Lachin, John M.

Randomization in clinical trials: Conclusions and recommendations

Lachin, J. M., Matts, J. P., & Wei, L. J. (1988) · Controlled Clinical Trials

Statistical Methods in Clinical TrialsOptimal Experimental Design Methods

Cited by 272

Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT

Kahn, S. E., Lachin, J. M., Zinman, B., Haffner, S. M., Aftring, R. P., Paul, G., Kravitz, B. G., Herman, W. H., Viberti, G., Holman, R. R., et al. (2011) · Diabetes

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 249

Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrum of heart failure risk in the EMPA-REG OUTCOME® trial

Fitchett, D., Butler, J., van de Borne, P., Zinman, B., Lachin, J. M., Wanner, C., Woerle, H. J., Hantel, S., George, J. T., Johansen, O. E., et al. (2018) · European Heart Journal

Diabetes Treatment and ManagementHeart Failure Treatment and Management

Cited by 242

Risk factors for diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study

Braffett, B. H., Gubitosi-Klug, R. A., Albers, J. W., Feldman, E. L., Martin, C. L., White, N. H., Orchard, T. J., Lopes-Virella, M., Lachin, J. M., Pop-Busui, R., et al. (2020) · Diabetes

Diabetes Management and ResearchPeripheral Neuropathies and Disorders

Cited by 221

Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Clinical Trial

McGuire, D. K., Van de Werf, F., Armstrong, P. W., Standl, E., Koglin, J., Green, J. B., Bethel, M. A., Cornel, J. H., Lopes, R. D., Halvorsen, S., et al. (2016) · JAMA Cardiology

Diabetes Treatment and ManagementHeart Failure Treatment and Management

Cited by 217

Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy, and cardiovascular outcomes in the DCCT/EDIC study

Nathan, D. M., McGee, P., Steffes, M. W., Lachin, J. M., & the DCCT/EDIC Research Group (2014) · Diabetes

Diabetes Management and ResearchAdvanced Glycation End Products research

Cited by 214

Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA ® )

Marx, N., Rosenstock, J., Kahn, S. E., Zinman, B., Kastelein, J. J., Lachin, J. M., Espeland, M. A., Bluhmki, E., Mattheus, M., Ryckaert, B., et al. (2015) · Diabetes and Vascular Disease Research

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 212

Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study

Lachin, J. M., Orchard, T. J., Nathan, D. M., & for the DCCT/EDIC Research Group (2014) · Diabetes Care

Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 206

Impact of insulin and metformin versus metformin alone on β-cell function in youth with impaired glucose tolerance or recently diagnosed type 2 diabetes

The RISE Consortium, Nadeau, K. J., Hannon, T. S., Edelstein, S. L., Arslanian, S. A., Caprio, S., Leschek, E. W., Zeitler, P. S., Buchanan, T. A., Ehrmann, D. A., et al. (2018) · Diabetes Care

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 176

Association of diet with glycated hemoglobin during intensive treatment of type 1 diabetes in the Diabetes Control and Complications Trial

Delahanty, L. M., Nathan, D. M., Lachin, J. M., Hu, F. B., Cleary, P. A., Ziegler, G. K., Wylie-Rosett, J., & Wexler, D. J. (2009) · The American Journal of Clinical Nutrition

Diabetes Management and ResearchNutritional Studies and Diet

Cited by 152

Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes

Genuth, S., Sun, W., Cleary, P., Gao, X., Sell, D. R., Lachin, J., The DCCT/EDIC Research Group, & Monnier, V. M. (2015) · Diabetes

Advanced Glycation End Products researchDiabetes Management and Research

Cited by 146

Cognitive performance declines in older adults with type 1 diabetes: results from 32 years of follow-up in the DCCT and EDIC Study

Jacobson, A. M., Ryan, C. M., Braffett, B. H., Gubitosi-Klug, R. A., Lorenzi, G. M., Luchsinger, J. A., Trapani, V. R., Bebu, I., Chaytor, N., Hitt, S. M., et al. (2021) · The Lancet Diabetes & Endocrinology

Diabetes Management and ResearchDementia and Cognitive Impairment Research

Cited by 138

Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk

Zinman, B., Inzucchi, S. E., Lachin, J. M., Wanner, C., Fitchett, D., Kohler, S., Mattheus, M., Woerle, H. J., Broedl, U. C., Johansen, O. E., et al. (2017) · Stroke

