Mechawar, Naguib

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers

Lopez, J. P., Fiori, L. M., Gross, J. A., Labonte, B., Yerko, V., Mechawar, N., & Turecki, G. (2014) · The International Journal of Neuropsychopharmacology

MicroRNA in disease regulationSuicide and Self-Harm Studies

Cited by 103

Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide

Nagy, C., Torres-Platas, S. G., Mechawar, N., & Turecki, G. (2016) · International Journal of Neuropsychopharmacology

Connexins and lens biologyTreatment of Major Depression

Cited by 98

The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study

Mechawar, N., & Descarries, L. (2001) · Neuroscience

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 91

Regulation of a Truncated Form of Tropomyosin-Related Kinase B (TrkB) by Hsa-miR-185* in Frontal Cortex of Suicide Completers

Maussion, G., Yang, J., Yerko, V., Barker, P., Mechawar, N., Ernst, C., & Turecki, G. (2012) · PLoS ONE

MicroRNA in disease regulationSuicide and Self-Harm Studies

Cited by 91

miR-323a regulates ERBB4 and is involved in depression

Fiori, L. M., Kos, A., Lin, R., Théroux, J.-F., Lopez, J. P., Kühne, C., Eggert, C., Holzapfel, M., Huettl, R.-E., Mechawar, N., et al. (2021) · Molecular Psychiatry

MicroRNA in disease regulationTreatment of Major Depression

Cited by 88

Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

Xiong, W., Cao, X., Zeng, Y., Qin, X., Zhu, M., Ren, J., Wu, Z., Huang, Q., Zhang, Y., Wang, M., et al. (2019) · The Journal of Neuroscience

Treatment of Major DepressionEicosanoids and Hypertension Pharmacology

Cited by 83

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications

Tryptophan and brain disordersTreatment of Major Depression

Cited by 82

Effects of Postmortem Interval on Biomolecule Integrity in the Brain

Nagy, C., Maheu, M., Lopez, J. P., Vaillancourt, K., Cruceanu, C., Gross, J. A., Arnovitz, M., Mechawar, N., & Turecki, G. (2015) · Journal of Neuropathology & Experimental Neurology

Molecular Biology Techniques and ApplicationsEpigenetics and DNA Methylation

Cited by 79

Hippocampal GABAergic Neurons are Susceptible to Amyloid-β Toxicity in vitro and are Decreased in Number in the Alzheimer's Disease TgCRND8 Mouse Model

Krantic, S., Isorce, N., Mechawar, N., Davoli, M. A., Vignault, E., Albuquerque, M., Chabot, J.-G., Moyse, E., Chauvin, J.-P., Aubert, I., et al. (2012) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 78

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Albuquerque, M. S., Mahar, I., Davoli, M. A., Chabot, J.-G., Mechawar, N., Quirion, R., & Krantic, S. (2015) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 71

Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer’s Disease

Mahar, I., Albuquerque, M. S., Mondragon-Rodriguez, S., Cavanagh, C., Davoli, M. A., Chabot, J.-G., Williams, S., Mechawar, N., Quirion, R., & Krantic, S. (2017) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 63

Excitatory inputs determine phase-locking strength and spike-timing of CA1 stratum oriens/alveus parvalbumin and somatostatin interneurons during intrinsically generated hippocampal theta rhythm

Huh, C. Y. L., Amilhon, B., Ferguson, K. A., Manseau, F., Torres-Platas, S. G., Peach, J. P., Scodras, S., Mechawar, N., Skinner, F. K., & Williams, S. (2016) · The Journal of Neuroscience

Neural dynamics and brain functionNeuroscience and Neuropharmacology Research

Cited by 57

Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications

Maitra, M., Nagy, C., Chawla, A., Wang, Y. C., Nascimento, C., Suderman, M., Théroux, J.-F., Mechawar, N., Ragoussis, J., & Turecki, G. (2021) · Nature Protocols

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 42