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Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges

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Protein–protein and protein–chromatin interactions of LEDGF/p75 as novel drug targets

Blokken, J., Rijck, J. D., Christ, F., & Debyser, Z. (2017) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2017.11.002 · Cited by 31 · see citing works

Multivalency of nucleosome recognition by LEDGF

Koutná, E., Lux, V., Kouba, T., Škerlová, J., Nováček, J., Srb, P., Hexnerova, R., Šváchová, H., Kukačka, Z., Novák, P., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad674 · Cited by 26 · see citing works

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

Perner, F., Gadrey, J. Y., Armstrong, S. A., & Kühn, M. W. M. (2025) · International Journal of Cancer · doi:10.1002/ijc.35332 · Cited by 26 · see citing works

Competition between PAF1 and MLL1/COMPASS confers the opposing function of LEDGF/p75 in HIV latency and proviral reactivation

Gao, R., Bao, J., Yan, H., Xie, L., Qin, W., Ning, H., Huang, S., Cheng, J., Zhi, R., Li, Z., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz8411 · Cited by 24 · see citing works

14‐3‐3 protein masks the nuclear localization sequence of caspase‐2

Smidova, A., Alblova, M., Kalábová, D., Pšenáková, K., Rosůlek, M., Heřman, P., Obšil, T., & Obšilová, V. (2018) · FEBS Journal · doi:10.1111/febs.14670 · Cited by 23 · see citing works

The elongation factor Spn1 is a multi-functional chromatin binding protein

Li, S., Almeida, A. R., Radebaugh, C. A., Zhang, L., Chen, X., Huang, L., Thurston, A. K., Kalashnikova, A. A., Hansen, J. C., Luger, K., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1305 · Cited by 21 · see citing works

Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy

Zhu, H., Wei, T., Cai, Y., & Jin, J. (2020) · Molecules · doi:10.3390/molecules25030578 · Cited by 22 · see citing works

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · eLife · doi:10.7554/elife.86721 · Cited by 21 · see citing works

Intrinsic protein disorder in histone lysine methylation

Lázár, T., Schád, É., Szabó, B., Horváth, T., Mészáros, A., Tompa, P., & Tantos, Á. (2016) · Biology Direct · doi:10.1186/s13062-016-0129-2 · Cited by 21 · see citing works

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells

Ortiz-Hernández, G. L., Sanchez-Hernández, E. S., Ochoa, P. T., Elix, C. C., Alkashgari, H. R., McMullen, J. R. W., Soto, U., Martinez, S. R., Osterman, C. J. D., Mähler, M., et al. (2021) · Cells · doi:10.3390/cells10102723 · Cited by 19 · see citing works

Bio-inspired writable multifunctional recycled paper with outer and inner uniform superhydrophobicity

Si, Y., & Guo, Z. (2016) · RSC Advances · doi:10.1039/c6ra04259g · Cited by 19 · see citing works

Y-box-binding protein 1 supports the early and late steps of HIV replication

Weydert, C., van Heertum, B., Dirix, L., Houwer, S. D., Wit, F. D., Mast, J., Husson, S. J., Busschots, K., König, R., Gijsbers, R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200080 · Cited by 18 · see citing works

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

Čermáková, K., Veverka, V., & Hodges, H. C. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220342 · Cited by 17 · see citing works

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection

Lampi, Y., Looveren, D. V., Vranckx, L. S., Thiry, I., Bornschein, S., Debyser, Z., & Gijsbers, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-38718-0 · Cited by 17 · see citing works

Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy

Wang, Z.-H., Li, D.-D., Chen, W.-L., You, Q.-D., & Guo, X.-K. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.11.045 · Cited by 16 · see citing works

H3K36me3 and PSIP1/LEDGF associate with several DNA repair proteins, suggesting their role in efficient DNA repair at actively transcribing loci

Jayakumar, S., Taylor, G. C. A., von Kriegsheim, A., & Pradeepa, M. M. (2021) · Wellcome Open Research · doi:10.12688/wellcomeopenres.11589.4 · Cited by 12 · see citing works

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia

Čermáková, K., Weydert, C., Christ, F., Rijck, J. D., & Debyser, Z. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.005 · Cited by 14 · see citing works

The Nuclear Dense Fine Speckled (DFS) Immunofluorescence Pattern: Not All Roads Lead to DFS70/LEDGFp75

Sanchez-Hernández, E. S., Ortiz-Hernández, G. L., Ochoa, P. T., Reeves, M., Bizzaro, N., Andrade, L. E. C., Mähler, M., & Casiano, C. A. (2023) · Diagnostics · doi:10.3390/diagnostics13020222 · Cited by 13 · see citing works

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

Canella, A., Belle, S. V., Brouns, T., Nigita, G., Carlon, M. S., Christ, F., & Debyser, Z. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00319-3 · Cited by 13 · see citing works

Virus–Host Interactions in Retrovirus Integration

Engelman, A. N., & Maertens, G. N. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00004-2 · Cited by 12 · see citing works

Glucocorticoid Receptor and β-Catenin Interact in Prostate Cancer Cells and Their Co-Inhibition Attenuates Tumorsphere Formation, Stemness, and Docetaxel Resistance

