Verdine, Gregory L.

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Verdine, G. L., & Korsmeyer, S. J. (2004) · Science

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 1,349

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

Schafmeister, C. E., Po, J., & Verdine, G. L. (2000) · Journal of the American Chemical Society

Chemical Synthesis and AnalysisBiochemical and Structural Characterization

Cited by 1,037

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

Bruner, S. D., Norman, D. P. G., & Verdine, G. L. (2000) · Nature

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 972

Direct inhibition of the NOTCH transcription factor complex

Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature

Chemical Synthesis and AnalysisRNA Interference and Gene Delivery

Cited by 752

Stapled Peptides for Intracellular Drug Targets

Verdine, G. L., & Hilinski, G. J. (2012) · Methods in Enzymology

Chemical Synthesis and AnalysisBiochemical and Structural Characterization

Cited by 433

A Stapled BID BH3 Helix Directly Binds and Activates BAX

Walensky, L. D., Pitter, K., Morash, J., Oh, K. J., Barbuto, S., Fisher, J., Smith, E., Verdine, G. L., & Korsmeyer, S. J. (2006) · Molecular Cell

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 383

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Kim, Y.-W., Grossmann, T. N., & Verdine, G. L. (2011) · Nature Protocols

Chemical Synthesis and AnalysisSynthetic Organic Chemistry Methods

Cited by 376

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Banerjee, A., Yang, W., Karplus, M., & Verdine, G. L. (2005) · Nature

DNA Repair MechanismsEnzyme Structure and Function

Cited by 346

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Grossmann, T. N., Yeh, J. T.-H., Bowman, B. R., Chu, Q., Moellering, R. E., & Verdine, G. L. (2012) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerChemical Synthesis and Analysis

Cited by 268

Structure of the Stapled p53 Peptide Bound to Mdm2

Baek, S., Kutchukian, P. S., Verdine, G. L., Huber, R., Holak, T. A., Lee, K. W., & Popowicz, G. M. (2012) · Journal of the American Chemical Society

Cancer-related Molecular PathwaysChemical Synthesis and Analysis

Cited by 259

Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

Shigdel, U. K., Lee, S.-J., Sowa, M. E., Bowman, B. R., Robison, K., Zhou, M., Pua, K. H., Stiles, D. T., Blodgett, J. A. V., Udwary, D. W., et al. (2020) · Proceedings of the National Academy of Sciences

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 80

Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations

Radom, C. T., Banerjee, A., & Verdine, G. L. (2007) · Journal of Biological Chemistry

DNA Repair MechanismsEnzyme Structure and Function

Cited by 75

Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp

Chen, L., Oakley, M. G., Mark Glover, J. N., Jain, J., B. Dervan, P., Hogan, P. G., Rao, A., & Verdine, G. L. (1995) · Current Biology

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 64

A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex

Banerjee, A., & Verdine, G. L. (2006) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 48