited by 334 · see citing works
Sex differences in psychopathology: of gonads, adrenals and mental illness
Solomon, M. B., & Herman, J. P. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.033 · Cited by 272 · see citing works
Opposite Molecular Signatures of Depression in Men and Women
Seney, M. L., Huo, Z., Cahill, K., French, L., Puralewski, R., Zhang, J., Logan, R. W., Tseng, G., Lewis, D. A., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.017 · Cited by 272 · see citing works
The Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works
Yang, C., Seamans, J. K., & Gorelova, N. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01904.1996 · Cited by 257 · see citing works
Establishment of a repeated social defeat stress model in female mice
Takahashi, A., Chung, J.-R., Zhang, S., Zhang, H., Grossman, Y., Aleyasin, H., Flanigan, M. E., Pfau, M. L., Menard, C., Dumitriu, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12811-8 · Cited by 256 · see citing works
Self-citationmicroRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34
Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252 · see citing works
Self-citationβ-catenin mediates stress resilience through Dicer1/microRNA regulation
Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240 · see citing works
Self-citationPorcu, E., Medici, M., Pistis, G., Volpato, C. B., Wilson, S. G., Cappola, A. R., Bos, S. D., Deelen, J., den Heijer, M., Freathy, R. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003266 · Cited by 229 · see citing works
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth
Chen, Z., Li, J., Lin, S., Cao, C., Gimbrone, N. T., Yang, R., Fu, D., Carper, M. B., Haura, E. B., Schabath, M. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85250 · Cited by 192 · see citing works
The Role of Xist in X-Chromosome Dosage Compensation
Sahakyan, A., Yang, Y., & Plath, K. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.05.005 · Cited by 162 · see citing works
Hoffman, G. E., Hartley, B. J., Flaherty, E. K., Ladran, I., Gochman, P., Ruderfer, D. M., Stahl, E. A., Rapoport, J. L., Sklar, P. B., & Brennand, K. (2017) · Nature Communications · doi:10.1038/s41467-017-02330-5 · Cited by 158 · see citing works
Self-citationIntegrating the roles of long and small non-coding RNA in brain function and disease
Barry, G. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.196 · Cited by 150 · see citing works
Evolution of Osteocrin as an activity-regulated factor in the primate brain
Ataman, B., Boulting, G. L., Harmin, D. A., Yang, M. G., Baker-Salisbury, M., Yap, E.-L., Malik, A. N., Mei, K., Rubin, A. A., Spiegel, I., et al. (2016) · Nature · doi:10.1038/nature20111 · Cited by 149 · see citing works
Chromatin Isolation by RNA Purification (ChIRP)
Chu, C., Quinn, J. J., & Chang, H. Y. (2012) · Journal of Visualized Experiments · doi:10.3791/3912-v · Cited by 135 · see citing works
Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs
Chujo, T., Yamazaki, T., Kawaguchi, T., Kurosaka, S., Takumi, T., Nakagawa, S., & Hirose, T. (2017) · The EMBO Journal · doi:10.15252/embj.201695848 · Cited by 132 · see citing works
Substantial DNA methylation differences between two major neuronal subtypes in human brain
Kozlenkov, A., Wang, M., Roussos, P., Rudchenko, S., Barbu, M., Bibikova, M. V., Klotzle, B., Dwork, A. J., Zhang, B., Hurd, Y. L., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1304 · Cited by 125 · see citing works
Liu, Z., Li, X., Sun, N., Xu, Y. J., Meng, Y.-Q., Yang, C., Wang, Y., & Zhang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093388 · Cited by 121 · see citing works
Dunn, E. C., Wiste, A. K., Radmanesh, F., Almli, L. M., Gogarten, S. M., Sofer, T., Faul, J. D., Kardia, S. L. R., Smith, J. A., Weir, D. R., et al. (2016) · Depression and Anxiety · doi:10.1002/da.22484 · Cited by 114 · see citing works
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
Lorsch, Z. S., Hamilton, P. J., Ramakrishnan, A., Parise, E. M., Salery, M., Wright, W. J., Lepack, A. E., Mews, P., Issler, O., McKenzie, A. T., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0462-8 · Cited by 111 · see citing works
