The role of cellular senescence in ageing and endocrine disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · see citing works

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J., & Toussaint, O. (2009) · Nature Protocols · doi:10.1038/nprot.2009.191 · Cited by 1,668 · see citing works

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · see citing works

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works

Ink4a/Arf expression is a biomarker of aging

Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454 · see citing works

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · see citing works

Rapamycin: one drug, many effects

Li, J., Kim, S. G., & Blenis, J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.001 · Cited by 1,287 · see citing works

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · see citing works

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255 · see citing works

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4385 · Cited by 1,182 · see citing works

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

Verstovšek, S., Kantarjian, H. M., Mesa, R. A., Pardanani, A. D., Cortes, J. E., Thomas, D. A., Estrov, Z. E., Fridman, J. S., Bradley, E. C., Erickson‐Viitanen, S., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002028 · Cited by 1,165 · see citing works

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3195 · Cited by 1,160 · see citing works

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., et al. (2016) · Aging Cell · doi:10.1111/acel.12445 · Cited by 1,148 · see citing works

Prevalence of pituitary adenomas: a community‐based, cross‐sectional study in Banbury (Oxfordshire, UK)

Fernández, A., Karavitaki, N., & Wass, J. A. H. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03667.x · Cited by 1,116 · see citing works

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works

Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction

Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044 · see citing works

Osteoporosis treatment: recent developments and ongoing challenges

Khosla, S., & Hofbauer, L. C. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30188-2 · Cited by 1,034 · see citing works

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works

Cellular senescence: a translational perspective

Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Unmasking Transcriptional Heterogeneity in Senescent Cells

Hernandez-Segura, A., de Jong, T. V., Melov, S., Guryev, V., Campisi, J., & Demaria, M. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.033 · Cited by 972 · see citing works

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

Hewitt, G., Jurk, D., Marques, F. D. M., Correia-Melo, C., Hardy, T., Gackowska, A., Anderson, R., Taschuk, M., Mann, J., & Passos, J. F. (2012) · Nature Communications · doi:10.1038/ncomms1708 · Cited by 908 · see citing works

A crucial role for adipose tissue p53 in the regulation of insulin resistance

Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works

Unmasking senescence: context-dependent effects of SASP in cancer

Faget, D. V., Ren, Q., & Stewart, S. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0156-2 · Cited by 863 · see citing works

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3225 · Cited by 788 · see citing works

mTOR inhibition improves immune function in the elderly

Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786 · see citing works

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., & Kirkland, J. L. (2017) · Aging · doi:10.18632/aging.101202 · Cited by 757 · see citing works

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738 · see citing works

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00314-z · Cited by 701 · see citing works

Rapamycin slows aging in mice

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 682 · see citing works

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works

Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Moiseeva, O., Deschênes‐Simard, X., St‐Germain, E., Igelmann, S., Huot, G., Cadar, A. E., Bourdeau, V., Pollak, M. N., & Ferbeyre, G. (2013) · Aging Cell · doi:10.1111/acel.12075 · Cited by 654 · see citing works

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604 · see citing works

Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response

Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works

Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

The dynamic nature of senescence in cancer

Lee, S., & Schmitt, C. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0249-2 · Cited by 588 · see citing works

Aggressive Pituitary Tumors

Chatzellis, E., Alexandraki, K., Androulakis, I. I., & Kaltsas, G. (2015) · Neuroendocrinology · doi:10.1159/000371806 · Cited by 573 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Identification of senescent cells in the bone microenvironment

Farr, J. N., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M. M., Drake, M. T., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2892 · Cited by 562 · see citing works

The Clinical potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., & Robbins, P. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14969 · Cited by 539 · see citing works

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.008 · Cited by 536 · see citing works

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532 · see citing works

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.092 · Cited by 530 · see citing works

Methods to Detect Biomarkers of Cellular Senescence

Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 516 · see citing works

Untitled work

(1995) · PubMed · Cited by 496 · see citing works

TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aaq1564 · Cited by 496 · see citing works

Indexed Pain Journals

(U.S.), N. L. O. M. (2008) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360280801989377 · Cited by 474 · see citing works

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G., & Bonner-Weir, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.006 · Cited by 469 · see citing works

