Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility
Open accessAbstract
Depression is a complex, heterogeneous disorder and a leading contributor to the global burden of disease. Most previous research has focused on individual brain regions and genes contributing to depression. However, emerging evidence in humans and animal models suggests that dysregulated circuit function and gene expression across multiple brain regions drive depressive phenotypes. Here, we performed RNA sequencing on four brain regions from control animals and those susceptible or resilient to chronic social defeat stress at multiple time points. We employed an integrative network biology approach to identify transcriptional networks and key driver genes that regulate susceptibility to depressive-like symptoms. Further, we validated in vivo several key drivers and their associated transcriptional networks that regulate depression susceptibility and confirmed their functional significance at the levels of gene transcription, synaptic regulation, and behavior. Our study reveals novel transcriptional networks that control stress susceptibility and offers fundamentally new leads for antidepressant drug discovery.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other findings have identified widespread transcriptional changes in the NAc of chronically stressed mice.
“other findings have identified widespread transcriptional changes in the NAc of chronically stressed mice. 54”
From Epigenetics and depression (2019) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,373 · see citing works
A General Framework for Weighted Gene Co-Expression Network Analysis
Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684 · see citing works
Self-citationZhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846 · see citing works
Margolin, A. A., Nemenman, I., Basso, K., Wiggins, C., Stolovitzky, G., Favera, R. D., & Califano, A. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-s1-s7 · Cited by 2,420 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 5× · see citing works
“C, suggesting a lack of specificity within AMY that may relate to findings of elevated anxiety in both susceptible and resilient mice (Krishnan et al., 2007).”
InfluentialSelf-citationMargolin, A. A., Nemenman, I. M., Basso, K., Wiggins, C. H., Stolovitzky, G. A., Favera, R. D., & Califano, A. (2006) · BMC Bioinformatics · doi:10.7916/d8g15zbp · Cited by 2,260 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationThe mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Self-citationDefining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R
Langfelder, P., Zhang, B., & Horvath, S. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btm563 · Cited by 1,892 · see citing works
Self-citationThe Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
Greenberg, P. E., Fournier, A.-A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09298 · Cited by 1,779 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Self-citationMayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115 · see citing works
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
Parikshak, N. N., Luo, R., Zhang, A., Won, H., Lowe, J. K., Chandran, V., Horvath, S., & Geschwind, D. H. (2013) · Cell · doi:10.1016/j.cell.2013.10.031 · Cited by 1,039 · see citing works
Self-citationDeep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
Groenewegen, H. J., Vermeulen‐Vanderzee, E., Kortschot, A. T., & Witter, M. P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90275-2 · Cited by 867 · see citing works
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808 · see citing works
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Self-citationVentral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491 · see citing works
Self-citationEnhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience
Friedman, A. K., Walsh, J. J., Juarez, B., Ku, S. M., Chaudhury, D., Wang, J., Li, X., Dietz, D. M., Pan, N., Vialou, V. F., et al. (2014) · Science · doi:10.1126/science.1249240 · Cited by 484 · see citing works
Self-citationPlaisier, S. B., Taschereau, R., Wong, J. A., & Graeber, T. G. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq636 · Cited by 468 · see citing works
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464 · see citing works
Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works
Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina
Yamagata, M., & Sanes, J. R. (2008) · Nature · doi:10.1038/nature06469 · Cited by 378 · see citing works
Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378 · see citing works
Limbic and cortical information processing in the nucleus accumbens
Goto, Y., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.002 · Cited by 332 · see citing works
Yamagata, M., Weiner, J. A., & Sanes, J. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00910-8 · Cited by 322 · see citing works
Gaiteri, C., Ding, Y., French, B., Tseng, G. C., & Sibille, E. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12106 · Cited by 289 · see citing works
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · cited 2× · see citing works
“…regions have been reported in both rodent depression models and depressed humans (Bagot et al., 2015; Chang et al., 2014; Covington et al., 2010; Ding et al., 2015; Guilloux et al., 2012; Jaworska et al., 2014; Kennedy et al., 2001; Mayberg et al., 2000; Sequeira et al., 2009; Vialou et al., 2014).”