Martinez, S. R., Elix, C. C., Ochoa, P. T., Sanchez-Hernández, E. S., Alkashgari, H. R., Ortiz-Hernández, G. L., Zhang, L., & Casiano, C. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087130 · Cited by 12 · see citing works

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

Belle, S. V., Ashkar, S. E., Čermáková, K., Matthijssens, F., Goossens, S., Canella, A., Hodges, H. C., Christ, F., Rijck, J. D., Vlierberghe, P. V., et al. (2021) · Cells · doi:10.3390/cells10010192 · Cited by 12 · see citing works

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells

Sanchez-Hernández, E. S., Ochoa, P. T., Suzuki, T., Ortiz-Hernández, G. L., Unternaehrer, J., Alkashgari, H. R., Osterman, C. J. D., Martinez, S. R., Chen, Z., Kremsky, I., et al. (2023) · Cells · doi:10.3390/cells12162046 · Cited by 10 · see citing works

Rational fragment-based design of compounds targeting the PWWP domain of the HRP family

Vantieghem, T., Aslam, N. A., Osipov, E. M., Akele, M. Z., Belle, S. V., Beelen, S., Drexler, M., Paulovcakova, T., Lux, V., Fearon, D., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116960 · Cited by 10 · see citing works

HIV-1 Integrase Inhibition: Looking at Cofactor Interactions

Christ, F., & Debyser, Z. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.162 · Cited by 10 · see citing works

Molecular Mechanism of LEDGF/p75 Dimerization

Lux, V., Brouns, T., Čermáková, K., Srb, P., Fábry, M., Mádlíková, M., Hořejší, M., Kukačka, Z., Novák, P., Kugler, M., et al. (2020) · Structure · doi:10.1016/j.str.2020.08.012 · Cited by 10 · see citing works

Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair

Pradeepa, M. M., Taylor, G. C. A., & von Kriegsheim, A. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.11589.1 · Cited by 8 · see citing works

Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading

Dou, K., Liu, Y., Zhang, Y., Wang, C., Huang, Y., & Zhang, Z. Z. (2020) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2020.02.008 · Cited by 10 · see citing works

Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential

Akele, M. Z., Iervolino, M., Belle, S. V., Christ, F., & Debyser, Z. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189248 · Cited by 9 · see citing works

TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation

Saul, M. J., Groher, F., Hegewald, A. B., Müller-McNicoll, M., Marschalek, R., Suess, B., & Steinhilber, D. (2017) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2017.07.006 · Cited by 9 · see citing works

Decision-making value of nuclear dense fine speckled pattern in systemic autoimmune rheumatic disease: trick or treat?

Deng, C., Qu, X., Cheng, S., Zeng, X., Li, Y., & Fei, Y. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215587 · Cited by 9 · see citing works

Low Prevalence of Anti-DFS70 Antibodies in Children With ANA-Associated Autoimmune Disease

Freudenhammer, M., Salzer, U., Heselich, A., Hufnagel, M., & Janda, A. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.839928 · Cited by 8 · see citing works

The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevance

Cruvinel, W. D. M., Ferreira, G. G., de Souza, L. L., Neto, W. D. C. V., Gomes, C. M., Francescantônio, P. L. C., & Andrade, L. E. C. (2025) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2025-0286 · Cited by 7 · see citing works

The Emerging Roles of the Stress Epigenetic Reader LEDGF/p75 in Cancer Biology and Therapy Resistance: Mechanisms and Targeting Opportunities

Ortiz-Hernández, G. L., Sanchez-Hernández, E. S., Ochoa, P. T., & Casiano, C. A. (2024) · Cancers · doi:10.3390/cancers16233957 · Cited by 6 · see citing works

Structure and function of IWS1 in transcription elongation

Syau, D., Steinruecke, F., Roth, S., Schmid, E., Adelman, K., Walter, J. C., & Farnung, L. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag357 · Cited by 5 · see citing works

The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

Brouns, T., Lux, V., Belle, S. V., Christ, F., Veverka, V., & Debyser, Z. (2024) · Cells · doi:10.3390/cells13030227 · Cited by 5 · see citing works

LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates

Lesire, S., Lata, R., Hoogvliets, Y., Herrebosch, K., de Velde, P. V., Speleers, A., Christ, F., Belle, S. V., & Debyser, Z. (2024) · Structure · doi:10.1016/j.str.2024.10.016 · Cited by 5 · see citing works

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · eLife · doi:10.7554/elife.86721.4 · Cited by 5 · see citing works

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Zhang, Y., Zhou, Y., Zhang, Y., Lv, J., Shen, Y., Zhang, D., Liu, B., Zhao, W., Ju, J., Zhu, Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202416809 · Cited by 4 · see citing works

Epigenetic mechanisms of retroviral regulation: a comparative review

Shin, S. Y., Tahmida, M., Beliakova‐Bethell, N., & LaMere, S. A. (2026) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00659-6 · Cited by 3 · see citing works

The Prevalence and Clinical Relevance of the DFS Immunofluorescence Staining Pattern in a Large ANA-Positive Cohort