Pathogenesis of pituitary tumors

Melmed, S. K. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.40 · Cited by 468 · see citing works

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201206006 · Cited by 439 · see citing works

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015) · Diabetes · doi:10.2337/db14-1820 · Cited by 423 · see citing works

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

McShea, A., Harris, P. L. R., Webster, K. R., Wahl, A. F., & Smith, M. A. (1997) · Europe PMC (PubMed Central) · Cited by 422 · see citing works

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works

Biomarkers of cellular senescence and skin aging

Wang, A. S., & Dreesen, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00247 · Cited by 404 · see citing works

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

Bannister, C. A., Holden, S. E., Jenkins‐Jones, S., Morgan, C. L., Halcox, J. P., Schernthaner, G., Mukherjee, J., & Currie, C. J. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12354 · Cited by 356 · see citing works

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw154 · Cited by 352 · see citing works

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Helman, A., Klochendler, A., Azazmeh, N., Gabai, Y., Horwitz, E., Anzi, S., Swisa, A., Condiotti, R., Granit, R. Z., Nevo, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4054 · Cited by 351 · see citing works

Cellular senescence: at the nexus between ageing and diabetes

Palmer, A. K., Gustafson, B., Kirkland, J. L., & Smith, U. (2019) · Diabetologia · doi:10.1007/s00125-019-4934-x · Cited by 337 · see citing works

Aged-senescent cells contribute to impaired heart regeneration

Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317 · see citing works

Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

Palmer, A. K., & Kirkland, J. L. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.013 · Cited by 313 · see citing works

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

Goldman, D. P., Cutler, D., Rowe, J. W., Michaud, P., Sullivan, J. H., Peneva, D., & Olshansky, S. J. (2013) · Health Affairs · doi:10.1377/hlthaff.2013.0052 · Cited by 312 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies

Tchkonia, T., & Kirkland, J. L. (2018) · JAMA · doi:10.1001/jama.2018.12440 · Cited by 302 · see citing works

Rapamycin Extends Life and Health in C57BL/6 Mice

Zhang, Y., Bokov, A. F., Gelfond, J., Soto, V., Ikeno, Y., Hubbard, G. B., Diaz, V., Sloane, L. B., Maslin, K., Treaster, S. B., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt056 · Cited by 276 · see citing works

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Zhu, Y., Armstrong, J. L., Tchkonia, T., & Kirkland, J. L. (2014) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000065 · Cited by 273 · see citing works

The number of p16INK4a positive cells in human skin reflects biological age

Waaijer, M. E. C., Parish, W. E., Strongitharm, B. H., van Heemst, D., Slagboom, P. E., de Craen, A. J. M., Sedivy, J. M., Westendorp, R. G. J., Gunn, D. A., & Maier, A. B. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00837.x · Cited by 264 · see citing works

Pathobiology of Pituitary Adenomas and Carcinomas

Scheithauer, B. W., Gaffey, T. A., Lloyd, R. V., Sebo, T. J., Kovács, K., Horváth, É., Kurtkaya-Yapcer, Ö., Young, W. F., Meyer, F. B., Kuroki, T., et al. (2006) · Neurosurgery · doi:10.1227/01.neu.0000223437.51435.6e · Cited by 263 · see citing works

Cellular senescence in bone

Farr, J. N., & Khosla, S. (2019) · Bone · doi:10.1016/j.bone.2019.01.015 · Cited by 263 · see citing works

Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity

St Sauver, J. L., Boyd, C. M., Grossardt, B. R., Bobo, W. V., Finney Rutten, L. J., Roger, V. L., Ebbert, J. O., Therneau, T. M., Yawn, B. P., & Rocca, W. A. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006413 · Cited by 257 · see citing works

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

Swanson, E. C., Manning, B., Zhang, H., & Lawrence, J. B. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201306073 · Cited by 251 · see citing works

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

Walaszczyk, A., Dookun, E., Redgrave, R., Tual‐Chalot, S., Victorelli, S., Spyridopoulos, I., Owens, A., Arthur, H. M., Passos, J. F., & Richardson, G. D. (2019) · Aging Cell · doi:10.1111/acel.12945 · Cited by 250 · see citing works