Self-citationEstrogen receptor α drives pro-resilient transcription in mouse models of depression
Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works
Self-citationDatson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O. B., Goeman, J. J., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2010) · Hippocampus · doi:10.1002/hipo.20905 · Cited by 100 · see citing works
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N.-Y., Dias, C., Rabkin, J., Koo, J. W., Korb, E., Bagot, R. C., Ahn, F. H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3939 · Cited by 91 · see citing works
Self-citationOrsetti, M., Brisco, F. D., Canonico, P. L., Genazzani, A. A., & Ghi, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06155.x · Cited by 87 · see citing works
In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
Ruan, X., Li, P., Chen, Y., Shi, Y., Pirooznia, M., Seifuddin, F., Suemizu, H., Ohnishi, Y., Yoneda, N., Nishiwaki, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13688-z · Cited by 87 · see citing works
Dinh, T. A., Vitucci, E. C. M., Wauthier, E., Graham, R. P., Pitman, W. A., Oikawa, T., Chen, M., Silva, G. O., Greene, K. G., Torbenson, M. S., et al. (2017) · Scientific Reports · doi:10.1038/srep44653 · Cited by 86 · see citing works
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
Reinius, B., Shi, C., Hengshuo, L., Sandhu, K. S., Radomska, K. J., Rosen, G. D., Lu, L., Kullander, K., Williams, R. W., & JAZIN, E. E. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-614 · Cited by 81 · see citing works
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
Volk, N., Pape, J. C., Engel, M., Zannas, A. S., Cattane, N., Cattaneo, A., Binder, E. B., & Chen, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.038 · Cited by 79 · see citing works
Zhu, S., Fu, W., Zhang, L., Fu, K., Hu, J., Jia, W., & Liu, G. (2017) · Cell Proliferation · doi:10.1111/cpr.12416 · Cited by 79 · see citing works
Li, Y., Pehrson, A. L., Waller, J. A., Dale, E., Sánchez, C., & Gulinello, M. E. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00279 · Cited by 78 · see citing works
Kalil, B., Leite, C., Carvalho-Lima, M., & Anselmo-Franci, J. (2013) · Stress · doi:10.3109/10253890.2013.777832 · Cited by 78 · see citing works
Pruunsild, P., Bengtson, C. P., & Bading, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.018 · Cited by 78 · see citing works
Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Zhou, Y., Lutz, P.-E., Wang, Y. C., Ragoussis, J., & Turecki, G. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0267-7 · Cited by 77 · cited 4× · see citing works
“Descriptive studies profiling lncRNAs in humans have found differences in rACC (Zhou et al., 2018) and blood (Liu et al.”
InfluentialAmygdala NRG1–ErbB4 Is Critical for the Modulation of Anxiety-Like Behaviors
Bi, L.-L., Sun, X.-D., Zhang, J., Lu, Y.-S., Chen, Y.-H., Wang, J., Geng, F., Liu, F., Zhang, M., Liu, J.-H., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.274 · Cited by 76 · see citing works
Self-citationNeuronal Rho GEFs in Synaptic Physiology and Behavior
Miller, M. B., Yan, Y., Eipper, B. A., & Mains, R. E. (2013) · The Neuroscientist · doi:10.1177/1073858413475486 · Cited by 74 · see citing works
Carson, R. P., Fu, C., Winzenburger, P. A., & Ess, K. C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds414 · Cited by 69 · see citing works
Chen, H., Yang, F., Li, X., Gong, Z., & Wang, L.-W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.215 · Cited by 66 · see citing works
Zhang, L., Wang, Y., Li, X., Xia, X., Li, N., He, R., He, H., Han, C., & Zhao, W. (2017) · Neoplasia · doi:10.1016/j.neo.2017.08.008 · Cited by 59 · see citing works
Shi, C., Yang, Y., Yu, J., Meng, F., Zhang, T., & Gao, Y. (2017) · Europe PMC (PubMed Central) · Cited by 57 · see citing works
Liang, X., Deng, W., Liu, Y., Liang, Y., Fan, Z.-M., Gu, X., Liu, J., Sha, A., Diao, H., & Yang, Z. (2016) · Scientific Reports · doi:10.1038/srep22744 · Cited by 57 · see citing works
LINC00473 promotes the Taxol resistance via miR-15a in colorectal cancer
Wang, L., Zhang, X., Li, S., Qiu, C., & Luo, R. (2018) · Bioscience Reports · doi:10.1042/bsr20180790 · Cited by 56 · see citing works
