Determining the role of microRNAs in psychiatric disorders
Abstract
Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular miRNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain miRNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain miRNAs could become novel treatment targets for psychiatric disorders.
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miRNAs regulate gene expression through translational repression and inhibition, and they are viable targets for intervention in neuropsychiatric disease.
“miRNAs regulate gene expression through translational repression and inhibition, and they are viable targets for intervention in neuropsychiatric disease (Issler and Chen, 2015;O'Connor et al., 2013;Scott et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Issler and Chen, 2015
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- Authors
- Issler, O., & Chen, A.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Issler, Orna
- Chen, Alon
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-03-20
- Volume
- 16
- Issue
- 4
- Pages
- 201-212
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2015431173
- Cited by
- 309
- References
- 20
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 25 · 2023: 13 · 2022: 27 · 2021: 34 · 2020: 35 · 2019: 33 · 2018: 35 · 2017: 33 · 2016: 33 · 2015: 12
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- microRNA, mental illness, circulating microRNAs, non-coding RNA, microRNA expression profiles, animal models of psychiatric disorders, behavioral regulation, treatment goals
- MeSH terms
- Animals, Behavior, Mental Disorders, Brain, Humans, MicroRNAs
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