Wheeler, Michael B.

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 917

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

MacDonald, P. E., El-kholy, W., Riedel, M. J., Salapatek, A. M. F., Light, P. E., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 590

Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion

Chan, C. B., De Leo, D., Joseph, J. W., McQuaid, T. S., Ha, X. F., Xu, F., Tsushima, R. G., Pennefather, P. S., Salapatek, A. M. F., & Wheeler, M. B. (2001) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 341

Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells

Kang, G., Joseph, J. W., Chepurny, O. G., Monaco, M., Wheeler, M. B., Bos, J. L., Schwede, F., Genieser, H.-G., & Holz, G. G. (2003) · Journal of Biological Chemistry

Pancreatic function and diabetesCalcium signaling and nucleotide metabolism

Cited by 298

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Xu, E., Kumar, M., Zhang, Y., Ju, W., Obata, T., Zhang, N., Liu, S., Wendt, A., Deng, S., Ebina, Y., et al. (2006) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 283

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan, C. B., MacDonald, P. E., Saleh, M. C., Johns, D. C., Marbàn, E., & Wheeler, M. B. (1999) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 242

Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion*

Wijesekara, N., Krishnamurthy, M., Bhattacharjee, A., Suhail, A., Sweeney, G., & Wheeler, M. B. (2010) · Journal of Biological Chemistry

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 229

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

Wheeler, M. B., Lu, M., Dillon, J. S., Leng, X. H., Chen, C., & Boyd, A. E. (1993) · Endocrinology

Pancreatic function and diabetesReceptor Mechanisms and Signaling

Cited by 225

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 220

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells

MacLellan, J. D., Gerrits, M. F., Gowing, A., Smith, P. J. S., Wheeler, M. B., & Harper, M.-E. (2005) · Diabetes

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 213

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 206

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

Lu, M., Wheeler, M. B., Leng, X. H., & Boyd, A. E. (1993) · Endocrinology

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 151

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Robson-Doucette, C. A., Sultan, S., Allister, E. M., Wikstrom, J. D., Koshkin, V., Bhattacharjee, A., Prentice, K. J., Sereda, S. B., Shirihai, O. S., & Wheeler, M. B. (2011) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 136

Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties.

Wheeler, M. B., Gelling, R. W., McIntosh, C. H., Georgiou, J., Brown, J. C., & Pederson, R. A. (1995) · Endocrinology

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 130

Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids.

Koshkin, V., Wang, X., Scherer, P. E., Chan, C. B., & Wheeler, M. B. (2003) · Journal of Biological Chemistry

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 121

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K+ Currents in β-Cells

MacDonald, P. E., Salapatek, A. M. F., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesIon channel regulation and function

Cited by 103

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Singh, I., Wang, L., Xia, B., Liu, J., Tahiri, A., El Ouaamari, A., Wheeler, M. B., & Pang, Z. P. (2022) · Cell & Bioscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 98

Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth

Zhu, D., Zhang, Y., Lam, P. P. L., Dolai, S., Liu, Y., Cai, E. P., Choi, D., Schroer, S. A., Kang, Y., Allister, E. M., et al. (2012) · Cell Metabolism

Pancreatic function and diabetesCellular transport and secretion

Cited by 87

Synaptosome-Associated Protein of 25 Kilodaltons Modulates Kv2.1 Voltage-Dependent K+ Channels in Neuroendocrine Islet β-Cells through an Interaction with the Channel N Terminus

MacDonald, P. E., Wang, G., Tsuk, S., Dodo, C., Kang, Y., Tang, L., Wheeler, M. B., Cattral, M. S., Lakey, J. R. T., Salapatek, A. M. F., et al. (2002) · Molecular Endocrinology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 78

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

Mathi, S. K., Chan, Y., Li, X., & Wheeler, M. B. (1997) · Molecular Endocrinology

Receptor Mechanisms and SignalingPancreatic function and diabetes

Cited by 71

Oscillatory Membrane Potential Response to Glucose in Islet β-Cells: A Comparison of Islet-Cell Electrical Activity in Mouse and Rat

Manning Fox, J. E., Gyulkhandanyan, A. V., Satin, L. S., & Wheeler, M. B. (2006) · Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 70

Glutathionylation State of Uncoupling Protein-2 and the Control of Glucose-stimulated Insulin Secretion

Mailloux, R. J., Fu, A., Robson-Doucette, C., Allister, E. M., Wheeler, M. B., Screaton, R., & Harper, M.-E. (2012) · Journal of Biological Chemistry

Pancreatic function and diabetesRedox biology and oxidative stress

Cited by 66

Characterization of Erg K+ Channels in α- and β-Cells of Mouse and Human Islets

Hardy, A. B., Fox, J. E. M., Giglou, P. R., Wijesekara, N., Bhattacharjee, A., Sultan, S., Gyulkhandanyan, A. V., Gaisano, H. Y., MacDonald, P. E., & Wheeler, M. B. (2009) · Journal of Biological Chemistry

Pancreatic function and diabetesIon channel regulation and function

Cited by 54

Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study

Zhang, Z., Lai, M., Piro, A. L., Alexeeff, S. E., Allalou, A., Röst, H. L., Dai, F. F., Wheeler, M. B., & Gunderson, E. P. (2021) · BMC Medicine

Breastfeeding Practices and InfluencesGestational Diabetes Research and Management

Cited by 34