Chen, Z., Lin, S., Li, J., Wei Min, N. I., Guo, R., Lu, J., Kaye, F. J., & Wu, L. (2018) · Oncogene · doi:10.1038/s41388-017-0104-0 · Cited by 51 · see citing works
Cereseto, M., Reinés, A. G., Ferrero, A., Sifonios, L. L., Rubio‐Terres, C., & Wikinski, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05232.x · Cited by 50 · see citing works
Chung, D., Chung, Y., Bazmi, H., & Lewis, D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0169-7 · Cited by 50 · see citing works
Dang, R., Cai, H., Zhang, L., Liang, D., Lv, C., Guo, Y., Yang, R., Zhu, Y., & Jiang, P. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.11.023 · Cited by 45 · see citing works
LINC00473 predicts poor prognosis and regulates cell migration and invasion in gastric cancer
Zhang, W., & Song, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.061 · Cited by 45 · see citing works
Ye, N., Rao, S., Du, T., Hu, H., Liu, Z., Shen, Y., & Xu, Q. (2016) · Gene · doi:10.1016/j.gene.2016.11.041 · Cited by 44 · see citing works
Wu, D., Xu, Y., Zou, Y., Zuo, Q., Huang, S., Wang, S., Lu, X., He, X., Wang, J., Wang, T., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.020 · Cited by 44 · see citing works
Self-citationCui, X., Niu, W., Kong, L., He, M., Jiang, K., Chen, S., Zhong, A., Li, W., Lu, J. Z., & Zhang, L. (2017) · Brain and Behavior · doi:10.1002/brb3.711 · Cited by 42 · see citing works
Wang, Q., Roy, B., & Dwivedi, Y. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0448-z · Cited by 42 · see citing works
Altered expression of long noncoding RNAs in patients with major depressive disorder
Seki, T., Yamagata, H., Uchida, S., Chen, C., Kobayashi, A., Kobayashi, M., Harada, K., Matsuo, K., Watanabe, Y., & Nakagawa, S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.07.004 · Cited by 42 · see citing works
Anderson, E. M., Sun, H., Guzman, D. D., Taniguchi, M., Cowan, C. W., Maze, I. S., Nestler, E. J., & Self, D. W. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0305-4 · Cited by 40 · see citing works
Self-citationRoy, B., Wang, Q., & Dwivedi, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy010 · Cited by 38 · see citing works
Pei, Q., Burnet, P. J. W., & Zetterström, T. (1998) · Neuroreport · doi:10.1097/00001756-199802160-00006 · Cited by 37 · see citing works
Malki, K., Lourdusamy, A., Binder, E., Paya-Cano, J. L., Sluyter, F., Craig, I., Keers, R., McGuffin, P., Uher, R., & Schalkwyk, L. C. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328356fa90 · Cited by 33 · see citing works
Zeng, Y., Navarro, P., Shirali, M., Howard, D. M., Adams, M. J., Hall, L. S., Clarke, T., Thomson, P. A., Smith, B. H., Murray, A. D., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.012 · Cited by 31 · see citing works
Pb, H., Xj, J., Zhang, M., & Ly, G. (2018) · PubMed · doi:10.26355/eurrev_201811_16267 · Cited by 30 · see citing works
Melia, T., & Waxman, D. J. (2019) · Endocrinology · doi:10.1210/en.2018-00949 · Cited by 29 · see citing works
MacMullen, C., Vick, K. A., Pacifico, R., Fallahi‐Sichani, M., & Davis, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.3 · Cited by 27 · see citing works
Hsu, Y., Liao, G., Bi, X., Oka, T., Tamura, S., & Baudry, M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.030 · Cited by 25 · see citing works
Li, C., Cao, F., Li, S., Huang, S., Li, W., & Abumaria, N. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00454 · Cited by 21 · see citing works
Bai, J., Wy, Z., Li, W.-J., Zw, Y., & Jiang, D.-Q. (2019) · PubMed · doi:10.26355/eurrev_201904_17705 · Cited by 20 · see citing works
The molecular basis for sex differences in depression susceptibility
Issler, O., & Nestler, E. J. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.019 · Cited by 19 · see citing works
Self-citationDelacrétaz, A., Preisig, M., Vandenberghe, F., Saigí-Morgui, N., Quteineh, L., Choong, E., Gholam‐Rezaee, M., Kutalik, Z., Magistretti, P. J., Aubry, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139155 · Cited by 18 · see citing works
Deletion of Rictor in catecholaminergic neurons alters locomotor activity and ingestive behavior
Kaska, S., Brunk, R., Bali, V., Kechner, M., & Mazei‐Robison, M. S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.001 · Cited by 8 · see citing works
