Mechawar, Naguib

Sex-specific transcriptional signatures in human depression

Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine

Treatment of Major DepressionStress Responses and Cortisol

Cited by 748

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 694

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 545

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Nagy, C., Maitra, M., Tanti, A., Suderman, M., Théroux, J.-F., Davoli, M. A., Perlman, K., Yerko, V., Wang, Y. C., Tripathy, S. J., et al. (2020) · Nature Neuroscience

Treatment of Major DepressionSingle-cell and spatial transcriptomics

Cited by 532

Single-nucleus RNA sequencing shows convergent evidence from different cell types for altered synaptic plasticity in major depressive disorder

Nagy, C., Maitra, M., Tanti, A., Suderman, M., Théroux, J.-F., Mechawar, N., Ragoussis, J., & Turecki, G. (2018) · Nature Neuroscience

Treatment of Major DepressionSingle-cell and spatial transcriptomics

Cited by 523

Genome-wide epigenetic regulation by early-life trauma

Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., et al. (2012) · Archives of General Psychiatry

Epigenetics and DNA MethylationChild Abuse and Trauma

Cited by 488

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 388

Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesStress Responses and Cortisol

Cited by 361

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

Trépanier, M. O., Hopperton, K. E., Mizrahi, R., Mechawar, N., & Bazinet, R. P. (2016) · Molecular Psychiatry

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 360

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse

Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry

Stress Responses and CortisolSuicide and Self-Harm Studies

Cited by 345

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment

Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine

Treatment of Major DepressionMicroRNA in disease regulation

Cited by 308

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry

Epigenetics and DNA MethylationTreatment of Major Depression

Cited by 301

The neurodevelopmental origins of suicidal behavior

Turecki, G., Ernst, C., Jollant, F., Labonté, B., & Mechawar, N. (2012) · Trends in Neurosciences

Suicide and Self-Harm StudiesStress Responses and Cortisol

Cited by 299

Genome-Wide Methylation Changes in the Brains of Suicide Completers

Labonté, B., Suderman, M., Maussion, G., Lopez, J. P., Navarro-Sánchez, L., Yerko, V., Mechawar, N., Szyf, M., Meaney, M. J., & Turecki, G. (2013) · American Journal of Psychiatry

Epigenetics and DNA MethylationSuicide and Self-Harm Studies

Cited by 212

Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence

Lutz, P.-E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J. J., Zhou, Y., Chen, G. G., Wakid, M., Shaw, M., Almeida, D., et al. (2017) · American Journal of Psychiatry

Child Abuse and TraumaEpigenetics and DNA Methylation

Cited by 203

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications

Treatment of Major DepressionMicroRNA in disease regulation

Cited by 201

Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

Isingrini, E., Perret, L., Rainer, Q., Amilhon, B., Guma, E., Tanti, A., Martin, G., Robinson, J., Moquin, L., Marti, F., et al. (2016) · Nature Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 177

Neuropathology of mood disorders: Do we see the stigmata of inflammation?

Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 165

Neuropathology of suicide: Recent findings and future directions

Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry

Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 158

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia

Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L. C., Bray, N. J., et al. (2014) · Genome biology

Epigenetics and DNA MethylationSchizophrenia research and treatment

Cited by 157

Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides

Torres-Platas, S. G., Nagy, C., Wakid, M., Turecki, G., & Mechawar, N. (2016) · Molecular Psychiatry

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 148

Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness

Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits

Neuropeptides and Animal PhysiologyStress Responses and Cortisol

Cited by 139

High resolution dissection of reactive glial nets in Alzheimer’s disease

Bouvier, D. S., Jones, E. V., Quesseveur, G., Davoli, M. A., A. Ferreira, T., Quirion, R., Mechawar, N., & Murai, K. K. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 111

Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb

Mechawar, N., Saghatelyan, A., Grailhe, R., Scoriels, L., Gheusi, G., Gabellec, M.-M., Lledo, P.-M., & Changeux, J.-P. (2004) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsNicotinic Acetylcholine Receptors Study

Cited by 104