Freathy, Rachel M.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 9,442

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 4,531

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 2,194

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,864

Common variants near MC4R are associated with fat mass, weight and risk of obesity

The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics

Genetic Associations and EpidemiologyRegulation of Appetite and Obesity

Cited by 1,325

Genome-wide association analysis identifies 20 loci that influence adult height

Initiative, D. G., Weedon, M. N., The Wellcome Trust Case Control Consortium, Cambridge GEM Consortium, Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., et al. (2008) · Nature Genetics

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 826

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones, S. E., Lane, J. M., Wood, A. R., van Hees, V. T., Tyrrell, J., Beaumont, R. N., Jeffries, A. R., Dashti, H. S., Hillsdon, M., Ruth, K. S., et al. (2019) · Nature Communications

Circadian rhythm and melatoninGenetic Associations and Epidemiology

Cited by 691

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

Jones, S. E., Tyrrell, J., Wood, A. R., Beaumont, R. N., Ruth, K. S., Tuke, M. A., Yaghootkar, H., Hu, Y., Teder-Laving, M., Hayward, C., et al. (2016) · PLOS Genetics

Circadian rhythm and melatoninGenetic Associations and Epidemiology

Cited by 388

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank

Tyrrell, J., Jones, S. E., Beaumont, R., Astley, C. M., Lovell, R., Yaghootkar, H., Tuke, M., Ruth, K. S., Freathy, R. M., Hirschhorn, J. N., et al. (2016) · BMJ

Genetic Associations and EpidemiologyIntergenerational and Educational Inequality Studies

Cited by 372

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

Jones, S. E., van Hees, V. T., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., van der Spek, A., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2019) · Nature Communications

Sleep and related disordersGenetic Associations and Epidemiology

Cited by 300

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., et al. (2016) · JAMA

Birth, Development, and HealthGestational Diabetes Research and Management

Cited by 284

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

Medici, M., Porcu, E., Pistis, G., Teumer, A., Brown, S. J., Jensen, R. A., Rawal, R., Roef, G. L., Plantinga, T. S., Vermeulen, S. H., et al. (2014) · PLoS Genetics

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 218

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

Frayling, T. M., Beaumont, R. N., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J., Sharp, S., et al. (2018) · Cell Reports

Fibroblast Growth Factor ResearchGenetic Associations and Epidemiology

Cited by 101

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively

The GIANT consortium, Wood, A. R., Tyrrell, J., Beaumont, R., Jones, S. E., Tuke, M. A., Ruth, K. S., Yaghootkar, H., Freathy, R. M., Murray, A., et al. (2016) · Diabetologia

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 74

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health

Ruth, K. S., Beaumont, R. N., Tyrrell, J., Jones, S. E., Tuke, M. A., Yaghootkar, H., Wood, A. R., Freathy, R. M., Weedon, M. N., Frayling, T. M., et al. (2016) · Human Reproduction

Hypothalamic control of reproductive hormonesReproductive Biology and Fertility

Cited by 70

Smoking Is Associated with, but Does Not Cause, Depressed Mood in Pregnancy – A Mendelian Randomization Study

Lewis, S. J., Araya, R., Davey Smith, G., Freathy, R., Gunnell, D., Palmer, T., & Munafò, M. (2011) · PLoS ONE

Smoking Behavior and CessationGenetic Associations and Epidemiology

Cited by 53

Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health

O’Loughlin, J., Casanova, F., Jones, S. E., Hagenaars, S. P., Beaumont, R. N., Freathy, R. M., Watkins, E. R., Vetter, C., Rutter, M. K., Cain, S. W., et al. (2021) · Molecular Psychiatry

Circadian rhythm and melatoninSleep and related disorders

Cited by 44

Phosphodiesterase 8B Gene Polymorphism Is Associated with Subclinical Hypothyroidism in Pregnancy

Shields, B. M., Freathy, R. M., Knight, B. A., Hill, A., Weedon, M. N., Frayling, T. M., Hattersley, A. T., & Vaidya, B. (2009) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 35

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

Jones, S. E., Hees, V. T. V., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., der Spek, A. V., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

Sleep and related disordersGenetic Associations and Epidemiology

Cited by 14