Self-citationGenes and pathways underlying regional and cell type changes in Alzheimer’s disease
Miller, J. A., Woltjer, R. L., Goodenbour, J. M., Horvath, S., & Geschwind, D. H. (2013) · Genome Medicine · doi:10.1186/gm452 · Cited by 275 · see citing works
Self-citationAntidepressants Normalize the Default Mode Network in Patients With Dysthymia
Posner, J., Hellerstein, D. J., Gat, I., Mechling, A., Klahr, K., Wang, Z., McGrath, P. J., Stewart, J. W., & Peterson, B. S. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.455 · Cited by 268 · see citing works
Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
Self-citationβ-catenin mediates stress resilience through Dicer1/microRNA regulation
Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature · doi:10.1038/nature13976 · Cited by 240 · see citing works
Self-citationLocus-specific epigenetic remodeling controls addiction- and depression-related behaviors
Heller, E. A., Cates, H. M., Peña, C. J., Sun, H., Shao, N., Feng, J., Golden, S. A., Herman, J. P., Walsh, J. J., Mazei-Robison, M., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3871 · Cited by 227 · see citing works
Self-citationTham, M. W., Woon, P. S., Sum, M. Y., Lee, T.-S. W., & Sim, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.013 · Cited by 206 · see citing works
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.035 · Cited by 201 · see citing works
Self-citationPhilip, N. S., Carpenter, L. L., Tyrka, A. R., & Price, L. H. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1932-6 · Cited by 185 · see citing works
Buijs, R. M., & van Eden, C. G. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26011-1 · Cited by 176 · see citing works
NeuroD2 Is Necessary for Development and Survival of Central Nervous System Neurons
Olson, J. M., Asakura, A., Snider, L. D., Hawkes, R. B., Strand, A. D., Stoeck, J., Hallahan, A. R., Pritchard, J. I., & Tapscott, S. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0245 · Cited by 174 · see citing works
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162 · see citing works
Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.034 · Cited by 142 · see citing works
A review of fMRI studies during visual emotive processing in major depressive disorder
Jaworska, N., Yang, X.-R., Knott, V., & MacQueen, G. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.885659 · Cited by 133 · see citing works
Chang, L., Jamain, S., Lin, C., Rujescu, D., Tseng, G. C., & Sibille, E. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090980 · Cited by 104 · see citing works
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
Christoffel, D. J., Golden, S. A., Walsh, J. J., Guise, K. G., Heshmati, M., Friedman, A. K., Dey, A., Smith, M., Rebusi, N., Pfau, M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4034 · Cited by 101 · see citing works
Hooley, J. M., Gruber, S. A., Parker, H. A., Guillaumot, J., Rogowska, J., & Yurgelun-Todd, D. A. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.04.001 · Cited by 92 · see citing works
Pharmacogenetics of major depressive disorder: top genes and pathways toward clinical applications
Fabbri, C., & Serretti, A. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0594-9 · Cited by 84 · see citing works
Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression
Admon, R., Holsen, L. M., Aizley, H. G., Remington, A., Whitfield, S., Goldstein, J. M., & Pizzagalli, D. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.019 · Cited by 76 · see citing works
Essential role of poly(ADP-ribosyl)ation in cocaine action
Scobie, K. N., Damez-Werno, D. M., Sun, H., Shao, N., Gancarz, A. M., Panganiban, C. H., Dias, C., Koo, J., Caiafa, P., Kaufman, L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319703111 · Cited by 63 · see citing works
Self-citationWhat Does Systems Biology Mean for Drug Development?