Prevalence of Multimorbidity in a Geographically Defined American Population

Rocca, W. A., Boyd, C. M., Grossardt, B. R., Bobo, W. V., Rutten, L. J. F., Roger, V. L., Ebbert, J. O., Therneau, T. M., Yawn, B. P., & Sauver, J. L. S. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.010 · Cited by 245 · see citing works

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Apelo, S. I. A., & Lamming, D. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw090 · Cited by 238 · see citing works

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S., & Campisi, J. (2017) · Aging Cell · doi:10.1111/acel.12632 · Cited by 234 · see citing works

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00818.x · Cited by 229 · see citing works

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

Waldera Lupa, D. M., Kalfalah, F., Safferling, K., Boukamp, P., Poschmann, G., Volpi, E., Götz-Rösch, C., Bernerd, F., Haag, L., Huebenthal, U., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.120 · Cited by 224 · see citing works

The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis

Papatheodoridi, A., Chrysavgis, L., Koutsilieris, M., & Chatzigeorgiou, A. (2019) · Hepatology · doi:10.1002/hep.30834 · Cited by 206 · see citing works

Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling

Majumder, S., Caccamo, A., Medina, D. X., Benavides, A. D., Javors, M. A., Kraig, E., Strong, R., Richardson, A. G., & Oddo, S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00791.x · Cited by 202 · see citing works

Old age causes de novo intracortical bone remodeling and porosity in mice

Piemontese, M., Almeida, M., Robling, A. G., Kim, H., Xiong, J., Thostenson, J. D., Weinstein, R. S., Manolagas, S. C., O’Brien, C. A., & Jilka, R. L. (2017) · JCI Insight · doi:10.1172/jci.insight.93771 · Cited by 198 · see citing works

Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors

Zaragosi, L.-E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., et al. (2010) · Diabetes · doi:10.2337/db10-0013 · Cited by 184 · see citing works

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J. E., Kiel, D. P., Rosen, C. J., Saag, K. G., & Shane, E. J. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3074 · Cited by 184 · see citing works

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

Gustafson, B., Nerstedt, A., & Smith, U. (2019) · Nature Communications · doi:10.1038/s41467-019-10688-x · Cited by 182 · see citing works

Age, anatomic site, and the replication and differentiation of adipocyte precursors

Kirkland, J. L., Hollenberg, C. H., & Gillon, W. S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.2.c206 · Cited by 180 · see citing works

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

Birch, J., Barnes, P. J., & Passos, J. F. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.005 · Cited by 173 · see citing works

Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

Patil, P. R., Dong, Q. D., Wang, D., Chang, J., Wiley, C. D., Demaria, M., Lee, J., Kang, J. D., Niedernhofer, L. J., Robbins, P. D., et al. (2019) · Aging Cell · doi:10.1111/acel.12927 · Cited by 169 · see citing works

Clinical strategies and animal models for developing senolytic agents

Kirkland, J. L., & Tchkonia, T. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.012 · Cited by 168 · see citing works

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L., & Schwartz, S. (2017) · Aging · doi:10.18632/aging.101328 · Cited by 165 · see citing works

Insulin‐like growth factor‐1 regulates the <scp>SIRT</scp> 1‐p53 pathway in cellular senescence

Tran, D., Bergholz, J., Zhang, H., He, H., Wang, Y., Zhang, Y., Li, Q., Kirkland, J. L., & Xiao, Z. (2014) · Aging Cell · doi:10.1111/acel.12219 · Cited by 161 · see citing works

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

Hannou, S. A., Wouters, K., Paumelle, R., & Staels, B. (2015) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2015.01.008 · Cited by 159 · see citing works

Cellular Senescence and the Biology of Aging, Disease, and Frailty

LeBrasseur, N. K., Tchkonia, T., & Kirkland, J. L. (2015) · Nestlé Nutrition Institute Workshop Series · doi:10.1159/000382054 · Cited by 147 · see citing works

Whole Chromosome Instability induces senescence and promotes SASP

Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Tsai, W. L., Santambrogio, L., Maslov, A. Y., Gadina, M., Campisi, J., Vijg, J., et al. (2016) · Scientific Reports · doi:10.1038/srep35218 · Cited by 146 · see citing works