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Cheng, J., Hu, H., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2024) · General Psychiatry · doi:10.1136/gpsych-2023-101374 · Cited by 216 · see citing works
Neurobiological basis of stress resilience
Nestler, E. J., & Russo, S. J. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.001 · Cited by 137 · see citing works
Self-citationDevelopmental dynamics of RNA translation in the human brain
Duffy, E. E., Finander, B., Choi, G., Carter, A. C., Pritišanac, I., Alam, A., Luria, V., Karger, A., Phu, W., Sherman, M. A., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01164-9 · Cited by 92 · see citing works
Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression
Seney, M. L., Glausier, J. R., & Sibille, E. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.025 · Cited by 96 · see citing works
Sex Differences in Stress Response: Classical Mechanisms and Beyond
Hodes, G. E., Bangasser, D. A., Sotiropoulos, I., Kokras, N., & Dalla, C. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231005090134 · Cited by 95 · see citing works
Defining Valid Chronic Stress Models for Depression With Female Rodents
Lopez, J., & Bagot, R. C. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.010 · Cited by 86 · see citing works
Li, J., Gao, W. F., Zhao, Z., Li, Y., Yang, L., Wei, W., Ren, F., Yang, L., Yu, Y., Duan, W., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02740-7 · Cited by 83 · see citing works
A sex-specific genome-wide association study of depression phenotypes in UK Biobank
Silveira, P. P., Pokhvisneva, I., Howard, D. M., & Meaney, M. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01960-0 · Cited by 81 · see citing works
Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers
Shi, Y., Wang, Q., Song, R., Kong, Y., & Zhang, Z. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103569 · Cited by 79 · see citing works
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75 · see citing works
“with long non-coding RNAs that regulate CREB signaling in the PFC (Issler et al., 2020).”
Non-coding RNA in the wiring and remodeling of neural circuits
Soutschek, M., & Schratt, G. M. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.031 · Cited by 72 · see citing works
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 70 · see citing works
Self-citationThe evolving neurobiology of early-life stress
Birnie, M. T., & Baram, T. Z. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.016 · Cited by 65 · see citing works
Silva, R. C., Pisanu, C., Maffioletti, E., Menesello, V., Bortolomasi, M., Gennarelli, M., Baune, B. T., Squassina, A., & Minelli, A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.012 · Cited by 53 · see citing works
The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression
Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Xia, S.-H., Zinsmaier, A. K., Tan, C., Li, W., Browne, C. J., Walker, D. M., Salery, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9494 · Cited by 53 · see citing works
Self-citationWei, W., Zhao, Q., Wang, Z., Liau, W., Basic, D., Ren, H., Marshall, P. R., Zajaczkowski, E. L., Leighton, L. J., Madugalle, S. U., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110546 · Cited by 47 · see citing works
Epigenetic regulation of brain development, plasticity, and response to early-life stress
Peña, C. J. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02179-z · Cited by 51 · see citing works
Self-citationA long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation
Akiki, R. M., Cornbrooks, R. G., Magami, K., Greige, A., Snyder, K. K., Wood, D. J., Herrington, C. M., Mace, P., Blidy, K., Koike, N., et al. (2024) · Science · doi:10.1126/science.adp1562 · Cited by 47 · see citing works
Molecular omics resources should require sex annotation: a call for action
Bond, K. M., McCarthy, M. M., Rubin, J. B., & Swanson, K. R. (2021) · Nature Methods · doi:10.1038/s41592-021-01168-6 · Cited by 44 · see citing works
A new perspective on depression and neuroinflammation: Non-coding RNA
Zhou, S., Chen, R., She, Y., Liu, X., Zhao, H., Li, C., & Jia, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.007 · Cited by 42 · see citing works
Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
Mansouri, S., Pessoni, A. M., Marroquín-Rivera, A., Parise, E. M., Tamminga, C. A., Turecki, G., Nestler, E. J., Chen, T., & Labonté, B. (2023) · Nature Communications · doi:10.1038/s41467-023-42686-5 · Cited by 42 · see citing works
Self-citationEmerging roles of long non-coding RNA in depression
Hao, W.-Z., Chen, Q., Wang, L., Tao, G., Gan, H., Deng, L.-J., Huang, J.-Q., & Chen, J.-X. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110515 · Cited by 37 · see citing works
Hu, X., Zhang, L., Liang, K., Cao, L., Liu, J., Li, H., Gao, Y., Hu, X., Hu, Y., Kuang, W., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01252-7 · Cited by 36 · see citing works
lncRNA MIR155HG Alleviates Depression-Like Behaviors in Mice by Regulating the miR-155/BDNF Axis
Zhang, H., Mei, Z., Huang, N., Ma, X., Yaping, W., Liu, L., Wang, L., Kejin, Z., & Liu, Y. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03234-z · Cited by 35 · see citing works
Role of Long Noncoding RNA Gas5 in Cocaine Action
Xu, H., Brown, A. N., Waddell, N. J., Liu, X., Kaplan, G. J., Chitaman, J. M., Stockman, V., Hedinger, R. L., Adams, R., Abreu, K., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.004 · Cited by 33 · see citing works
Self-citationChen, H.-S., Wang, J., Li, H., Wang, X., Zhang, S.-Q., Deng, T., Li, Y.-K., Zou, R.-S., Wang, H.-J., Zhu, R., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn2496 · Cited by 31 · see citing works
Self-citationZhou, T., Li, M., Xiao, Z., Cai, J. Q., Zhao, W., Duan, J., Yang, Z., Guo, Z., Chen, Y., Cai, W., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.744251 · Cited by 29 · see citing works
Xu, Y., Jiang, Y., Wang, Y., Jia, B., Gao, S., Yu, H., Zhang, H., Lv, C., Li, H., & Li, T. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10275 · Cited by 29 · see citing works
Sperm Transcriptional State Associated with Paternal Transmission of Stress Phenotypes
Cunningham, A. M., Walker, D. M., Ramakrishnan, A., Doyle, M. A., Bagot, R. C., Cates, H. M., Peña, C. J., Issler, O., Lardner, C. K., Browne, C. J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3192-20.2021 · Cited by 27 · see citing works
Self-citationMean Girls: Social Stress Models for Female Rodents
Kuske, J. X., & Trainor, B. C. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_247 · Cited by 27 · see citing works
The noncoding genome and hearing loss
Avraham, K. B., Khalaily, L., Noy, Y., Kamal, L., Koffler-Brill, T., & Taiber, S. (2021) · Human Genetics · doi:10.1007/s00439-021-02359-z · Cited by 26 · see citing works
Iyer, N. R., Shin, J., Cuskey, S., Tian, Y., Nicol, N. R., Doersch, T. E., Seipel, F., McCalla, S. G., Roy, S., & Ashton, R. S. (2022) · Science Advances · doi:10.1126/sciadv.abn7430 · Cited by 28 · see citing works
Translating the Transcriptome: Sex Differences in the Mechanisms of Depression and Stress, Revisited
Rainville, J. R., Lipuma, T., & Hodes, G. E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.003 · Cited by 25 · see citing works
Neuroepigenetics of psychiatric disorders: Focus on lncRNA
Jovčevska, I., & Paska, A. V. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105140 · Cited by 25 · see citing works
Sex-specific effects of social defeat stress on miRNA expression in the anterior BNST
Luo, P. X., Manning, C., Fass, J. N., Williams, A. V., Hao, R., Campi, K. L., & Trainor, B. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113084 · Cited by 25 · see citing works
Advances in biosensors for major depressive disorder diagnostic biomarkers
Dong, T., Yu, C., Mao, Q., Han, F., Yang, Z., Yang, Z., Pires, N. M. M., Wei, X., Jing, W., Lin, Q., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116291 · Cited by 25 · see citing works
Takahashi, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.644161 · Cited by 24 · see citing works
The molecular basis of depression: implications of sex-related differences in epigenetic regulation
Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23 · see citing works
Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility
van der Zee, Y. Y., Lardner, C. K., Parise, E. M., Mews, P., Ramakrishnan, A., Patel, V., Teague, C. D., Salery, M., Walker, D. M., Browne, C. J., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.019 · Cited by 23 · see citing works
Self-citationLong-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function
Bendersky, C. J., Milian, A. A., Andrus, M. D., Torre, U. D. L., & Walker, D. M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.745406 · Cited by 23 · see citing works
Self-citationRelationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease
Fass, S. B., Mulvey, B., Chase, R., Yang, W. C., Selmanovic, D., Chaturvedi, S. M., Tycksen, E., Weiss, L. A., & Dougherty, J. D. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00622-2 · Cited by 25 · see citing works
Epigenetic mechanisms in depression: Implications for pathogenesis and treatment
Chen, H.-S., Wang, F., & Chen, J. (2024) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2024.102854 · Cited by 23 · see citing works
Hicks, E. M., Seah, C., Cote, A. C., Marchese, S., Brennand, K., Nestler, E. J., Girgenti, M. J., & Huckins, L. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02412-7 · Cited by 20 · see citing works
Self-citationFulton, S. L., Bendl, J. M., Salvo, G. D., Fullard, J. F., Al-Kachak, A., Lepack, A. E., Stewart, A. F., Singh, S., Poller, W. C., Bastle, R. M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.023 · Cited by 22 · see citing works
Self-citationWalker, D. M., Zhou, X., Cunningham, A. M., Ramakrishnan, A., Cates, H. M., Lardner, C. K., Peña, C. J., Bagot, R. C., Issler, O., Van der Zee, Y., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.026 · Cited by 20 · see citing works
Self-citationCuttoli, R. D.-D., Martínez-Rivera, F. J., Li, L., Minier-Toribio, A. M., Cathomas, F., Holt, L. M., Yasmin, F., Elhassa, S., Shaikh, J. F., Ahmed, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.add5579 · Cited by 21 · see citing works
Self-citationZhang, S., Sun, Y., Xiao, Q., Niu, M., Pan, X., & Zhu, X. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03214-0 · Cited by 20 · see citing works
Mou, R., Ma, J., Ju, X., Wu, Y., Chen, Q., Li, J., Shang, T., Chen, S., Yang, Y., Li, Y., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.09.018 · Cited by 20 · see citing works
Zheng, H., & Jia, C. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.007 · Cited by 19 · see citing works
Proaño, S. B., Miller, C. K., Krentzel, A. A., Dorris, D. M., & Meitzen, J. (2023) · Steroids · doi:10.1016/j.steroids.2023.109344 · Cited by 18 · see citing works
Truby, N. L., Kim, R. K., Silva, G. M., Qu, X., Picone, J. A., Alemu, R., Atiyeh, C. N., Neve, R. L., Liu, J., Cui, X., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02775-5 · Cited by 19 · see citing works
Self-citationEpigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Stoccoro, A. (2025) · Biology · doi:10.3390/biology14010098 · Cited by 17 · see citing works
LncRNAs in neuropsychiatric disorders and computational insights for their prediction
Baruah, C., Nath, P., & Barah, P. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07819-x · Cited by 17 · see citing works
Jiao, J., Xu, D., Kong, Y., Cao, Y., Wang, L., Hong, Y., Li, L., Gao, C., Liu, J., Zhang, G., et al. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.06.021 · Cited by 17 · see citing works
Roy, B., Verma, A. K., Funahashi, Y., & Dwivedi, Y. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70135 · Cited by 16 · see citing works
Gibbons, A. S., Sundram, S., & Dean, B. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030033 · Cited by 16 · see citing works
ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core
Miller, C. K., Krentzel, A. A., & Meitzen, J. (2023) · Neuroendocrinology · doi:10.1159/000529571 · Cited by 16 · see citing works
Touchant, M., & Labonté, B. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.845491 · Cited by 14 · see citing works
Self-citationSex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition
Reis, A. L. M., Hammond, J. W., Stevanovski, I., Arnold, J. C., McGregor, I. S., Deveson, I. W., & Gururajan, A. (2022) · iScience · doi:10.1016/j.isci.2022.104861 · Cited by 16 · see citing works
What Do the Animal Studies of Stress Resilience Teach Us?