Schrattenholz, A. S., & Šoškić, V. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784638843 · Cited by 62 · see citing works
Ding, Y., Chang, L.-C., Wang, X., Guilloux, J.-P., Parrish, J., Oh, H., French, B. J., Lewis, D. A., Tseng, G. C., & Sibille, E. (2015) · Complex Psychiatry · doi:10.1159/000369974 · Cited by 61 · see citing works
Chen, Z.-Q., Du, M., Zhao, Y., Huang, X., Li, J., Lui, S., Hu, J., Sun, H., Liu, J., Kemp, G. J., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140119 · Cited by 60 · see citing works
Self-citationMalki, K., Tosto, M. G., Jumabhoy, I., Lourdusamy, A., Sluyter, F., Craig, I., Uher, R., McGuffin, P., & Schalkwyk, L. C. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.154 · Cited by 55 · see citing works
Emerging antidepressants to treat major depressive disorder
Block, S. G., & Nemeroff, C. B. (2014) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2014.09.001 · Cited by 53 · see citing works
Co-expression network of neural-differentiation genes shows specific pattern in schizophrenia
Maschietto, M. C., Tahira, A. C., Puga, R., Lima, L. D. A., Mariani, D., Paulsen, B. D. S., Belmonte-de-Abreu, P. S., Vieira, H. C., Krepischi, A. C. V., Carraro, D. M., et al. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0098-9 · Cited by 52 · see citing works
NeuroD2 regulates the development of hippocampal mossy fiber synapses
Wilke, S. A., Hall, B. J., Antonios, J. K., DeNardo, L. A., Otto, S. J., Yuan, B., Chen, F., Robbins, E. M., Tiglio, K., Williams, M. E., et al. (2012) · Neural Development · doi:10.1186/1749-8104-7-9 · Cited by 51 · see citing works
Hooley, J. M., Gruber, S. A., Parker, H. A., Guillaumot, J., Rogowska, J., & Yurgelun-Todd, D. A. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.02.001 · Cited by 51 · see citing works
Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-target Drugs
Schrattenholz, A. S., Groebe, K., & Šoškić, V. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-800-3_2 · Cited by 51 · see citing works
Altered Gene Synchrony Suggests a Combined Hormone-Mediated Dysregulated State in Major Depression
Gaiteri, C., Guilloux, J., Lewis, D. A., & Sibille, E. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009970 · Cited by 45 · see citing works
Psychostimulant-Induced Plasticity of Intrinsic Neuronal Excitability in Ventral Subiculum
Cooper, D., Moore, S. J., Staff, N. P., & Spruston, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09937.2003 · Cited by 44 · see citing works
Malki, K., Mineur, Y. S., Tosto, M. G., Campbell, J., Karia, P., Jumabhoy, I., Sluyter, F., Crusio, W. E., & Schalkwyk, L. C. (2015) · BMC Genomics · doi:10.1186/s12864-015-1431-6 · Cited by 38 · see citing works
Gaiteri, C., & Sibille, E. L. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00095 · Cited by 34 · see citing works
Vanderlinden, L. A., Saba, L. M., Kechris, K. J., Miles, M. F., Hoffman, P. L., & Tabakoff, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068878 · Cited by 30 · see citing works
Induction of neural differentiation by the transcription factor NeuroD2
Messmer, K., Shen, W., Remington, M. P., & Fishman, P. S. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.12.006 · Cited by 19 · see citing works
Insel, N., Pilkiw, M., Nóbrega, J. N., Hutchison, W. D., Takehara‐Nishiuchi, K., & Hamani, C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.023 · Cited by 12 · see citing works
Sibbe, M., & Jarowyj, J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2012.12.040 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Yamagata M Weiner JA Sanes JR Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. Cell 2002 110 649 660 12230981
Cited by
Sorted by citations
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Self-citationTreatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works
Self-citationEarly life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science · doi:10.1126/science.aan4491 · Cited by 394 · see citing works
Self-citationNeurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
Self-citationCahill, K. M., Huo, Z., Tseng, G. C., Logan, R. W., & Seney, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-27903-2 · Cited by 294 · see citing works
The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269 · see citing works
Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
Peña, C. J., Smith, M., Ramakrishnan, A., Cates, H. M., Bagot, R. C., Kronman, H. G., Patel, B., Chang, A. B., Purushothaman, I., Dudley, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13085-6 · Cited by 219 · see citing works
Self-citationBrain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability
Hultman, R., Ulrich, K., Sachs, B. D., Blount, C., Carlson, D. E., Ndubuizu, N., Bagot, R. C., Parise, E. M., Vu, M.-A. T., Gallagher, N. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.012 · Cited by 183 · see citing works
Self-citationDescalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1549 · Cited by 188 · see citing works
Self-citationCerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works
Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain’s Reward Circuitry
Walker, D. M., Cates, H. M., Loh, Y. E., Purushothaman, I., Ramakrishnan, A., Cahill, K. M., Lardner, C. K., Godino, A., Kronman, H. G., Rabkin, J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.009 · Cited by 177 · see citing works
Self-citationNeural Substrates of Depression and Resilience
Han, M., & Nestler, E. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0527-x · Cited by 178 · see citing works
Self-citationNectow, A. R., & Nestler, E. J. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00382-z · Cited by 159 · see citing works
Self-citationSIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
Self-citationPhan, B. N., Bohlen, J. F., Davis, B. A., Ye, Z., Chen, H.-Y., Mayfield, B., Sripathy, S. R., Page, S. C., Campbell, M. N., Smith, H. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0578-x · Cited by 144 · see citing works
Behavioural and dopaminergic signatures of resilience
Willmore, L., Cameron, C., Yang, J., Witten, I. B., & Falkner, A. L. (2022) · Nature · doi:10.1038/s41586-022-05328-2 · Cited by 144 · see citing works
Gene expression links functional networks across cortex and striatum
Anderson, K. M., Krienen, F. M., Choi, E. Y., Reinen, J. M., Yeo, B. T. T., & Holmes, A. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03811-x · Cited by 138 · see citing works
Karnib, N., El-Ghandour, R., Hayek, L. E., Nasrallah, P., Khalifeh, M., Barmo, N., Jabre, V., Ibrahim, P., Bilen, M., Stephan, J. S., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0313-z · Cited by 144 · see citing works
Floriou‐Servou, A., von Ziegler, L., Stalder, L., Sturman, O., Privitera, M., Rassi, A., Cremonesi, A., Thöny, B., & Bohacek, J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.003 · Cited by 126 · see citing works
Seney, M. L., Kim, S.-M., Glausier, J. R., Hildebrand, M. A., Xue, X., Zong, W., Wang, J., Shelton, M. A., Phan, B. N., Srinivasan, C., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.06.007 · Cited by 133 · see citing works
Self-citationNeurobiological basis of stress resilience
Nestler, E. J., & Russo, S. J. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.001 · Cited by 137 · see citing works
Self-citationJoëls, M., & de Kloet, E. R. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0660 · Cited by 128 · see citing works
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
Lorsch, Z. S., Hamilton, P. J., Ramakrishnan, A., Parise, E. M., Salery, M., Wright, W. J., Lepack, A. E., Mews, P., Issler, O., McKenzie, A. T., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0462-8 · Cited by 111 · see citing works
Self-citationShared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models
Scarpa, J. R., Fatma, M., Loh, Y. E., Traore, S. R., Stefan, T., Chen, T. H., Nestler, E. J., & Labonté, B. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.029 · Cited by 111 · see citing works
Self-citationSperm microRNAs confer depression susceptibility to offspring
Wang, Y., Chen, Z., Hu, H., Lei, J., Zhou, Z., Yao, B., Chen, L., Liang, G., Zhan, S., Zhu, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd7605 · Cited by 108 · see citing works
Kronman, H., Torres-Berrío, A., Sidoli, S., Issler, O., Godino, A., Ramakrishnan, A., Mews, P., Lardner, C. K., Parise, E. M., Walker, D. M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00814-8 · Cited by 108 · see citing works
Self-citationChromatin organization in the female mouse brain fluctuates across the oestrous cycle
Jarić, I., Rocks, D., Greally, J. M., Suzuki, M., & Kundaković, M. (2019) · Nature Communications · doi:10.1038/s41467-019-10704-0 · Cited by 102 · see citing works
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works
Self-citationAnimal models of depression: pros and cons
Harro, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2973-0 · Cited by 104 · see citing works
Serotonin receptor 4 in the hippocampus modulates mood and anxiety
Karayol, R., Medrihan, L., Warner‐Schmidt, J. L., Fait, B. W., Rao, M. N., Holzner, E. B., Greengard, P., Heintz, N., & Schmidt, E. F. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00994-y · Cited by 103 · see citing works
Le-Niculescu, H., Roseberry, K., Gill, S. S., Levey, D. F., Phalen, P. L., Mullen, J., Williams, A., Bhairo, S., Voegtline, T., Davis, H., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01061-w · Cited by 94 · see citing works
