Schymkowitz, Joost

The FoldX web server: an online force field

Schymkowitz, J., Borg, J., Stricher, F., Nys, R., Rousseau, F., & Serrano, L. (2005) · Nucleic Acids Research

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,759

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Xu, J., Reumers, J., Couceiro, J. R., De Smet, F., Gallardo, R., Rudyak, S., Cornelis, A., Rozenski, J., Zwolinska, A., Marine, J.-C., et al. (2011) · Nature Chemical Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 543

Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Kuperstein, I., Broersen, K., Benilova, I., Rozenski, J., Jonckheere, W., Debulpaep, M., Vandersteen, A., Segers‐Nolten, I., Van Der Werf, K., Subramaniam, V., et al. (2010) · The EMBO Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 532

The mechanism of γ‐Secretase dysfunction in familial Alzheimer disease

Chávez‐Gutiérrez, L., Bammens, L., Benilova, I., Vandersteen, A., Benurwar, M., Borgers, M., Lismont, S., Zhou, L., Van Cleynenbreugel, S., Esselmann, H., et al. (2012) · The EMBO Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 495

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD

Boeynaems, S., Bogaert, E., Michiels, E., Gijselinck, I., Sieben, A., Jovičić, A., De Baets, G., Scheveneels, W., Steyaert, J., Cuijt, I., et al. (2016) · Scientific Reports

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 262

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease

Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., Schymkowitz, J., Rousseau, F., Pastore, A., Serpell, L. C., et al. (2012) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 253

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

Szaruga, M., Munteanu, B., Lismont, S., Veugelen, S., Horré, K., Mercken, M., Saido, T. C., Ryan, N. S., De Vos, T., Savvides, S. N., et al. (2017) · Cell

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 248

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

Broersen, K., Rousseau, F., & Schymkowitz, J. (2010) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 168

Progranulin genetic variability contributes to amyotrophic lateral sclerosis

Sleegers, K., Brouwers, N., Maurer-Stroh, S., van Es, M. A., Damme, P. V., van Vught, P. W. J., van der Zee, J., Serneels, S., Pooter, T. D., Van den Broeck, M., et al. (2008) · Neurology

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 161

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Liu, S., Hossinger, A., Heumüller, S.-E., Hornberger, A., Buravlova, O., Konstantoulea, K., Müller, S. A., Paulsen, L., Rousseau, F., Schymkowitz, J., et al. (2021) · Nature Communications

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 72

N-glycosylation as a eukaryotic protective mechanism against protein aggregation

Duran-Romaña, R., Houben, B., De Vleeschouwer, M., Louros, N., Wilson, M. P., Matthijs, G., Schymkowitz, J., & Rousseau, F. (2024) · Science Advances

Glycosylation and Glycoproteins ResearchHeat shock proteins research

Cited by 52

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Louros, N., Ramakers, M., Michiels, E., Konstantoulea, K., Morelli, C., Garcia, T., Moonen, N., D’Haeyer, S., Goossens, V., Thal, D. R., et al. (2022) · Nature Communications

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 28

Analyzing the implications of protein folding delay caused by translation

Houben, B., Duran-Romaña, R., Migens, P. F., Rousseau, F., & Schymkowitz, J. (2024) · Nature Communications

Heat shock proteins researchRNA and protein synthesis mechanisms

Cited by 10

De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder

Sleyp, Y., Valenzuela, I., Accogli, A., Ballon, K., Ben-Zeev, B., Berkovic, S. F., Broly, M., Callaerts, P., Caylor, R. C., Charles, P., et al. (2022) · Genetics in Medicine

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 10

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein

Janssen, K., Claes, F., Van de Velde, D., Wehbi, V. L., Houben, B., Lampi, Y., Nys, M., Khodaparast, L., Khodaparast, L., Louros, N., et al. (2023) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis

Cited by 10

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

Duran-Romaña, R., Houben, B., Migens, P. F., Zhang, Y., Rousseau, F., & Schymkowitz, J. (2025) · Nature Communications

Heat shock proteins researchRNA and protein synthesis mechanisms

Cited by 10

Integrating physics in deep learning algorithms: A force field as a PyTorch module

Orlando, G., Serrano, L., Schymkowitz, J., & Rousseau, F. (2023) · Bioinformatics

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 7

Integrating physics in deep learning algorithms: a force field as a PyTorch module

Orlando, G., Serrano, L., Schymkowitz, J., & Rousseau, F. (2024) · Bioinformatics

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 7