Dziedzicka‐Wasylewska, M., Solich, J., Korlatowicz, A., & Faron‐Górecka, A. (2021) · Cells · doi:10.3390/cells10071630 · Cited by 15 · see citing works
Increasing resolution in stress neurobiology: from single cells to complex group behaviors
Miranda, L., Bordes, J., Gasperoni, S., & López, J. P. (2023) · Stress · doi:10.1080/10253890.2023.2186141 · Cited by 15 · see citing works
Recent developments in omics studies and artificial intelligence in depression and suicide
Wang, Q., & Dwivedi, Y. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03497-y · Cited by 14 · see citing works
Popa, N., Bachar, D., Roberts, A., Santangelo, A. M., & Gascon, E. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104159 · Cited by 13 · see citing works
Ding, X., Lin, Y., Yan, B., Jiao, X., Liu, Q., Miao, H., Wu, Y., & Zhou, C. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.10.006 · Cited by 13 · see citing works
Ma, R. K., Tsai, P.-Y., Farghli, A. R., Shumway, A. J., Kanke, M., Gordan, J. D., Gujral, T. S., Vakili, K., Nukaya, M., Noetzli, L. J., et al. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011216 · Cited by 13 · see citing works
Zou, Y., Gao, B., Lu, J., Zhang, K., Zhai, M., Yuan, Z., Aschner, M., Chen, J., Luo, W., Wang, L., et al. (2024) · Exploration · doi:10.1002/exp.20230154 · Cited by 13 · see citing works
LINC00473: A novel oncogenic long noncoding RNA in human cancers
Li, L., Zhang, X., Liu, N., Chen, X., & Peng, C. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30176 · Cited by 13 · see citing works
Sex Differences in Susceptibility to Depression: A Role for LncRNAs
Gururajan, A. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.016 · Cited by 12 · see citing works
Zhong, X.-L., Du, Y., Chen, L. T., & Cheng, Y. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.06.017 · Cited by 12 · see citing works
The emerging roles of long non-coding RNAs in the nervous system
Altaf, S., Cummins, M. J., Ittner, L. M., & Mattick, J. S. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00960-z · Cited by 14 · see citing works
Regulation of LncRNAs and microRNAs in neuronal development and disease
Xuan, C., Yang, E., Zhao, S., Xu, J., Li, P., Zhang, Y., Jiang, Z., & Ding, X. (2023) · PeerJ · doi:10.7717/peerj.15197 · Cited by 12 · see citing works
He, L., Zou, P., Sun, W., Fu, Y., He, W., & Li, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-94122-7 · Cited by 12 · see citing works
Long non-coding RNAs expression and regulation across different brain regions in primates
Navandar, M., Vennin, C., Lutz, B., & Gerber, S. (2024) · Scientific Data · doi:10.1038/s41597-024-03380-3 · Cited by 13 · see citing works
Chao, G., Zhang, L., Zhan, Z., & Bao, Y. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-081776 · Cited by 11 · see citing works
The neural basis underlying female vulnerability to depressive disorders
Kim, M., Kim, W., & Chung, C. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2276815 · Cited by 11 · see citing works
Sex Significantly Impacts the Function of Major Depression–Linked Variants In Vivo
Mulvey, B., Selmanovic, D., & Dougherty, J. D. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.02.009 · Cited by 12 · see citing works
Brain and Blood Biomarkers of Major Depressive Disorder
Zallar, L. J., & Dupont, M. B. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.4613 · Cited by 12 · see citing works
Mulvey, B., Wang, Y., Divecha, H. R., Bach, S. V., Montgomery, K. D., Cinquemani, S., Chandra, A., Du, Y., Miller, R. A., Kleinman, J. E., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116877 · Cited by 10 · see citing works
Guo, Z., Liang, E., Zhang, T., Xu, M., Jiang, X., & Zhi, F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.607748 · Cited by 10 · see citing works
Wu, K., Ma, F., Shen, J., Zhang, H., Wan, Y., He, X., Yang, A., Xiong, J., Jiao, Y., Bai, Z., et al. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022181 · Cited by 10 · see citing works
Petrican, R., Paine, A. L., Escott‐Price, V., & Shelton, K. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-28057-6 · Cited by 11 · see citing works
SNORA69 is up-regulated in the lateral habenula of individuals with major depressive disorder
Lin, R., Mitsuhashi, H., Fiori, L. M., Denniston, R., Ibrahim, E. C., Belzung, C., Mechawar, N., & Turecki, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-58278-2 · Cited by 9 · see citing works
Sex-specific role for the long noncoding RNA Pnky in mouse behavior
Saha, P., Andersen, R., Hong, S. J., Gil, E., Simms, J. A., Choi, H., & Lim, D. A. (2024) · Nature Communications · doi:10.1038/s41467-024-50851-7 · Cited by 9 · see citing works
