Christ, Frauke

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Christ, F., Voet, A., Marchand, A., Nicolet, S., Desimmie, B. A., Marchand, D., Bardiot, D., Van der Veken, N. J., Van Remoortel, B., Strelkov, S. V., et al. (2010) · Nature Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 479

The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F., & Debyser, Z. (2005) · Journal of Biological Chemistry

HIV Research and TreatmentVirus-based gene therapy research

Cited by 208

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Desimmie, B. A., Schrijvers, R., Demeulemeester, J., Borrenberghs, D., Weydert, C., Thys, W., Vets, S., Van Remoortel, B., Hofkens, J., De Rijck, J., et al. (2013) · Retrovirology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 139

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

Vranckx, L. S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., et al. (2016) · EBioMedicine

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 113

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

Tesina, P., Čermáková, K., Hořejší, M., Procházková, K., Fábry, M., Sharma, S., Christ, F., Demeulemeester, J., Debyser, Z., Rijck, J. D., et al. (2015) · Nature Communications

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 74

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

Serrao, E., Xu, Z.-L., Debnath, B., Christ, F., Debyser, Z., Long, Y.-Q., & Neamati, N. (2013) · Bioorganic & Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 47

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Bruggemans, A., Vansant, G., Balakrishnan, M., Mitchell, M. L., Cai, R., Christ, F., & Debyser, Z. (2021) · Antimicrobial Agents and Chemotherapy

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 35

New scaffolds of natural origin as Integrase–LEDGF/p75 interaction inhibitors: Virtual screening and activity assays

De Luca, L., Morreale, F., Christ, F., Debyser, Z., Ferro, S., & Gitto, R. (2013) · European Journal of Medicinal Chemistry

Computational Drug Discovery MethodsHIV/AIDS drug development and treatment

Cited by 17