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X.-Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L. J., et al. (2019) · Translational Research · doi:10.1016/j.trsl.2019.07.005 · Cited by 139 · see citing works

Hyperglycemia Accelerated Endothelial Progenitor Cell Senescence via the Activation of p38 Mitogen-Activated Protein Kinase

Kuki, S., Imanishi, T., Kobayashi, K., Matsuo, Y., Obana, M., & Akasaka, T. (2006) · Circulation Journal · doi:10.1253/circj.70.1076 · Cited by 137 · see citing works

Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Moncsek, A., Al‐Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., et al. (2018) · Hepatology · doi:10.1002/hep.29464 · Cited by 136 · see citing works

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Spong, A., Masternak, M. M., et al. (2014) · Aging · doi:10.18632/aging.100681 · Cited by 135 · see citing works

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

Khosla, S., Farr, J. N., & Kirkland, J. L. (2018) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2017-02694 · Cited by 130 · see citing works

Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein

Miao, D., Su, H., He, B., Jianjun, G., Xia, Q., Zhu, M., Gu, Z., Goltzman, D., & Karaplis, A. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805690105 · Cited by 129 · see citing works

Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B., & Nicklas, B. J. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx134 · Cited by 129 · see citing works

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

Vergoni, B., Cornejo, P.-J., Gilleron, J., Djedaini, M., Ceppo, F., Jacquel, A., Bouget, G., Ginet, C., Gonzalez, T., Maillet, J., et al. (2016) · Diabetes · doi:10.2337/db16-0014 · Cited by 119 · see citing works

p53 Functions in Adipose Tissue Metabolism and Homeostasis

Krstić, J., Reinisch, I., Schupp, M., Schulz, T. J., & Prokesch, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092622 · Cited by 106 · see citing works

Impact of the U.S. Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates After Hip Fracture

Kim, S. C., Kim, D. H., Mogun, H., Eddings, W., Polinski, J. M., Franklin, J. M., & Solomon, D. H. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2832 · Cited by 105 · see citing works

Cellular senescence and radiation-induced pulmonary fibrosis

He, Y., Thummuri, D., Zheng, G., Okunieff, P. G., Citrin, D. E., Vujašković, Ž., & Zhou, D. (2019) · Translational research · doi:10.1016/j.trsl.2019.03.006 · Cited by 104 · see citing works

Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?

Ashapkin, V. V., Kutueva, L. I., Kurchashova, S., & Kireev, I. I. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00455 · Cited by 95 · see citing works

Programmed cell senescence in skeleton during late puberty

Li, C., Chai, Y., Wang, L., Gao, B., Chen, H., Gao, P., Zhou, F.-Q., Luo, X., Crane, J. L., Yu, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01509-0 · Cited by 92 · see citing works

Cellular senescence: Implications for metabolic disease

Schafer, M. J., Miller, J. D., & LeBrasseur, N. K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.047 · Cited by 84 · see citing works

Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells

Parikh, P., Britt, R. D., Manlove, L. J., Wicher, S. A., Roesler, A. M., Ravix, J., Teske, J. J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., et al. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0176oc · Cited by 84 · see citing works

Resilience in Aging Mice

Kirkland, J. L., Stout, M. B., & Sierra, F. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw086 · Cited by 82 · see citing works

Translating the Science of Aging into Therapeutic Interventions

Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78 · see citing works

Telomere-driven replicative senescence is a stress response

von Zglinicki, T., Petrie, J., & Kirkwood, T. B. L. (2003) · Nature Biotechnology · doi:10.1038/nbt0303-229b · Cited by 76 · see citing works

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F. T., Milic, N. M., et al. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0263-5 · Cited by 76 · see citing works

Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism

Menon, R. (2019) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2019.62.4.199 · Cited by 75 · see citing works

Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction

Alam, P., Haile, B., Arif, M., Pandey, R., Rokvic, M., Nieman, M. L., Maliken, B. D., Paul, A., Wang, Y., Sadayappan, S., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012089 · Cited by 71 · see citing works

The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging

Farr, J. N., & Almeida, M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3564 · Cited by 69 · see citing works

Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Velarde, M. C., & Menon, R. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0018 · Cited by 64 · see citing works

Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study

Baylis, D., Ntani, G., Edwards, M. H., Syddall, H. E., Bartlett, D. B., Dennison, E. M., Martin-Ruiz, C. M., von Zglinicki, T., Kuh, D. J., Lord, J. M., et al. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9862-7 · Cited by 63 · see citing works

EFFECT OF LOW-DOSE RAPAMYCIN ON SENESCENCE MARKERS AND PHYSICAL FUNCTIONING IN OLDER ADULTS WITH CORONARY ARTERY DISEASE: RESULTS OF A PILOT STUDY

Singh, M., Jensen, M. D., Lerman, A., Kushwaha, S. S., Rihal, C., Gersh, B. J., Behfar, A., Tchkonia, T., Thomas, R. J., Lennon, R. J., et al. (2016) · The Journal of Frailty & Aging · doi:10.14283/jfa.2016.112 · Cited by 62 · see citing works

Polypharmacy Reduction Strategies

Levy, H. B. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.01.007 · Cited by 56 · see citing works

Cellular senescence in osteoarthritis and anti-aging strategies

Hou, A., Chen, P., Tang, H., Meng, H., Cheng, X., Wang, Y., Zhang, Y., & Peng, J. C. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.002 · Cited by 56 · see citing works

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N., & Austad, S. N. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw106 · Cited by 52 · see citing works

Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response?

Martyanov, V., Whitfield, M. L., & Varga, J. (2019) · Arthritis &amp; Rheumatology · doi:10.1002/art.40934 · Cited by 52 · see citing works

Low-dose dasatinib rescues cardiac function in Noonan syndrome

Yi, J.-S., Huang, Y., Kwaczala, A. T., Kuo, I. Y., Ehrlich, B. E., Campbell, S. G., Giordano, F. J., & Bennett, A. M. (2016) · JCI Insight · doi:10.1172/jci.insight.90220 · Cited by 48 · see citing works

Relationship Between In Vivo Age and In Vitro Aging: Assessment of 669 Cell Cultures Derived From Members of The Baltimore Longitudinal Study of Aging

Smith, J. R., Venable, S. F., Roberts, T. W., et al. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.6.b239 · Cited by 47 · see citing works

Genetic Regulation of the Growth Plate

Karimian, E., Chagin, A. S., & Savendahl, L. S. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00113 · Cited by 42 · see citing works

Roles of GSK3 in metabolic shift toward abnormal anabolism in cell senescence

Kim, Y., Seo, Y., Park, C., Yoon, S., & Yoon, G. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05617.x · Cited by 41 · see citing works

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O’Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00308.2018 · Cited by 40 · see citing works

Oncogene-induced senescence in pituitary adenomas and carcinomas

Alexandraki, K., Khan, M. M., Chahal, H., Dalantaeva, N. S., Trivellin, G., Berney, D. M., Caron, P. J., POPOVIC, V. M., Pfeifer, M., Jordan, S., et al. (2012) · HORMONES · doi:10.14310/horm.2002.1358 · Cited by 38 · see citing works

Odanacatib: Location and timing are everything

Khosla, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1541 · Cited by 37 · see citing works

Markers of cellular senescence are elevated in murine blastocysts cultured in vitro: molecular consequences of culture in atmospheric oxygen

Meuter, A., Rogmann, L.-M., Winterhoff, B. J., Tchkonia, T., Kirkland, J. L., & Morbeck, D. E. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0299-8 · Cited by 36 · see citing works

Deleted in B reast C ancer 1 regulates cellular senescence during obesity

Escande, C., Nin, V., Pirtskhalava, T., Chini, C. C. S., Barbosa, M. T., Mathison, A., Urrutia, R. A., Tchkonia, T., Kirkland, J. L., & Chini, E. N. (2014) · Aging Cell · doi:10.1111/acel.12235 · Cited by 32 · see citing works