Williams, E. S., Manning, C. E., Eagle, A. L., Swift-Gallant, A., Duque-Wilckens, N., Chinnusamy, S., Moeser, A., Jordan, C., Leinninger, G., & Robison, A. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.006 · Cited by 101 · see citing works
Animal models for the study of depressive disorder
Song, J., & Kim, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13622 · Cited by 104 · see citing works
Wang, X., Pipes, L., Trut, L. N., Herbeck, Y., Vladimirova, A. V., Gulevich, R. G., Kharlamova, A. V., Johnson, J. L., Acland, G. M., Kukekova, A. V., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800889115 · Cited by 100 · see citing works
Lehmann, M. L., Weigel, T. K., Cooper, H. A., Elkahloun, A. G., Kigar, S. L., & Herkenham, M. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-28737-8 · Cited by 96 · see citing works
Sex differences: Transcriptional signatures of stress exposure in male and female brains
Brivio, E., Lopez, J. P., & Chen, A. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12643 · Cited by 95 · see citing works
The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
Wang, Q., Zhang, Y., Wang, M., Song, W.-M., Shen, Q., McKenzie, A., Choi, I., Zhou, X., Pan, P.-Y., Yue, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13144-y · Cited by 121 · see citing works
Self-citationMuir, J., Lopez, J., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0291-6 · Cited by 92 · see citing works
Self-citationNollet, M., Hicks, H., McCarthy, A. P., Wu, H., Möller‐Levet, C. S., Laing, E., Malki, K., Lawless, N., Wafford, K. A., Dijk, D., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816456116 · Cited by 94 · see citing works
Zhang, H., Chaudhury, D., Nectow, A. R., Friedman, A. K., Zhang, S., Juarez, B., Liu, H., Pfau, M. L., Aleyasin, H., Jiang, C., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.020 · Cited by 88 · see citing works
Self-citationWittenberg, G. M., Greene, J., Vértes, P. E., Drevets, W. C., & Bullmore, E. T. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.006 · Cited by 83 · see citing works
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens
Teague, C. D., & Nestler, E. J. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01163-5 · Cited by 80 · see citing works
Self-citationCircuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond
Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 85 · see citing works
Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Zhou, Y., Lutz, P.-E., Wang, Y. C., Ragoussis, J., & Turecki, G. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0267-7 · Cited by 77 · see citing works
“For example, Bagot et al.61 showed that the overexpression of key network “hub genes” led to changes in the expression of a significant number of genes which were enriched with those belonging to the corresponding co-expression network that was related to depression susceptibility in mice.”
Backgroundvan Weert, L. T. C. M., Buurstede, J. C., Mahfouz, A. E., Braakhuis, P. S. M., Polman, J. A. E., Sips, H. C. M., Roozendaal, B., Balog, J., de Kloet, E. R., Datson, N. A., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1422 · Cited by 77 · see citing works
Effect of stress on human biology: Epigenetics, adaptation, inheritance, and social significance
Denhardt, D. T. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25837 · Cited by 76 · see citing works
Vanderplow, A. M., Eagle, A. L., Kermath, B. A., Bjornson, K. J., Robison, A. J., & Cahill, M. E. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.008 · Cited by 74 · see citing works
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 70 · see citing works
Self-citationWeger, M., Alpern, D., Cherix, A., Ghosal, S., Grosse, J., Russeil, J., Rolf Gruetter, A., de Kloet, E. R., Deplancke, B., & Sandi, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-75326-9 · Cited by 71 · see citing works
Multiomic profiling of the acute stress response in the mouse hippocampus
von Ziegler, L., Floriou‐Servou, A., Waag, R., Gupta, R. R. D., Sturman, O., Gapp, K., Maat, C. A., Kockmann, T., Lin, H.-Y., Duss, S. N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29367-5 · Cited by 66 · see citing works
Depression and substance use disorders: Clinical comorbidity and shared neurobiology
Calarco, C. A., & Lobo, M. K. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.004 · Cited by 69 · see citing works
A gene expression atlas for different kinds of stress in the mouse brain
Flati, T., Gioiosa, S., Chillemi, G., Mele, A., Oliverio, A., Mannironi, C., Rinaldi, A., & Castrignanò, T. (2020) · Scientific Data · doi:10.1038/s41597-020-00772-z · Cited by 65 · see citing works
Stress‐Induced Depression: Is Social Rank a Predictive Risk Factor?
