Hippocampal GABAergic Neurons are Susceptible to Amyloid-β Toxicity in vitro and are Decreased in Number in the Alzheimer's Disease TgCRND8 Mouse Model
Abstract
The relevance of γ-amino-butyric acid (GABA)-ergic dysfunctions in the pathology of Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized the toxicity of amyloid-β (Aβ) on hippocampal GABAergic neurons both in vivo and in vitro. In the TgCRND8 mouse model of AD, we found a significant decrease in the number of hippocampal neurons immunoreactive for glutamate decarboxylase 67 (GAD67), the enzyme synthesizing GABA. This decrease, which was specific for hippocampal CA1-3 fields, was observed at 6 months of age, long after the overproduction of soluble Aβ42 (between 2 and 4 months) and accumulation of insoluble Aβ into amyloid plaques (between 4 and 6 months). In vitro, neurotoxicity was observed in primary hippocampal cultures 72 h following the addition of Aβ42 solutions containing a mixture of soluble oligomers. Taken together, our results suggest that when cultured and exposed to Aβ in vitro, GABAergic neurons are susceptible to Aβ42 neurotoxicity. However, in TgCRND8 mice, the number of GABAergic neurons is not altered up to 6 months, in spite of the massive Aβ load. Combined with the previously reported increased sensitivity to seizures observed in younger (1.5-2 month-old) TgCRND8 mice, it is likely that Aβ toxicity leads to GABAergic neuron dysfunction prior to their losses at a later stage.
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The GABAergic system appears to be affected by amyloid toxicity already in early life of transgenic animals of cerebral amyloidosis.
“For example the GABAergic system, being a target of several anesthetics including isoflurane (Kotani and Akaike, 2013), appears to be affected by amyloid toxicity already in early life of transgenic animals of cerebral amyloidosis (Krantic et al., 2012).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Krantic et al., 2012
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- Authors
- Krantic, S., Isorce, N., Mechawar, N., Davoli, M. A., Vignault, E., Albuquerque, M., Chabot, J.-G., Moyse, E., Chauvin, J.-P., Aubert, I., McLaurin, J., & Quirion, R.
- Affiliations
- Inserm (FR)
- Douglas Mental Health University Institute (CA)
- Centre National de la Recherche Scientifique (FR)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Corresponding author
- Krantic, Slavica
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2012-03-20
- Volume
- 29
- Issue
- 2
- Pages
- 293-308
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1516257393
- Cited by
- 78
- References
- 47
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 2
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Adobe Systems
- University of Toronto
- Canadian Institutes of Health Research (8580_4)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid-beta
- MeSH terms
- Age Factors, Alzheimer Disease, Animals, Cells, Cultured, Disease Models, Animal, Embryo, Mammalian, Enzyme-Linked Immunosorbent Assay, Glutamate Decarboxylase, Hippocampus, Humans, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neurons, Peptide Fragments, Phosphopyruvate Hydratase, Time Factors, Amyloid beta-Peptides, Cell Death, Rats, Wistar, Vesicular Glutamate Transport Protein 1, Mice, Rats, Presenilin-1, GABAergic Neurons, In Vitro Techniques
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