Oncogene-Induced Senescence in Pituitary Adenomas—an Immunohistochemical Study

Manojlović-Gačić, E., Skender-Gazibara, M., POPOVIC, V. M., Soldatović, I., Boričić, N., Raičević, S., Pekić, S., Doknić, M., Miljić, D., Alafuzoff, I. I., et al. (2015) · Endocrine Pathology · doi:10.1007/s12022-015-9405-4 · Cited by 31 · see citing works

HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration

Sun, S., Cai, B., Li, Y., Su, W., Zhao, X.-Z., Gong, B., Li, Z., Zhang, X., Wu, Y., Chen, C., et al. (2019) · Aging · doi:10.18632/aging.102039 · Cited by 29 · see citing works

Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging

Mau, T., O’Brien, M., Ghosh, A. K., Miller, R. A., & Yung, R. L. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz177 · Cited by 27 · see citing works

The p27 Pathway Modulates the Regulation of Skeletal Growth and Osteoblastic Bone Formation by Parathyroid Hormone–Related Peptide

Zhu, M., Zhang, J., Zhan, D., Zhang, Y., Wang, R., Karaplis, A. C., Goltzman, D., & Miao, D. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2544 · Cited by 24 · see citing works

DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide

Zhang, Y., Chen, G., Gu, Z., Sun, H., Karaplis, A. C., Goltzman, D., & Miao, D. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23318 · Cited by 21 · see citing works

Growth hormone in adipose dysfunction and senescence

Stout, M. B., Tchkonia, T., & Kirkland, J. L. (2015) · Oncotarget · doi:10.18632/oncotarget.3997 · Cited by 11 · see citing works

Therapeutic Approaches to Aging—Reply

Tchkonia, T., & Kirkland, J. L. (2019) · JAMA · doi:10.1001/jama.2018.20554 · Cited by 4 · see citing works

Cellular senescence and senolytics: the path to the clinic

Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,105 · see citing works

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., Zhang, X., LeBrasseur, N. K., Pignolo, R. J., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32552-1 · Cited by 1,060 · see citing works

Strategies for targeting senescent cells in human disease

Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501 · see citing works

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499 · see citing works

Advances in pathogenesis and therapeutic strategies for osteoporosis

Song, S., Guo, Y., Yang, Y., & Fu, D. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2022.108168 · Cited by 476 · see citing works

Sex differences in biological aging with a focus on human studies

Hägg, S., & Jylhävä, J. (2021) · eLife · doi:10.7554/elife.63425 · Cited by 442 · see citing works

SenNet recommendations for detecting senescent cells in different tissues

Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00738-8 · Cited by 408 · see citing works

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Xu, Q., Fu, Q., Li, Z., Liu, H., Wang, Y., Lin, X., He, R., Zhang, X., Ju, Z., Campisi, J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00491-8 · Cited by 341 · see citing works

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Haston, S., Gonzalez-Gualda, E., Morsli, S., Ge, J., Reen, V., Calderwood, A., Moutsopoulos, I., Panousopoulos, L., Deletic, P., Carreno, G., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.05.004 · Cited by 251 · see citing works

Characterization of cellular senescence in aging skeletal muscle

Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00250-8 · Cited by 206 · see citing works

Senescent immune cells release grancalcin to promote skeletal aging

Li, C.-J., Xiao, Y., Sun, Y.-C., He, W.-Z., Liu, L., Huang, M., He, C., Huang, M., Chen, K.-X., Hou, J., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.009 · Cited by 190 · see citing works

Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence

Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185 · see citing works

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms

Tchkonia, T., Palmer, A. K., & Kirkland, J. L. (2021) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/clinem/dgaa728 · Cited by 129 · see citing works

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science · doi:10.1002/advs.202002611 · Cited by 129 · see citing works

Targeted clearance of <i>p21</i> ‐ but not <i>p16</i> ‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Chandra, A., Lagnado, A. B., Farr, J. N., Doolittle, M., Tchkonia, T., Kirkland, J. L., LeBrasseur, N. K., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13602 · Cited by 120 · see citing works

Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions

Tripathi, U., Misra, A., Tchkonia, T., & Kirkland, J. L. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111548 · Cited by 104 · see citing works

Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence

Zoico, E., Nori, N., Darra, E., Tebon, M., Rizzatti, V., Policastro, G., De Caro, A., Rossi, A. P., Fantin, F., & Zamboni, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02544-0 · Cited by 94 · see citing works