Larrieu, T., & Sandi, C. (2018) · BioEssays · doi:10.1002/bies.201800012 · Cited by 61 · see citing works
Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior
Lepack, A. E., Bagot, R. C., Peña, C. J., Loh, Y.-H. E., Farrelly, L. A., Lu, Y., Powell, S. K., Lorsch, Z. S., Issler, O., Cates, H. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608270113 · Cited by 63 · see citing works
Self-citationMolecular Adaptations to Social Defeat Stress and Induced Depression in Mice
Bondar, N. P., Bryzgalov, L. O., Ershov, N., Gusev, F. E., Reshetnikov, V. V., Avgustinovich, D. F., Tenditnik, M. V., Rogaev, E. I., & Merkulova, T. I. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0586-3 · Cited by 60 · see citing works
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice
Rosenberg, A. M., Saggar, M., Monzel, A. S., Devine, J., Rogu, P. J., Limoges, A., Junker, A., Sandi, C., Mosharov, E. V., Dumitriu, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39941-0 · Cited by 60 · see citing works
Genetic insights into the neurobiology of anxiety
Koskinen, M.-K., & Hovatta, I. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.01.007 · Cited by 64 · see citing works
Li, Q., Takeuchi, Y., Wang, J., Gellért, L., Barcsai, L., Pedraza, L. K., Nagy, A. J., Kozák, G., Nakai, S., Kato, S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.013 · Cited by 61 · see citing works
Self-citationTet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors
Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.6 · Cited by 58 · see citing works
Self-citationNasrallah, P., Haidar, E. A., Stephan, J. S., Hayek, L. E., Karnib, N., Khalifeh, M., Barmo, N., Jabre, V., Houbeika, R. Y., Ghanem, A., et al. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100170 · Cited by 57 · see citing works
The long noncoding RNA FEDORA is a cell type– and sex-specific regulator of depression
Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Xia, S.-H., Zinsmaier, A. K., Tan, C., Li, W., Browne, C. J., Walker, D. M., Salery, M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn9494 · Cited by 53 · see citing works
Self-citationNeurobiology of bruxism: The impact of stress (Review)
Pavlou, I., Spandidos, D. A., Zoumpourlis, V., & Papakosta, V. (2024) · Biomedical Reports · doi:10.3892/br.2024.1747 · Cited by 55 · see citing works
Föcking, M., Sabherwal, S., Cates, H. M., Scaife, C., Dicker, P., Hryniewiecka, M., Wynne, K. J., Rutten, B. P. F., Lewis, G., Cannon, M. D., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0306-z · Cited by 54 · see citing works
Self-citationGyles, T. M., Nestler, E. J., & Parise, E. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01625-0 · Cited by 52 · see citing works
Self-citationThe Acute Stress Response in the Multiomic Era
Floriou-Servou, A., von Ziegler, L., Waag, R., Schläppi, C., Germain, P.-L., & Bohacek, J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.031 · Cited by 51 · see citing works
Transcriptome Alterations in Posttraumatic Stress Disorder
Girgenti, M. J., & Duman, R. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.023 · Cited by 51 · see citing works
Huang, P., Gao, T., Dong, Z., Zhou, C., Lai, Y., Pan, T. S., Liu, Y., Zhao, X., Sun, X., Hua, H., et al. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.019 · Cited by 51 · see citing works
Walker, D. M., Zhou, X., Cunningham, A. M., Lipschultz, A. P., Ramakrishnan, A., Cates, H. M., Bagot, R. C., Shen, L., Zhang, B., & Nestler, E. J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.964 · Cited by 51 · see citing works
Self-citationBrivio, P., Audano, M., Gallo, M. T., Gruca, P., Łasoń, M., Litwa, E., Fumagalli, F., Papp, M., Mitro, N., & Calabrese, F. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01856-7 · Cited by 51 · see citing works
Gadd45b mediates depressive-like role through DNA demethylation
Labonté, B., Jeong, Y. H., Parise, E. M., Issler, O., Fatma, M., Engmann, O., Cho, K., Neve, R. L., Nestler, E. J., & Koo, J. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-40844-8 · Cited by 49 · see citing works
Self-citationGumusoglu, S. B., Hing, B. W. Q., Chilukuri, A. S. S., Dewitt, J. J., Scroggins, S. M., & Stevens, H. E. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0640-0 · Cited by 49 · see citing works
Okonogi, T., Kuga, N., Yamakawa, M., Kayama, T., Ikegaya, Y., & Sasaki, T. (2024) · Nature Communications · doi:10.1038/s41467-023-44205-y · Cited by 48 · see citing works
