Darnell, Robert B.

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 2,072

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature

MicroRNA in disease regulationRNA Research and Splicing

Cited by 1,791

De Novo Gene Disruptions in Children on the Autistic Spectrum

Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y.-H., Narzisi, G., Leotta, A., et al. (2012) · Neuron

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 1,446

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature

RNA Research and SplicingRNA regulation and disease

Cited by 1,352

A call for transparent reporting to optimize the predictive value of preclinical research

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 1,196

CLIP Identifies Nova-Regulated RNA Networks in the Brain

Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science

RNA Research and SplicingRNA regulation and disease

Cited by 1,120

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 1,109

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell

Genetics and Neurodevelopmental DisordersRNA Research and Splicing

Cited by 952

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 766

Vaccine Breakthrough Infections with SARS-CoV-2 Variants

Hacisuleyman, E., Hale, C., Saito, Y., Blachere, N. E., Bergh, M., Conlon, E. G., Schaefer-Babajew, D. J., DaSilva, J., Muecksch, F., Gaebler, C., et al. (2021) · New England Journal of Medicine

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 716

Nova regulates brain-specific splicing to shape the synapse

Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., et al. (2005) · Nature Genetics

RNA Research and SplicingRNA regulation and disease

Cited by 509

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., Yang, Y. Y. L., & Darnell, R. B. (2000) · Neuron

RNA Research and SplicingRNA regulation and disease

Cited by 426

HITS-CLIP: panoramic views of protein-RNA regulation in living cells

Darnell, R. B. (2010) · WIREs RNA

RNA Research and SplicingCancer-related molecular mechanisms research

Cited by 382

A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons

Okano, H. J., & Darnell, R. B. (1997) · The Journal of Neuroscience

RNA Research and SplicingNeuroscience and Neuropharmacology Research

Cited by 379

HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism

Weyn-Vanhentenryck, S. M., Mele, A., Yan, Q., Sun, S., Farny, N., Zhang, Z., Xue, C., Herre, M., Silver, P. A., Zhang, M. Q., et al. (2014) · Cell Reports

RNA Research and SplicingGenetics and Neurodevelopmental Disorders

Cited by 333

An alternative mode of microRNA target recognition

Chi, S. W., Hannon, G. J., & Darnell, R. B. (2012) · Nature Structural & Molecular Biology

MicroRNA in disease regulationRNA Research and Splicing

Cited by 328

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 326

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

Loeb, G. B., Khan, A. A., Canner, D., Hiatt, J. B., Shendure, J., Darnell, R. B., Leslie, C. S., & Rudensky, A. Y. (2012) · Molecular Cell

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 311

Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls

Zhang, C., Frias, M. A., Mele, A., Ruggiu, M., Eom, T., Marney, C. B., Wang, H., Licatalosi, D. D., Fak, J. J., & Darnell, R. B. (2010) · Science

RNA Research and SplicingRNA regulation and disease

Cited by 294

Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes

Darnell, J. C., Fraser, C. E., Mostovetsky, O., Stefani, G., Jones, T. A., Eddy, S. R., & Darnell, R. B. (2005) · Genes & Development

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 287

Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells

Stefani, G., Fraser, C. E., Darnell, J. C., & Darnell, R. B. (2004) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 274

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

Moore, M. J., Zhang, C., Gantman, E. C., Mele, A., Darnell, J. C., & Darnell, R. B. (2014) · Nature Protocols

RNA Research and SplicingRNA regulation and disease

Cited by 251

The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia

Yang, Y. Y. L., Yin, G. L., & Darnell, R. B. (1998) · Proceedings of the National Academy of Sciences

Autoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and Disorders

Cited by 219

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability

Ince-Dunn, G., Okano, H. J., Jensen, K. B., Park, W.-Y., Zhong, R., Ule, J., Mele, A., Fak, J. J., Yang, C., Zhang, C., et al. (2012) · Neuron

RNA Research and SplicingNeuroscience and Neuropharmacology Research

Cited by 212