Pruunsild, P., Bengtson, C. P., Loss, I., Lohrer, B., & Bading, H. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104671 · Cited by 8 · see citing works
Gururajan, A., Bastiaanssen, T. F. S., Silva, A. P. V., Moloney, G. M., & Cryan, J. F. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15567 · Cited by 8 · see citing works
RNA Modifications in the Central Nervous System
Wang, D. O. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.23 · Cited by 7 · see citing works
Gururajan, A. (2022) · Stress · doi:10.1080/10253890.2022.2111211 · Cited by 7 · see citing works
Nie, K., Liu, L., Peng, L., Zhang, M., Zhang, C., Xiao, B., Xia, Z., & Huang, W. J. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-01971-6 · Cited by 7 · see citing works
Wang, Q., Wang, H., & Dwivedi, Y. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100365 · Cited by 6 · see citing works
Mei, Y.-X., Chen, H.-S., Cao, Q.-L., Lv, W., Liu, Y., Deng, S., Zhou, Q., Zhang, Z., Wang, F., Hu, Z., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03239-y · Cited by 6 · see citing works
Mahmud, A., & Karaman, M. A. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1843871 · Cited by 7 · see citing works
Cuttoli, R. D.-D., Issler, O., Pedersen, S., Yakubov, B., Jahan, N., Abid, A., Kasparov, S., Granizo, K., Ahmed, S., Russo, S. J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr3228 · Cited by 6 · see citing works
Self-citationLiang, P., Sun, Y., Li, Y., & Liang, Y. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s393498 · Cited by 6 · see citing works
An emerging link between lncRNAs and cancer sex dimorphism
Naciri, I., Ludena, M. D. L. A., Yang, Y., Kong, M., & Sun, S. (2023) · Human Genetics · doi:10.1007/s00439-023-02620-7 · Cited by 6 · see citing works
Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Lu, Y., Shang, R., Zhong, X., Shi, J., Zhang, G., Zhao, W., & Teng, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616322 · Cited by 6 · see citing works
Dwivedi, Y., & Roy, B. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03396-0 · Cited by 5 · see citing works
Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons
Huang, Y., Michalski, C., Zhou, Y., Xu, C., Niu, W., Lucido, M. J., Wang, J., Feng, Y., Miller, A. H., & Wen, Z. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-025-02320-y · Cited by 5 · see citing works
Self-citationZhu, L., Guo, M., Li, K., Guo, C., & He, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010995 · Cited by 5 · see citing works
Zou, Z., Ye, Y., Zhou, B., & Zhang, Y. (2023) · World Journal of Psychiatry · doi:10.5498/wjp.v13.i2.36 · Cited by 5 · see citing works
- Authors
- Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Wang, J., Tan, C., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Lorsch, Z. S., Hamilton, P. J., Peña, C. J., Flaherty, E., Hartley, B. J., Torres-Berrío, A., Parise, E. M., Kronman, H., Duffy, J. E., Estill, M. S., Calipari, E. S., Labonté, B., Neve, R. L., Tamminga, C. A., Brennand, K. J., Dong, Y., Shen, L., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Pittsburgh (US)
- The University of Texas Southwestern Medical Center (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Nestler, Eric J.
- ORCID
- Issler, Orna
- Ramakrishnan, Aarthi
- Wang, Junshi
- Tan, Chunfeng
- Loh, Yong-Hwee E.
- Walker, Deena M.
- Lorsch, Zachary S.
- Hamilton, Peter J.
- Peña, Catherine J.
- Flaherty, Erin
- Parise, Eric M.
- Kronman, Hope
- Estill, Molly S.
- Calipari, Erin S.
- Neve, Rachael L.
- Tamminga, Carol A.
- Brennand, Kristen J.
- Dong, Yan
- Shen, Li
- Nestler, Eric J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 106
- Issue
- 6
- Pages
- 912-926.e5
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7305959
- OpenAlex
- W3017236879
- Cited by
- 156
- References
- 105
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 25 · 2023: 32 · 2022: 25 · 2021: 27 · 2020: 8
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Hope for Depression Research Foundation
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- LINC00473, long non-coding RNA, depression, sex differences, stress resilience, prefrontal cortex, depression in women, CREB, synaptic function, neuronal gene expression
- MeSH terms
- RNA-Seq, Adult, Aged, Aged, 80 and over, Animals, Behavior, Animal, Depression, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Mice, Transgenic, Middle Aged, Neurons, Sex Factors, Stress, Psychological, Down-Regulation, Prefrontal Cortex, Mice, Resilience, Psychological, Young Adult, RNA, Long Noncoding
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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