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging · doi:10.18632/aging.203560 · Cited by 88 · see citing works

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B., Zhu, Y., Weivoda, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162519 · Cited by 81 · see citing works

A Blueprint for Characterizing Senescence

Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N., Hodes, R. J., Wilder, E. L., & Anderson, J. M. (2020) · Cell · doi:10.1016/j.cell.2020.10.032 · Cited by 81 · see citing works

Modulation of fracture healing by the transient accumulation of senescent cells

Saul, D., Monroe, D. G., Rowsey, J. L., Kosinsky, R. L., Vos, S. J., Doolittle, M. L., Farr, J. N., & Khosla, S. (2021) · eLife · doi:10.7554/elife.69958 · Cited by 71 · see citing works

Advancements in therapeutic drugs targeting of senescence

Zhu, M., Meng, P., Ling, X., & Zhou, L. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320964125 · Cited by 68 · see citing works

Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency

Yang, R., Zhang, J., Li, J., Qin, R., Chen, J., Wang, R., Goltzman, D., & Miao, D. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.010 · Cited by 67 · see citing works

Exercise Counters the Age-Related Accumulation of Senescent Cells

Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000302 · Cited by 63 · see citing works

Osteocyte Cellular Senescence

Farr, J. N., Kaur, J., Doolittle, M. L., & Khosla, S. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00619-x · Cited by 60 · see citing works

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · Nature Communications · doi:10.1038/s41467-023-40393-9 · Cited by 57 · see citing works

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L., Saul, D., Kaur, J., Rowsey, J. L., Vos, S. J., Pavelko, K. D., Farr, J. N., Monroe, D. G., & Khosla, S. (2023) · doi:10.1101/2023.01.12.523760 · Cited by 57 · see citing works

How does adipose tissue contribute to inflammageing?

Zamboni, M., Nori, N., Brunelli, A., & Zoico, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2020.111162 · Cited by 55 · see citing works

Role of senescence in the chronic health consequences of COVID-19

Wissler Gerdes, E. O., Vanichkachorn, G., Verdoorn, B. P., Hanson, G. J., Joshi, A. Y., Murad, M. H., Rizza, S. A., Hurt, R. T., Tchkonia, T., & Kirkland, J. L. (2022) · Translational Research · doi:10.1016/j.trsl.2021.10.003 · Cited by 38 · see citing works

Senopathies-Diseases Associated with Cellular Senescence

Lushchak, O., Schosserer, M., & Grillari, J. (2023) · Biomolecules · doi:10.3390/biom13060966 · Cited by 35 · see citing works

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Samakkarnthai, P., Saul, D., Zhang, L., Aversa, Z., Doolittle, M. L., Sfeir, J. G., Kaur, J., Atkinson, E. J., Edwards, J. R., Russell, G. G., et al. (2023) · Aging · doi:10.18632/aging.204701 · Cited by 34 · see citing works

Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis

Kumar, S., Song, K., Wang, J., Baghel, M. S., Zeng, Y., Shen, K., Zheng, J., Crane, J., Demehri, S., Gao, P., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00924-z · Cited by 16 · see citing works

Adipose Tissue Plasticity in Response to Pathophysiological Cues: A Connecting Link between Obesity and Its Associated Comorbidities

De Fano, M., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · doi:10.20944/preprints202204.0011.v1 · Cited by 41 · see citing works

Initiation, Progression, and Genetic Manipulation of Leaf Senescence

Ali, A. A., Gao, X., & Guo, Y. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7672-0_2 · Cited by 27 · see citing works

Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes

Lee, R., Wang, C., Huang, L., et al. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.358.1117 · Cited by 195 · see citing works

Brassinosteroids and Senescence

Çağ, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6058-9_6 · Cited by 3 · see citing works

Gene expression during leaf senescence

Smart, C. M. (1994) · New Phytologist · doi:10.1111/j.1469-8137.1994.tb04243.x · Cited by 708 · see citing works

[Markers of cellular senescence].

Alster, O., & Korwek, Z. (2014) · PubMed · Cited by 5 · see citing works