Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life
Open accessAbstract
Background Viral respiratory tract infections are the leading cause of acute illness during infancy and are closely linked to chronic inflammatory airway diseases later in life. However, the determinants of susceptibility to acute respiratory tract infections still need to be defined.Objective We investigated whether the individual variation in antiviral response at birth determines the risk for acute respiratory tract illness in the first year of life.Methods We studied 82 children who were enrolled in a birth cohort study of inner-city children with at least 1 parent with allergy or asthma. We cultured cord blood monocytes and assessed IFNG and CCL5 mRNA production at 24 hours after inoculation with respiratory syncytial virus. We also monitored the frequency of acute respiratory tract illness at 3-month intervals and analyzed nasal lavage samples for respiratory tract viruses at the time of illness during the first year.Results Respiratory tract infection was reported for 88% of subjects, and respiratory tract viruses were recovered in 74% of symptomatic children. We observed a wide range of antiviral responses in cord blood monocytes across the population. Furthermore, a decrease in production of IFNG (but not CCL5) mRNA in response to respiratory syncytial virus infection of monocytes was associated with a significant increase in the frequency of upper respiratory tract infections (r = -0.42, P < .001) and the prevalence of ear and sinus infections, pneumonias, and respiratory-related hospitalizations.Conclusion Individual variations in the innate immune response to respiratory tract viruses are detectable even at birth, and these differences predict the susceptibility to acute respiratory tract illness during the first year of life.
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Decreased monocyte interferon production at birth is correlated with increased risk of early life infection.
“Sumino and colleagues 62 correlated decreased monocyte interferon production at birth with increased risk of early life infection.”
From Impact of Tobacco Smoke and Nicotine Exposure on Lung Development (2016) · cites this paper as [62]
The Discussion reports that lower RSV-induced IFNG mRNA in cord-blood monocytes at birth was associated with more respiratory tract illness during the first year of life in infants at high risk for asthma and allergic disease. The claim broadens this to early-life infection generally; the Discussion says the response was not linked to some other types of infection. The measured response was IFNG mRNA, rather than interferon protein production. (LLM, conf=0.88)
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- Authors
- Sumino, K., Tucker, J., Shahab, M., Jaffee, K. F., Visness, C. M., Gern, J. E., Bloomberg, G. R., & Holtzman, M. J.
- Affiliations
- Washington University in St. Louis (US)
- Rho (United States) (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Holtzman, Michael J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 129
- Issue
- 5
- Pages
- 1267-1273.e1
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC3340511
- OpenAlex
- W1993987254
- Cited by
- 35
- References
- 38
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 4
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- AstraZeneca
- GlaxoSmithKline
- F. Hoffmann-La Roche
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases (U19AI070489)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- interferon-gamma, monocytes, umbilical cord blood, antiviral innate immunity, respiratory syncytial virus, RANTES, upper respiratory tract infection, viral susceptibility, nasal irrigation, inner-city children
- MeSH terms
- Adolescent, Adult, Cells, Cultured, Child, Female, Fetal Blood, Follow-Up Studies, Humans, Hypersensitivity, Infant, Infant, Newborn, Interferon-gamma, Male, Monocytes, Mothers, Pregnancy, Prognosis, Respiratory Syncytial Viruses, Respiratory Tract Infections, Risk, Cohort Studies, Respiratory Syncytial Virus Infections, Chemokine CCL5, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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