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β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

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Mitochondrial proton leaks and uncoupling proteins

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Production of Reactive Oxygen Species in the Diabetic Heart

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Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

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The efficiency of cellular energy transduction and its implications for obesity

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Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes

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Uncoupling protein-2 regulates lifespan in mice

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Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

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Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis

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Mitochondrial dysfunction in pancreatic β-cells in Type 2 Diabetes

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β-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels

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Mitochondrial regulation of β-cell function: Maintaining the momentum for insulin release

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Uncoupling proteins, dietary fat and the metabolic syndrome

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Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes

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The −866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes

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Type 2 diabetes mellitus: not quite exciting enough?

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Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes

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Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients

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Uncoupling proteins in the mitochondrial defense against oxidative stress

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Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

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Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo

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Ghrelin and lipid metabolism: key partners in energy balance

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Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production

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The pathogenetic role of β-cell mitochondria in type 2 diabetes

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Inhibition of UCP2 expression reverses diet‐induced diabetes mellitus by effects on both insulin secretion and action

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Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

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Glucolipotoxicity in Pancreatic β-Cells

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Uncoupling protein 2 and metabolic diseases

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Neuroprotective Role of Mitochondrial Uncoupling Protein 2 in Cerebral Stroke

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Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose-Stimulated Insulin Secretion in a β-Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element-Binding Protein-1c

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Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane

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On the role of uncoupling protein-2 in pancreatic beta cells

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Limited Mitochondrial Permeabilization Is an Early Manifestation of Palmitate-induced Lipotoxicity in Pancreatic β-Cells

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Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

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Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

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Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

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IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1

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Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

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UCP2 is highly expressed in pancreatic α-cells and influences secretion and survival

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Uncoupling Proteins: Role in Insulin Resistance and Insulin Insufficiency

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Insulin Resistance, Obesity, and Lipotoxicity

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The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet

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Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

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Uncoupling proteins: A complex journey to function discovery

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Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation

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Muscle-Specific Overexpression of CD36 Reverses the Insulin Resistance and Diabetes of MKR Mice

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RIPK3-mediated inflammation is a conserved β cell response to ER stress

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Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?

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Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic β-Cells

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Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging

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Gαz Negatively Regulates Insulin Secretion and Glucose Clearance

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Beta-cell stimulus-secretion coupling: a role for uncoupling protein 2

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

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UCP2, Insulin, and Type 2 Diabetes

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The effect of uncoupling protein 2 on proinsulin processing

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The role of uncoupling protein 2 in the development of type 2 diabetes

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