Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface
Open accessAbstract
The choroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop imaging tools to interrogate these functions in adult lateral ventricle ChP in whole-mount explants and in awake mice. By imaging epithelial cells in intact ChP explants, we observed calcium activity and secretory events that increased in frequency following delivery of serotonergic agonists. Using chronic two-photon imaging in awake mice, we observed spontaneous subcellular calcium events as well as strong agonist-evoked calcium activation and cytoplasmic secretion into CSF. Three-dimensional imaging of motility and mobility of multiple types of ChP immune cells at baseline and following immune challenge or focal injury revealed a range of surveillance and defensive behaviors. Together, these tools should help illuminate the diverse functions of this understudied body-brain interface.
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Macrophages were the most prevalent and were associated with blood vessels across all ages.
“Macrophages were the most prevalent and were associated with blood vessels across all ages (Figure S5G; Shipley et al., 2020).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Shipley et al., 2020
In adult and aged LV ChP, IHC showed that arteries and veins were regularly segmented across the tissue and connected by an expanded capillary-like network.
“In adult and aged LV ChP, IHC showed that arteries and veins were regularly segmented across the tissue (Figure 6E,F; Shipley et al., 2020) and connected by an expanded capillary-like network (Figure S6D) similar to human tissue (Hudson, 1960).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Shipley et al., 2020
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A cellular and spatial map of the choroid plexus across brain ventricles and agesPreprint
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A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Self-citationInflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation
Cui, J., Shipley, F. B., Shannon, M. L., Alturkistani, O., Dani, N., Webb, M. D., Sugden, A. U., Andermann, M. L., & Lehtinen, M. K. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.020 · Cited by 128 · see citing works
Self-citation
- Authors
- Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., Kishkovich, T., Jang, E., Klein, E. M., Goldey, G. J., He, K., Zhang, Y., Holtzman, M. J., Kirchhausen, T., Wyart, C., Moore, C. I., Andermann, M. L., & Lehtinen, M. K.
- Affiliations
- Boston Children's Hospital (US)
- Brown University (US)
- Beth Israel Deaconess Medical Center (US)
- Washington University in St. Louis (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Andermann, Mark L.
- Lehtinen, Maria K.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 108
- Issue
- 4
- Pages
- 623-639.e10
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7847245
- OpenAlex
- W3087583428
- Cited by
- 118
- References
- 86
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 30 · 2023: 20 · 2022: 17 · 2021: 14 · 2020: 2
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- McKnight Foundation
- Pew Charitable Trusts
- Dana Foundation
- National Science Foundation
- Richard and Susan Smith Family Foundation
- Klarman Family Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- choroid plexus, choroid plexus epithelium, cerebrospinal fluid production, calcium dynamics, serotonergic agonists, immune surveillance, blood-brain barrier, lateral ventricle, two-photon imaging
- MeSH terms
- Animals, Calcium, Cerebrospinal Fluid, Choroid Plexus, Epithelium, Serotonin Receptor Agonists, Mice, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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