The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers
Larosa, A., & Wong, T. P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110601 · Cited by 47 · see citing works
Histone Modifications in Major Depressive Disorder and Related Rodent Models
Deussing, J. M., & Jakovcevski, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_9 · Cited by 46 · see citing works
Chronic social stress leads to altered sleep homeostasis in mice
Olini, N., Rothfuchs, I., Azzinnari, D., Pryce, C. R., Kurth, S., & Huber, R. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.022 · Cited by 44 · see citing works
Hamilton, P. J., Chen, E. Y., Tolstikov, V., Peña, C. J., Picone, J. A., Shah, P., Panagopoulos, K., Strat, A. N., Walker, D. M., Lorsch, Z. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75114-5 · Cited by 46 · see citing works
Self-citationA diet enriched with curcumin promotes resilience to chronic social defeat stress
Aubry, A., Khandaker, H., Ravenelle, R., Grunfeld, I. S., Bonnefil, V., Chan, K. L., Cathomas, F., Liu, J., Schafe, G. E., & Burghardt, N. S. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0295-2 · Cited by 43 · see citing works
Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
Quessy, F., Bittar, T., Blanchette, L. J., Lévesque, M., & Labonté, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-90521-y · Cited by 42 · see citing works
Yoshino, Y., Roy, B., Kumar, N., Mukhtar, M. S., & Dwivedi, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01159-9 · Cited by 43 · see citing works
Murra, D., Hilde, K. L., Fitzpatrick, A., Maras, P. M., Watson, S. J., & Akil, H. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100437 · Cited by 42 · see citing works
Reshetnikov, V. V., Kisaretova, P. E., Ershov, N., Merkulova, T. I., & Bondar, N. P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110068 · Cited by 40 · see citing works
Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
Mansouri, S., Pessoni, A. M., Marroquín-Rivera, A., Parise, E. M., Tamminga, C. A., Turecki, G., Nestler, E. J., Chen, T., & Labonté, B. (2023) · Nature Communications · doi:10.1038/s41467-023-42686-5 · Cited by 42 · see citing works
Self-citationHervé, M., Bergon, A., Guisquet, A. L., Leman, S., Consoloni, J.-L., Fernandez, N., Lefebvre, M., El‐Hage, W., Belzeaux-R, R., Belzung, C., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00248 · Cited by 40 · see citing works
Cates, H. M., Heller, E. A., Lardner, C. K., Purushothaman, I., Peña, C. J., Walker, D. M., Cahill, M. E., Neve, R. L., Shen, L., Bagot, R. C., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.027 · Cited by 39 · see citing works
Self-citationAltered offspring neurodevelopment in an arginine vasopressin preeclampsia model
Gumusoglu, S. B., Chilukuri, A. S. S., Hing, B. W. Q., Scroggins, S. M., Kundu, S., Sandgren, J. A., Santillan, M. K. O., Santillan, D. A., Grobe, J. L., & Stevens, H. E. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01205-0 · Cited by 39 · see citing works
Sex-specific multi-level 3D genome dynamics in the mouse brain
Rocks, D., Shukla, M., Ouldibbat, L., Finnemann, S. C., Kalluchi, A., Rowley, M. J., & Kundaković, M. (2022) · Nature Communications · doi:10.1038/s41467-022-30961-w · Cited by 39 · see citing works
McCoy, C. R., Glover, M. E., Flynn, L. T., Simmons, R. K., Cohen, J. L., Ptacek, T., Lefkowitz, E. J., Jackson, N. L., Akil, H., Wu, X., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-15.2019 · Cited by 38 · see citing works
Nozaki, K., Ito, H., Ohgidani, M., Yamawaki, Y., Hatice, S. E., Kitajima, T., Katsumata, S., Yamawaki, S., Kato, T. A., & Aizawa, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107835 · Cited by 38 · see citing works
Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stress
Torres‐Berrío, A., Estill, M. S., Patel, V., Ramakrishnan, A., Kronman, H. G., Minier-Toribio, A. M., Issler, O., Browne, C. J., Parise, E. M., van der Zee, Y. Y., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.006 · Cited by 34 · see citing works
Self-citationRegulation of impulsive and aggressive behaviours by a novel lncRNA
Labonté, B., Abdallah, K., Maussion, G., Yerko, V., Yang, J., Bittar, T. P., Quessy, F., Golden, S. A., Navarro-Sánchez, L., Checknita, D., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0637-4 · Cited by 35 · see citing works