Diabetes Treatment and ManagementAcute Ischemic Stroke Management

Cited by 136

Long-term effects of metformin on diabetes prevention: identification of subgroups that benefited most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study

Diabetes Prevention Program Research Group, Nathan, D. M., Knowler, W. C., Edelstein, S., Crandall, J. P., Dabelea, D., Goldberg, R. B., Kahn, S. E., Mather, K. J., Trandafirescu, G., et al. (2019) · Diabetes Care

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 128

Albuminuria changes and cardiovascular and renal outcomes in type 1 diabetes: the DCCT/EDIC study

de Boer, I. H., Gao, X., Cleary, P. A., Bebu, I., Lachin, J. M., Molitch, M. E., Orchard, T., Paterson, A. D., Perkins, B. A., Steffes, M. W., et al. (2016) · Clinical Journal of the American Society of Nephrology

Chronic Kidney Disease and DiabetesDiabetes Management and Research

Cited by 114

Factors associated with diabetes onset during metformin versus placebo therapy in the Diabetes Prevention Program

Lachin, J. M., Christophi, C. A., Edelstein, S. L., Ehrmann, D. A., Hamman, R. F., Kahn, S. E., Knowler, W. C., Nathan, D. M., & on behalf of the DPP Research Group (2007) · Diabetes

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 107

Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia

Gubitosi-Klug, R. A., Braffett, B. H., Hitt, S., Arends, V., Uschner, D., Jones, K., Diminick, L., Karger, A. B., Paterson, A. D., Roshandel, D., et al. (2021) · Journal of Clinical Investigation

Diabetes and associated disordersDiabetes Management and Research

Cited by 86

Mediators of the improvement in heart failure outcomes with empagliflozin in the EMPA-REG OUTCOME trial

Fitchett, D., Inzucchi, S. E., Zinman, B., Wanner, C., Schumacher, M., Schmoor, C., Ohneberg, K., Ofstad, A. P., Salsali, A., George, J. T., et al. (2021) · ESC Heart Failure

Diabetes Treatment and ManagementHeart Failure Treatment and Management

Cited by 85

The Effect of Intensive Diabetes Treatment on Resting Heart Rate in Type 1 Diabetes

Paterson, A. D., Rutledge, B. N., Cleary, P. A., Lachin, J. M., Crow, R. S., & for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2007) · Diabetes Care

Diabetes Management and ResearchDiabetes Treatment and Management

Cited by 81

Causes of death in a contemporary cohort of patients with type 2 diabetes and atherosclerotic cardiovascular disease: insights from the tecos trial

Sharma, A., Green, J. B., Dunning, A., Lokhnygina, Y., Al-Khatib, S. M., Lopes, R. D., Buse, J. B., Lachin, J. M., Van de Werf, F., Armstrong, P. W., et al. (2017) · Diabetes Care

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 80

Increased risk of severe hypoglycemic events before and after cardiovascular outcomes in TECOS suggests an at-risk type 2 diabetes frail patient phenotype

Standl, E., Stevens, S. R., Armstrong, P. W., Buse, J. B., Chan, J. C. N., Green, J. B., Lachin, J. M., Scheen, A., Travert, F., Van de Werf, F., et al. (2018) · Diabetes Care

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 76

Lack of durable improvements in β-cell function following withdrawal of pharmacological interventions in adults with impaired glucose tolerance or recently diagnosed type 2 diabetes

The RISE Consortium, Ehrmann, D. A., Temple, K. A., Rue, A., Barengolts, E., Mokhlesi, B., Van Cauter, E., Sam, S., Miller, M. A., Kahn, S. E., et al. (2019) · Diabetes Care

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 73

The impact of physical activity on the prevention of type 2 diabetes: Evidence and lessons learned from the Diabetes Prevention Program, a long-standing clinical trial incorporating subjective and objective activity measures

Kriska, A. M., Rockette-Wagner, B., Edelstein, S. L., Bray, G. A., Delahanty, L. M., Hoskin, M. A., Horton, E. S., Venditti, E. M., Knowler, W. C., DPP Research Group, et al. (2021) · Diabetes Care

Physical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 70

Mediation of the effect of glycemia on the risk of CVD outcomes in type 1 diabetes: the DCCT/EDIC study

Bebu, I., Braffett, B. H., Orchard, T. J., Lorenzi, G. M., Lachin, J. M., & the DCCT/EDIC Research Group (2019) · Diabetes Care

Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 62