Deng, C., Wang, A., Hu, C., Zhang, W., Zeng, X., & Fei, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.829436 · Cited by 3 · see citing works

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferasesPreprint

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · eLife · doi:10.7554/elife.86721.1 · Cited by 2 · see citing works

Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain

Jin, Z., Meng, Z., Liu, Y., Li, C., Zhang, X., Yin, Y., Gao, G., Dou, K., & Huang, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-07895-2 · Cited by 1 · see citing works

A meta-analysis of multiple matched aCGH/expression cancer datasets reveals regulatory relationships and pathway enrichment of potential oncogenes

Newton, R., & Wernisch, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213221 · Cited by 1 · see citing works

LEDGF Interacts with the NID of MeCP2 and Modulates MeCP2 CondensatesPreprint

Lesire, S., Lata, R., Hoogvliets, Y., Herrebosch, K., de Velde, P. V., Speleers, A., Christ, F., Belle, S. V., & Debyser, Z. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.24.590897 · Cited by 1 · see citing works

The role of LEDGF in transcription is exploited by HIV-1 to position integrationPreprint

Pathak, R., Esnault, C., Radhakrishnan, R., Singh, P. K., Zhang, H., Dale, R., Anand, A., Bedwell, G. J., Engelman, A., Rabi, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.29.601340 · Cited by 1 · see citing works

"...the unique multimodal mode of action (of LEDGINs) and the lack of cross-resistance with any known class of ARVs make them excellent candidates for future cART, in particular for patients failing on current therapy."

Christ, F. (2015)

CD71 + erythroid cells exacerbate HIV-1 infection by reactive oxygen species and trans-infect HIV to CD4 + T cellsPreprint

Namdar, A., Dunsmore, G., Koleva, P. T., Shahbaz, S., Jovel, J., Houston, S. C., & Elahi, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/622712

dP75 safeguards oogenesis by preventing H3K9me2 spreadingPreprint

Dou, K., Liu, Y., Zhang, Y., Wang, C., Huang, Y., & Zhang, Z. Z. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/856021

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferasesPreprint

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.30.526367

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferasesPreprint

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · eLife · doi:10.7554/elife.86721.2

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferasesPreprint

Funabiki, H., Wassing, I. E., Jia, Q., Luo, J., & Carroll, T. D. (2023) · eLife · doi:10.7554/elife.86721.3

Mechanistic insights into the phosphorylation-regulated a disordered protein interaction module

Zang, Y., Ni, Y., Li, X., Yang, Z., Fu, Z., & Zhang, S. (2025) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2025.2460748

Absence of Ledgf in mouse brain affects the Kmt2a/b and polycomb balance, synaptic transmission and motor function

Debusschere, L., Bentea, E., Iglesias-Herrero, C., Peredo, N., Belle, S. V., der Veken, N. J. V., Janer, A. B., Plessers, D., Peelaerts, W., Hannes, W., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02216-4

Relationship between the distribution of LEDGF along genes and positions of HIV-1 DNA integration

Pathak, R., Esnault, C., Radhakrishnan, R., Singh, P. K., Zhang, H., Dale, R., Anand, A., Mitra, A., Bedwell, G. J., Engelman, A., et al. (2026) · mBio · doi:10.1128/mbio.00090-26 · Cited by 2 · see citing works

Activités multiples des inhibiteurs allostériques de l’interaction entre l’Intégrase du VIH-1 et son cofacteur LEDGF/p75

Bonnard, D. (2017) · doi:10.70675/c548c34cz3362z42dazb03cza37907b802c7

Protein‐Protein Interaction as an Efficient Target to Inhibit HIV‐1 Integrase

Zarghi, A., & Hajimahdi, Z. (2026) · Archiv der Pharmazie · doi:10.1002/ardp.70221

BindingDB Entry 50002146: Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.

BindingDB (2020) · UC San Diego · doi:10.7270/q2sq92zs

BindingDB Entry 50022853: Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.

BindingDB (2026) · UC San Diego · doi:10.7270/q2s75n55

Structural studies of LEDGF/p75 interactions

Těšina, P. (2016) · Digital Repository (National Repository of Grey Literature)

Preparation and characterization of human cellular cofactors of retroviral integration.

Čermáková, K. (2010) · Digital Repository (National Repository of Grey Literature)

Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75

Bartholomeeusen, K., Rijck, J. D., Busschots, K., Desender, L., Gijsbers, R., Emiliani, S., Bénarous, R., Debyser, Z., & Christ, F. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.06.090 · Cited by 87 · see citing works

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ

Bartholomeeusen, K., Christ, F., Hendrix, J., Rain, J., Emiliani, S., Bénarous, R., Debyser, Z., Gijsbers, R., & Rijck, J. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807781200 · Cited by 97 · see citing works

A conserved interaction motif found in all LEDGF/p75 binding proteins is mimicked by HIV integrase

Těšina, P., Čermáková, K., Rijck, J. D., Hořejší, M., Procházková, K., Fábry, M., Christ, F., Demeulemeester, J., Verveka, V., Řezáčová, P., et al. (2015)