Self-citationThe Potential of KCNQ Potassium Channel Openers as Novel Antidepressants
Costi, S., Han, M., & Murrough, J. W. (2022) · CNS Drugs · doi:10.1007/s40263-021-00885-y · Cited by 36 · see citing works
Hughes, B. W., Siemsen, B. M., Tsvetkov, E., Berto, S., Kumar, J., Cornbrooks, R. G., Akiki, R. M., Cho, J. Y., Carter, J. S., Snyder, K. K., et al. (2023) · eLife · doi:10.7554/elife.75631 · Cited by 34 · see citing works
Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens
Pfau, M. L., Purushothaman, I., Feng, J., Golden, S. A., Aleyasin, H., Lorsch, Z. S., Cates, H. M., Flanigan, M. E., Ménard, C., Heshmati, M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00144 · Cited by 35 · see citing works
Self-citationStress and Its Impact on the Transcriptome
Girgenti, M. J., Pothula, S., & Newton, S. S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.011 · Cited by 35 · see citing works
Sex-Specific Effects of Stress on Mood-Related Gene Expression
Barko, K., Paden, W., Cahill, K. M., Seney, M. L., & Logan, R. W. (2019) · Complex Psychiatry · doi:10.1159/000499105 · Cited by 34 · see citing works
Louwies, T., & Meerveld, B. G. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13751 · Cited by 33 · see citing works
Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area
Campbell, R. R., Chen, S., Beardwood, J. H., López, A. J., Pham, L. V., Keiser, A. A., Childs, J. E., Matheos, D. P., Swarup, V., Baldi, P., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01031-4 · Cited by 33 · see citing works
Translational models of stress and resilience: An applied neuroscience methodology review
Albayrak, Z. S., Vaz, A., Bordes, J., Ünlü, S., Sep, M. S. C., Vinkers, C. H., Pinto, L., & Eser, H. Y. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104064 · Cited by 39 · see citing works
Zhukovskaya, A., Zimmerman, C. A., Willmore, L., Pan-Vazquez, A., Janarthanan, S. R., Lynch, L. A., Falkner, A. L., & Witten, I. B. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.009 · Cited by 32 · see citing works
- Authors
- Bagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., Heller, E. A., Issler, O., Wang, M., Song, W.-M., Stein, J. L., Liu, X., Doyle, M. A., Scobie, K. N., Sun, H. S., Neve, R. L., Geschwind, D., Dong, Y., Shen, L., Zhang, B., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Pittsburgh (US)
- University of Pennsylvania (US)
- University of North Carolina at Chapel Hill (US)
- Massachusetts Institute of Technology (US)
- University of California, Los Angeles (US)
- Corresponding author
- Shen, Li
- Zhang, Bin
- Nestler, Eric J.
- ORCID
- Bagot, Rosemary C.
- Cates, Hannah M.
- Lorsch, Zachary S.
- Walker, Deena M.
- Wang, Junshi
- Huang, Xiaojie
- Schlüter, Oliver M.
- Maze, Ian
- Peña, Catherine J.
- Heller, Elizabeth A.
- Issler, Orna
- Wang, Minghui
- Stein, Jason. L.
- Liu, Xiaochuan
- Doyle, Marie A.
- Neve, Rachael L.
- Geschwind, Daniel
- Dong, Yan
- Shen, Li
- Zhang, Bin
- Nestler, Eric J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 90
- Issue
- 5
- Pages
- 969-983
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4896746
- OpenAlex
- W2353111961
- Cited by
- 333
- References
- 69
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 37 · 2023: 33 · 2022: 33 · 2021: 47 · 2020: 30 · 2019: 34 · 2018: 34 · 2017: 24 · 2016: 4
- FWCI
- 25.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, other-oa)
- UNC Libraries
- Funders
- National Alliance for Research on Schizophrenia and Depression
- MQ: Transforming Mental Health (MQ15FIP100011)
- National Institutes of Health
- National Institute on Aging (U01AG046170)
- National Institute of Mental Health (P50MH096890, R01MH051399)
- National Institute on Drug Abuse (R01DA030379, T32DA007135, R01DA034856, R01DA040620, R37DA023206)
- National Institute of Allergy and Infectious Diseases (U01AI111598)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, chronic social defeat stress, depression vulnerability, transcriptional regulatory networks, driver genes, stress resilience, synaptic regulation, antidepressant drug discovery, circuit function
- MeSH terms
- Animals, Brain, Depression, Hippocampus, Neural Pathways, Social Behavior, Excitatory Postsynaptic Potentials, Genetic Predisposition to Disease, Mice, Gene Regulatory Networks, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
