Nishimasu, Hiroshi

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 2,825

Crystal structure of Cas9 in complex with guide RNA and target DNA

Nishimasu, H., Ran, F. A., Hsu, P. D., Konermann, S., Shehata, S. I., Dohmae, N., Ishitani, R., Zhang, F., & Nureki, O. (2014) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,306

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nishimasu, H., Shi, X., Ishiguro, S., Gao, L., Hirano, S., Okazaki, S., Noda, T., Abudayyeh, O. O., Gootenberg, J. S., Mori, H., et al. (2018) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,100

Engineered Cpf1 variants with altered PAM specificities

Gao, L., Cox, D. B. T., Yan, W. X., Manteiga, J. C., Schneider, M. W., Yamano, T., Nishimasu, H., Nureki, O., Crosetto, N., & Zhang, F. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 460

Bridge RNAs direct programmable recombination of target and donor DNA

Durrant, M. G., Perry, N. T., Pai, J. J., Jangid, A. R., Athukoralage, J. S., Hiraizumi, M., McSpedon, J. P., Pawluk, A., Nishimasu, H., Konermann, S., et al. (2024) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 163

Structural basis for the altered PAM specificities of engineered CRISPR-cas9

Hirano, S., Nishimasu, H., Ishitani, R., & Nureki, O. (2016) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 152

Structural basis for the altered PAM recognition by engineered CRISPR-Cpf1

Nishimasu, H., Yamano, T., Gao, L., Zhang, F., Ishitani, R., & Nureki, O. (2017) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 102

Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation

Omura, S. N., Nakagawa, R., Kajimoto, S., Okazaki, S., Ishiguro, S., Mori, H., Onishi, K., Kashiwakura, Y., Hiramoto, T., Horinaka, K., et al. (2026) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2