Darnell, Robert B.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

Licatalosi, D. D., Yano, M., Fak, J. J., Mele, A., Grabinski, S. E., Zhang, C., & Darnell, R. B. (2012) · Genes & Development

RNA Research and SplicingNeurogenesis and neuroplasticity mechanisms

Cited by 193

RNA Protein Interaction in Neurons

Darnell, R. B. (2013) · Annual Review of Neuroscience

RNA Research and SplicingNeuroscience and Neuropharmacology Research

Cited by 181

Nova2 Regulates Neuronal Migration through an RNA Switch in Disabled-1 Signaling

Yano, M., Hayakawa-Yano, Y., Mele, A., & Darnell, R. B. (2010) · Neuron

Neurogenesis and neuroplasticity mechanismsRNA Research and Splicing

Cited by 176

Common Molecular Pathways Mediate Long-Term Potentiation of Synaptic Excitation and Slow Synaptic Inhibition

Huang, C. S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L. A., Darnell, R. B., Jan, Y. N., & Jan, L. Y. (2005) · Cell

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 157

Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

Scheckel, C., Drapeau, E., Frias, M. A., Park, C. Y., Fak, J., Zucker-Scharff, I., Kou, Y., Haroutunian, V., Ma'ayan, A., Buxbaum, J. D., et al. (2016) · eLife

RNA Research and SplicingRNA regulation and disease

Cited by 139

A mouse model of the human Fragile X syndrome I304N mutation

Zang, J. B., Nosyreva, E. D., Spencer, C. M., Volk, L. J., Musunuru, K., Zhong, R., Stone, E. F., Yuva-Paylor, L. A., Huber, K. M., Paylor, R., et al. (2009) · PLoS Genetics

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 138

Nova autoregulation reveals dual functions in neuronal splicing

Dredge, B. K., Stefani, G., Engelhard, C. C., & Darnell, R. B. (2005) · The EMBO Journal

RNA Research and SplicingRNA regulation and disease

Cited by 125

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

Eom, T., Zhang, C., Wang, H., Lay, K., Fak, J., Noebels, J. L., & Darnell, R. B. (2013) · eLife

RNA Research and SplicingEpilepsy research and treatment

Cited by 118

Rescuing Z + agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing

Ruggiu, M., Herbst, R., Kim, N., Jevsek, M., Fak, J. J., Mann, M. A., Fischbach, G., Burden, S. J., & Darnell, R. B. (2009) · Proceedings of the National Academy of Sciences

RNA Research and SplicingAmyotrophic Lateral Sclerosis Research

Cited by 113

Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer

Luna, J. M., Barajas, J. M., Teng, K.-Y., Sun, H.-L., Moore, M. J., Rice, C. M., Darnell, R. B., & Ghoshal, K. (2017) · Molecular Cell

MicroRNA in disease regulationCancer-related molecular mechanisms research

Cited by 80

cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation

Hwang, H.-W., Saito, Y., Park, C. Y., Blachère, N. E., Tajima, Y., Fak, J. J., Zucker-Scharff, I., & Darnell, R. B. (2017) · Neuron

RNA Research and SplicingRNA regulation and disease

Cited by 74

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

Kwart, D., Gregg, A., Scheckel, C., Murphy, E. A., Paquet, D., Duffield, M., Fak, J., Olsen, O., Darnell, R. B., & Tessier-Lavigne, M. (2019) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 70

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

Leggere, J. C., Saito, Y., Darnell, R. B., Tessier-Lavigne, M., Junge, H. J., & Chen, Z. (2016) · eLife

Axon Guidance and Neuronal SignalingRNA Research and Splicing

Cited by 67

The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels

Allen, S. E., Darnell, R. B., & Lipscombe, D. (2010) · Channels

RNA Research and SplicingIon channel regulation and function

Cited by 48